Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia

2000 ◽  
Vol 130 (8) ◽  
pp. 756-758 ◽  
Author(s):  
I. I. Zamorskii ◽  
V. P. Pishak
Keyword(s):  
Lipid Peroxidation ◽  
Cyclic Nucleotide ◽  
Acute Hypoxia ◽  
Nucleotide Content

Changes in the cyclic nucleotide content in wound tissues during healing

1979 ◽  
Vol 87 (6) ◽  
pp. 625-627 ◽  
Author(s):  
I. M. Nosova ◽  
M. A. Zaidenberg ◽  
V. N. Petrosova ◽  
R. D. Seifulla ◽  
A. A. Karelin
Keyword(s):  
Cyclic Nucleotide ◽  
Nucleotide Content

Influence of Anoxia and Dinitrophenol on the Phosphorylase a Activity and the Cyclic Nucleotide Content of Smooth Muscle

2009 ◽  
Vol 52 (5) ◽  
pp. 328-334 ◽  
Author(s):  
H. Arnqvist ◽  
H. Groth ◽  
L. Lundholm ◽  
G. Pettersson ◽  
G. Wingren
Keyword(s):  
Smooth Muscle ◽  
Cyclic Nucleotide ◽  
Nucleotide Content

scholarly journals Influence of very low dietary intake of marine oil on some fuctional aspects of immune cells in healthy elderly people

2003 ◽  
Vol 89 (4) ◽  
pp. 523-531 ◽  
Author(s):  
Shaliha Bechoua ◽  
Madeleine Dubois ◽  
Evelyne Véricel ◽  
Paul Chapuy ◽  
Michel Lagarde ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Placebo Group ◽  
Elderly People ◽  
Cyclic Nucleotide ◽  
Elderly Subjects ◽  
Low Doses ◽  
Marine Oil ◽  
Healthy Elderly ◽  
Healthy Elderly People

Ageing is a multifactorial process involving decreased antioxidant defences and immune functions. n-3 Polyunsaturated fatty acids have been associated with human health benefits, especially against inflammatory and autoimmune diseases. However, their immunomodulatory effects were usually observed with high dosages (>2 g/d) known to increase lipid peroxidation. In contrast, very low doses, that may prevent lipid peroxidation, might affect the immune system differently. To study the latter hypothesis further, we investigated whether the supplementation of healthy elderly people with very low doses of marine oil (MO), a docosahexaenoate (DHA)- and eicosapentaenoate (EPA)-rich triacylglycerol, was able to affect lymphocyte proliferation and biochemical markers known to be altered with age. In a randomized, double-blind design, twenty healthy elderly subjects were assigned to a placebo group (600 mg sunflower oil/d) or to a group consuming 600 mg MO/d providing 150 mg DHA + 30 mg (EPA) for 6 weeks. At day 42, the proliferative responses of lymphocytes to several mitogens were significantly (P<0·01) decreased in the MO group compared with control values. This was accompanied by a slight lowering of their cytosolic cyclic nucleotide phosphodiesterase (PDE) activity, a marked and significant (P<0·05) increase of their particulate PDE activity (+56–57 %) and a slight but significant (P<0·05) increase in cyclic nucleotide intracellular levels. At the same time, the glutathione peroxidase activity was markedly and significantly (P<0·01) depressed in the MO group. None of these modifications could be seen in the placebo group. Collectively, these results demonstrate that even very low doses of n-3 fatty acids are sufficient to affect the immune responses of elderly subjects.

Epinephrine-induced changes in the cyclic nucleotide content of fish melanoma cells

1982 ◽  
Vol 47 (1) ◽  
pp. 88-93 ◽  
Author(s):  
S. Negishi ◽  
M. Masada ◽  
Y. Wakamatsu ◽  
T. Ohoka ◽  
M. Obika
Keyword(s):  
Cyclic Nucleotide ◽  
Melanoma Cells ◽  
Nucleotide Content ◽  
Induced Changes
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