scholarly journals An open multicenter study to compare the efficacy of intraperitoneal insemination and intrauterine insemination following multiple follicular development as treatment for unexplained infertility

1997 ◽  
Vol 14 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Silvia Ajossa ◽  
Gian Benedetto Melis ◽  
Antonio Cianci ◽  
Maria Elisabetta Coccia ◽  
Anna Maria Fulghesu ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Intrauterine Insemination ◽  
Follicular Development ◽  
Unexplained Infertility ◽  
Multiple Follicular Development

Induction of multiple follicular development and superovulation in the olive baboon, Papio anubis

1991 ◽  
Vol 20 (6) ◽  
pp. 308-314
Author(s):  
Thomas J. McCarthy ◽  
Jeffrey D. Fortman ◽  
Melinda L. Boice ◽  
Asgerally T. Fazleabas ◽  
Harold G. Verhage
Keyword(s):  
Follicular Development ◽  
Papio Anubis ◽  
Olive Baboon ◽  
Multiple Follicular Development

scholarly journals Evaluation of Endometrial Urocortin Secretion for Prediction of Pregnancy after Intrauterine Insemination

2008 ◽  
Vol 54 (2) ◽  
pp. 350-355 ◽  
Author(s):  
Pasquale Florio ◽  
Luca Bruni ◽  
Carmen De Falco ◽  
Gilda Filardi ◽  
Michela Torricelli ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Pregnancy Rate ◽  
Endometrial Thickness ◽  
Intrauterine Insemination ◽  
Biological Effects ◽  
Unexplained Infertility ◽  
Successful Pregnancy ◽  
Ultrasound Evaluation ◽  
Study Population ◽  
Blastocyst Implantation

Abstract Background: Urocortin is a neuropeptide produced by the human endometrium and has biological effects putatively important for promoting blastocyst implantation. We measured urocortin concentrations in samples of endometrial wash fluid collected from women with unexplained infertility who underwent intrauterine insemination (IUI). Methods: Patients 28–42 years of age (n = 71) were consecutively enrolled after a complete clinical evaluation. Endometrial wash fluid was retrieved before IUI, at the time of ultrasound evaluation of endometrial thickness. Urocortin concentrations were assayed with a specific ELISA. Results: After IUI, 28 patients (39%) became pregnant. Urocortin concentrations were significantly higher in women who became pregnant than in those who did not (0.38 μg/L vs 0.13 μg/L, P <0.0001). At a cutoff of 0.321 μg/L, urocortin results were positive in 61% [95% confidence interval (CI), 41%–78%] of women who had successful implantation and negative in 98% (95% CI, 88%–99.6%) of those who did not. The pregnancy rate for women with urocortin concentrations >0.32 μg/L was 94%, which differed significantly (P <0.05) from the overall pregnancy rate of 39% in the study population. Conclusions: Urocortin is measurable in endometrial wash fluid, and its concentrations before IUI are higher in women who subsequently achieve pregnancy. These data suggest that the probability of having a successful pregnancy-producing IUI may be better estimated by measuring urocortin in endometrial wash fluid.

scholarly journals Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility

2020 ◽  
Vol 25 (3) ◽  
pp. 427-433
Author(s):  
Süleyman Cemil Oğlak ◽  
Mehmet Nafi Sakar ◽  
Serhat Ege ◽  
Serap Mutlu Özçelik Otçu ◽  
Mehmet Obut ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Unexplained Infertility

A Randomized Clinical Trial to Evaluate Optimal Treatment for Unexplained Infertility

2021 ◽  
pp. 246-250
Author(s):  
Stephanie Rothenberg ◽  
Joseph Sanfilippo
Keyword(s):  
Ovulation Induction ◽  
Treatment Approach ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Additional Benefit ◽  
Multiple Gestation ◽  
Time To Pregnancy ◽  
Vitro Fertilization

The treatment of unexplained infertility has traditionally been comprised of a stepwise treatment approach, first with ovulation induction combined with intrauterine insemination (IUI) and then with in vitro fertilization (IVF). Ovulation induction is first attempted with clomiphene citrate, and, if unsuccessful, injectable gonadotropins are used. The value of ovulation induction with injectable gonadotropins in couples with unexplained infertility has been questioned, however, given the high risk of multiple gestation and the increasing efficacy of IVF. To address this, the FASTT trial randomized couples with unexplained infertility to a treatment arm that either included or omitted gonadotropin/IUI. They found that an accelerated treatment approach that involved 3 cycles of clomiphene citrate/IUI and then progressed immediately to IVF resulted in a decreased time to pregnancy compared to the group who underwent gonadotropin/IUI for 3 cycles, as well as decreased cost per live birth. Therefore, it was concluded that treatment of couples with unexplained infertility with gonadotropin/IUI was of no additional benefit.

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