scholarly journals Skeletal muscle glucose transporter gene expression is not affected by injecting growth-hormone-secreting cells in young rats

Diabetologia ◽  
1993 ◽  
Vol 36 (6) ◽  
pp. 475-480 ◽  
Author(s):  
H. Imamura ◽  
I. Morimoto ◽  
S. Etoh ◽  
T. Usa ◽  
H. Namba ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Hormone ◽  
Glucose Transporter ◽  
Transporter Gene ◽  
Young Rats

scholarly journals Glucose transporter gene expression in rat conceptus during high glucose culture

Diabetologia ◽  
1993 ◽  
Vol 36 (8) ◽  
pp. 696-706 ◽  
Author(s):  
Y. Takao ◽  
S. Akazawa ◽  
K. Matsumoto ◽  
H. Takino ◽  
M. Akazawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Glucose ◽  
Glucose Transporter ◽  
Transporter Gene

scholarly journals Dairy cows experience selective reduction of the hepatic growth hormone receptor during the periparturient period

2004 ◽  
Vol 181 (2) ◽  
pp. 281-290 ◽  
Author(s):  
J Wook Kim ◽  
RP Rhoads ◽  
SS Block ◽  
TR Overton ◽  
SJ Frank ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Hormone ◽  
Dairy Cows ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Late Pregnancy ◽  
Target Tissue ◽  
Ghr Gene ◽  
Igf I

At parturition, dairy cows experience a 70% reduction in plasma IGF-I. This reduction coincides with decreased abundance of GHR1A, the liver-specific transcript of the growth hormone receptor (GHR) gene, suggesting impaired growth hormone-dependent synthesis of IGF-I. It is not immediately obvious that the periparturient reduction in GHR1A is sufficient to reduce hepatic GHR abundance. This is because approximately 50% of total GHR mRNA abundance in prepartum liver is accounted for by ubiquitously expressed transcripts which remain collectively unchanged at parturition. In addition, the possibility that parturition alters GHR expression in other growth hormone target tissue has not been examined. To address these questions, we measured GHR gene expression and GHR protein in liver and skeletal muscle of four dairy cows on days -35,+3 and+56 (relative to parturition on day 0). Hepatic GHR abundance and GHR1A transcripts were lower on day+3 than on day -35 and returned to late pregnancy value by day+56. Additional studies in two other groups of cows indicated that the hepatic levels of the GHR protein recovered substantially within 10 days after parturition. These changes occurred without variation in the abundance of HNF4, a liver-enriched transcription factor activating the promoter responsible for GHR1A synthesis. In contrast to liver, levels of GHR gene expression and GHR protein were identical on days -35,+3 and+56 in skeletal muscle. These data suggest a role for the GHR in regulating tissue-specific changes in growth hormone responsiveness in periparturient dairy cows.

scholarly journals FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone

2016 ◽  
Vol 26 ◽  
pp. 36-41 ◽  
Author(s):  
Suman Srinivasa ◽  
Caroline Suresh ◽  
Jay Mottla ◽  
Sulaiman R. Hamarneh ◽  
Javier E. Irazoqui ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Hormone ◽  
Mitochondrial Function ◽  
Igf I
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