The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system

1996 ◽  
Vol 13 (2) ◽  
pp. 155-183 ◽  
Author(s):  
Franco Folli ◽  
Silvana Ghidella ◽  
Luca Bonfanti ◽  
C. Ronald Kahn ◽  
Adalberto Merighi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Intracellular Signaling ◽  
Growth Factor Receptor ◽  
Insulin Like Growth Factor ◽  
Intracellular Signaling Pathway ◽  
Mammalian Central Nervous System ◽  
Receptor Family

scholarly journals ROLE OF INSULIN-LIKE GROWTH FACTOR IN DEPRESSION: A REVIEW

2021 ◽  
Vol 12 (3) ◽  
pp. 6-10
Author(s):  
Rutu M Patel ◽  
Digvijaysinh G Rana
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Neural Plasticity ◽  
Neurotrophic Factors ◽  
Growth Factor Receptor ◽  
Unknown Origin ◽  
Insulin Like Growth Factor ◽  
Physiological Processes

Depression is a disorder of unknown origin and it involves disturbance of many physiological processes. There are many mechanisms in depression including alterations in neurotrophic factors. It has been suggested in this review that an impairment of synaptic plasticity in specific areas of central nervous system, specifically in hippocampus can be an important factor in the pathophysiology of depression. Further, an abnormal neural plasticity may be related to alterations in the level of neurotrophic factors. In context with this, it can be suggested that there can be a connection between occurrences of depression with the disturbance of neurotrophic factors, raising great attention in the recent years. In the present review, it has been tried to explain the significance of insulin-like growth factor in depression by presenting the several important topics such as neurotrophic factors in depression, insulin like growth factor in central nervous system, insulin like growth factor receptor in depression, neurotrophic role of insulin like growth factor and correlation between insulin like growth factor and brain serotonin levels.

scholarly journals Determination of Alkali-Sensing Parts of the Insulin Receptor-Related Receptor Using the Bioinformatic Approach

Acta Naturae ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 80-86 ◽  
Author(s):  
I. E. Deyev ◽  
N. V. Popova ◽  
A. G. Petrenko
Keyword(s):  
Growth Factor ◽  
Insulin Receptor ◽  
Growth Factor Receptor ◽  
Ph Sensitive ◽  
Effective Concentration ◽  
The Body ◽  
Insulin Like Growth Factor ◽  
Extracellular Region ◽  
Half Maximal Effective Concentration ◽  
Receptor Family

IRR (insulin receptor-related receptor) is a receptor tyrosine kinase belonging to the insulin receptor family, which also includes insulin receptor and IGF-IR receptor. We have previously shown that IRR is activated by extracellular fluid with pH 7.9 and regulates excess alkali excretion in the body. We performed a bioinformatic analysis of the pH-sensitive potential of all three members of the insulin receptor family of various animal species (from frog to man) and their chimeras with swapping of different domains in the extracellular region. An analysis using the AcalPred program showed that insulin receptor family proteins are divided into two classes: one class with the optimal working pH in the acidic medium (virtually all insulin receptor and insulin-like growth factor receptor orthologs, except for the IGF-IR ortholog from Xenopus laevis) and the second class with the optimal working pH in the alkaline medium (all IRR orthologs). The program had predicted that the most noticeable effect on the pH-sensitive property of IRR would be caused by the replacement of the L1 and C domains in its extracellular region, as well as the replacement of the second and third fibronectin repeats. It had also been assumed that replacement of the L2 domain would have the least significant effect on the alkaline sensitivity of IRR. To test the in silico predictions, we obtained three constructs with swapping of the L1C domains, the third L2 domain, and all three domains L1CL2 of IRR with similar domains of the insulin-like growth factor receptor. We found that replacement of the L1C and L1CL2 domains reduces the receptors ability to be activated with alkaline pH, thus increasing the half-maximal effective concentration by about 100%. Replacement of the L2 domain increased the half-maximal effective concentration by 40%. Thus, our results indicate the high predictive potential of the AcalPred algorithm, not only for the pH-sensitive enzymes, but also for pH-sensitive receptors.

The Biological Role of Truncated Insulin-like Growth Factor-1 and the Tripeptide GPE in the Central Nervous System

1993 ◽  
Vol 692 (1 The Role of I) ◽  
pp. 183-191 ◽  
Author(s):  
VICKI R. SARA ◽  
C. CARLSSON-SKWIRUT ◽  
K. DRAKENBERG ◽  
M. B. GIACOBINI ◽  
L. HÅKANSSON ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Biological Role ◽  
Insulin Like Growth Factor ◽  
The Central Nervous System
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