Use of phosphatidylcholine liposomes for correction of mitochondrial phospholipid composition in the medulla oblongata and frontal lobes in hemorrhagic shock

1997 ◽  
Vol 123 (4) ◽  
pp. 322-325 ◽  
Author(s):  
G. F. Leskova ◽  
V. I. Udovichenko
Keyword(s):  
Hemorrhagic Shock ◽  
Medulla Oblongata ◽  
Phospholipid Composition ◽  
Frontal Lobes ◽  
Phosphatidylcholine Liposomes

scholarly journals Effect of liposomal phospholipid composition on cholesterol transfer between microsomal and liposomal vesicles

1986 ◽  
Vol 238 (3) ◽  
pp. 647-652 ◽  
Author(s):  
C Bhuvaneswaran ◽  
K A Mitropoulos
Keyword(s):  
Activation Energy ◽  
Enzyme Activity ◽  
Control System ◽  
Phospholipid Composition ◽  
Acyltransferase Activity ◽  
Phosphatidylcholine Liposomes ◽  
First Order ◽  
First Order Kinetics ◽  
Phospholipid Liposomes

Preincubation of rat liver microsomal vesicles at 37 degrees C in the presence of [3H]cholesterol/phospholipid liposomes results in a net transfer of cholesterol from liposomes to microsomal vesicles. This transfer follows first-order kinetics. For similar concentrations of the donor vesicles, rates of transfer are about 6-8 times lower with cholesterol/sphingomyelin liposomes compared with cholesterol/phosphatidylcholine liposomes. Also, transfer of cholesterol from cholesterol/sphingomyelin liposomes to microsomal vesicles reveals a larger activation energy than for the process from cholesterol/phosphatidylcholine liposomes. There is a significant correlation between the amount of liposomal cholesterol transferred to microsomal vesicles during preincubation and the increase found with acyl-CoA:cholesterol acyltransferase activity in these microsomes over their corresponding controls. If, however, liposomes made solely of phospholipids are substituted for the cholesterol/phospholipid liposomes in the preincubation system containing microsomal vesicles, then the acyl-CoA:cholesterol acyltransferase activity is decreased compared with the corresponding control system. Both sphingomyelin and phosphatidylcholine liposomes are equally effective in decreasing the enzyme activity. These results offer direct kinetic evidence for the positive correlation between cholesterol and sphingomyelin found in vivo in biological membranes.

scholarly journals Phospholipids of Synaptic Membranes in the Pathogenesis of Encephalopathy During Hemorrhagic Shock (Review)

2019 ◽  
Vol 15 (2) ◽  
pp. 99-114
Author(s):  
G. F. Leskova
Keyword(s):  
Blood Loss ◽  
Hemorrhagic Shock ◽  
Functional Activity ◽  
Brain Function ◽  
Structural Damage ◽  
Phospholipid Composition ◽  
Phospholipid Metabolism ◽  
Brain Cell ◽  
Synaptic Membranes ◽  
Massive Blood Loss

Correction of brain cell damages caused by massive blood loss is one of the urgent problems of hemorrhagic shock, which ensures the need in clarification of mechanisms of such damages with the prospect of developing strategies to restore the functional activity of neurons. Analysis of the data presented in the review suggests that the dysregulation of phospholipid metabolism underlies both structural damage of synaptic membranes and their functions, including receptor signaling, the disturbances of which lead to encephalopathy in hemorrhagic shock. Correction of synaptic membranes phospholipid composition seems to possess a potential for increasing the effectiveness of treatment of shock-induced brain function disorders.

Protective effect of phosphatidylcholine liposomes in cats with hemorrhagic shock

1995 ◽  
Vol 119 (5) ◽  
pp. 463-467 ◽  
Author(s):  
G. N. Kryzhanovskii ◽  
G. F. Leskova ◽  
V. I. Udovichenko ◽  
O. S. Kulikova
Keyword(s):  
Protective Effect ◽  
Hemorrhagic Shock ◽  
Phosphatidylcholine Liposomes
Sign in / Sign up

Export Citation Format

Share Document