Clinical significance of the tumor markers CYFRA 21-1 and neuron-specific enolase in lung cancer

1997 ◽  
Vol 123 (1) ◽  
pp. 85-87
Author(s):  
N. E. Kushlinskii ◽  
N. V. Lyubimova ◽  
A. O. Lemeshko ◽  
A. V. Vasil’ev ◽  
M. I. Davydov
Keyword(s):  
Lung Cancer ◽  
Tumor Markers ◽  
Clinical Significance ◽  
Neuron Specific Enolase

scholarly journals Clinical significance of circulating tumor cells and tumor markers in the diagnosis of lung cancer

2019 ◽  
Vol 8 (8) ◽  
pp. 3782-3792 ◽  
Author(s):  
Yang Li ◽  
Xudong Tian ◽  
Lei Gao ◽  
Xiaohong Jiang ◽  
Rao Fu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Tumor Markers ◽  
Clinical Significance ◽  
Diagnosis Of Lung Cancer

The diagnostic value of the combination of carcinoembryonic antigen, squamous cell carcinoma-related antigen, CYFRA 21-1, neuron-specific enolase, tissue polypeptide antigen, and progastrin-releasing peptide in small cell lung cancer discrimination

2021 ◽  
pp. 172460082110494
Author(s):  
Zhimao Chen ◽  
Xiangzheng Liu ◽  
Xueqian Shang ◽  
Kang Qi ◽  
Shijie Zhang
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Tumor Markers ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Neuron Specific Enolase ◽  
Small Cell ◽  
Small Cell Lung

Background The diagnostic value of six tumor markers was investigated and the appropriate combinations of those tumor markers to discriminate small cell lung cancer was explored. Methods Patients suspected with lung cancer (1938) were retrospectively analyzed. Candidate tumor markers from carcinoembryonic antigen (CEA), squamous cell carcinoma-related antigen (SCC), cytokeratin 19 fragment 21-1 (CYFRA 21-1), neuron-specific enolase (NSE), tissue polypeptide antigen (TPA), and progastrin releasing peptide (ProGRP) were selected to construct a logistic regression model. The receiver operating characteristic curve was used for evaluating the diagnostic value of the tumor markers and the predictive model. Results ProGRP had the highest positive rate (72.3%) in diagnosed small cell lung cancer, followed by neuron-specific enolase (68.3%), CYFRA21-1 (50.5%), carcinoembryonic antigen (45.5%), tissue polypeptide antigen (30.7%), and squamous cell carcinoma-related antigen (5.9%). The predictive model for small cell lung cancer discrimination was established, which yielded the highest area under the curve (0.888; 95% confidence interval: 0.846–0.929), with a sensitivity of 71.3%, a specificity of 95.0%, a positive predictive value of 49.0%, and a negative predictive value of 98.0%. Conclusions Combining tumor markers can improve the efficacy for small cell lung cancer discrimination. A predictive model has been established in small cell lung cancer differential diagnosis with preferable efficacy.

Clinical Significance of the Number of Positive Tumor Markers in Assisting the Diagnosis of Lung Cancer with Multiple Tumor Marker Assay

Oncology ◽  
1990 ◽  
Vol 47 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Yutaka Mizushima ◽  
Hitoshi Hirata ◽  
Saburo Izumi ◽  
Kiyoshi Hoshino ◽  
Keiko Konishi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Marker ◽  
Tumor Markers ◽  
Clinical Significance ◽  
Multiple Tumor ◽  
Diagnosis Of Lung Cancer ◽  
Marker Assay

How to Express Tumor Markers in Bronchoalveolar Lavage

2004 ◽  
Vol 19 (1) ◽  
pp. 67-71
Author(s):  
F.J. Caro Gómez de Terreros ◽  
R. Álvarez-Sala ◽  
M.C. Prados ◽  
L. Callol ◽  
F.J. Gómez de Terreros Sínchez ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bronchoalveolar Lavage ◽  
Tumor Markers ◽  
Total Protein ◽  
Respiratory Diseases ◽  
Specific Antigen ◽  
Neuron Specific Enolase ◽  
Roc Curves ◽  
Lavage Fluid ◽  
Cancer Tumor

Introduction Bronchoalveolar lavage (BAL) is a fundamental technique in the diagnosis of different respiratory diseases including lung cancer. Tumor marker values can be determined in the BAL fluid, but controversy still exists about how to express the results. Objective The aim of this study was to determine the best method of expressing tumor markers in BAL, either referring to total proteins or volume of fluid recovered. Patients and Methods A prospective, randomized, non-blind study was carried out. Seventy-six patients (72 men and 4 women) diagnosed with lung cancer and 17 subjects without respiratory disease were included. BAL was performed in all patients and the fluid retrieved was divided into two fractions: a bronchiolar fraction (F0) and an alveolar fraction (F1). Five tumor markers: cytokeratin fragment 19 (CYFRA 21–1), squamous cell carcinoma antigen (SCC), tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and neuron-specific enolase (NSE) as well as total protein were measured in both fractions. The concentrations were expressed in relation to the volume of BAL fluid recovered (ng or mU/mL) and in milligrams of total protein of lavage fluid (ng or mU/mg TP). The SPSS 11.01 software was used for statistical analysis. Mann-Whitney U test and ROC curves were developed when significant differences were found. Results We found significant differences in the CYFRA 21-1 values in the two BAL fractions and in both ways of expressing its concentration; in SCC in F1 expressed in ng/mg TP; in TPA in F0 expressed in mU/mg TP; in TPS in both fractions expressed in mU/mg TP, and in NSE in both fractions in ng/mg TP. The markers that best differentiated tumors from controls (ROC curves) were CYFRA 21-1 in F0 and NSE in both fractions in ng/mg TP. Conclusions Our study demonstrates that the concentrations of tumor markers in BAL expressed in relation to total protein were more effective than if expressed in mL of BAL fluid collected.

Clinical significance of serum basic fetoprotein and various tumor markers in primary lung cancer

1998 ◽  
Vol 3 (4) ◽  
pp. 216-222
Author(s):  
Takahiko Horiguchi ◽  
Souichi Tachikawa ◽  
Seishi Tamaki ◽  
Masashi Doi
Keyword(s):  
Lung Cancer ◽  
Tumor Markers ◽  
Clinical Significance ◽  
Primary Lung Cancer ◽  
Basic Fetoprotein

scholarly journals Clinical Significance of Serum BFP and Various Tumor Markers in Primary Lung Cancer.

Haigan ◽  
1994 ◽  
Vol 34 (1) ◽  
pp. 37-45
Author(s):  
Takahiko Horiguchi ◽  
Souichi Tachikawa ◽  
Seisi Tamaki ◽  
Makoto Kato ◽  
Masashi Doi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Markers ◽  
Clinical Significance ◽  
Primary Lung Cancer

Use of Tumor Markers in Lung Cancer

1994 ◽  
Vol 8 (3) ◽  
pp. 507-532 ◽  
Author(s):  
Gary M. Strauss ◽  
Arthur T. Skarin
Keyword(s):  
Lung Cancer ◽  
Tumor Markers
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