Pulmonary function and bronchial reactivity in asthmatics during low-level formaldehyde exposure

Lung ◽  
1990 ◽  
Vol 168 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Henrik Harving ◽  
Jens Korsgaard ◽  
Ole Find Pedersen ◽  
Lars Mølhave ◽  
Ronald Dahl
Keyword(s):  
Pulmonary Function ◽  
Bronchial Reactivity ◽  
Low Level ◽  
Formaldehyde Exposure

scholarly journals Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142816 ◽  
Author(s):  
Cristiane Miranda da Silva ◽  
Mayara Peres Leal ◽  
Robson Alexandre Brochetti ◽  
Tárcio Braga ◽  
Luana Beatriz Vitoretti ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Lung Inflammation ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Formaldehyde Exposure

Effects of a Brief Low-Level Exposure to the Particulate Fraction of Diesel Exhaust on Pulmonary Function of Conscious Sheep

1980 ◽  
Vol 35 (2) ◽  
pp. 77-80 ◽  
Author(s):  
William M. Abraham ◽  
Chong S. Kim ◽  
Adolph J. Januszkiewicz ◽  
Matthew Welker ◽  
Mary Ann Mingle ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Diesel Exhaust ◽  
Particulate Fraction ◽  
Low Level ◽  
Conscious Sheep

scholarly journals Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Lauren H. Wyatt ◽  
Robert B. Devlin ◽  
Ana G. Rappold ◽  
Martin W. Case ◽  
David Diaz-Sanchez
Keyword(s):  
Particulate Matter ◽  
Pulmonary Function ◽  
Adhesion Molecule ◽  
Human Exposure ◽  
Fine Particulate Matter ◽  
Ambient Air ◽  
P Wave ◽  
Low Level ◽  
Link Type ◽  
Fine Particulate

Abstract Background Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. Methods To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, young volunteers to PM2.5, in the form of concentrated ambient particles (mean: 37.8 μg/m3, SD 6.5), and filtered air (mean: 2.1 μg/m3, SD 2.6). In this double-blind, crossover study the exposure order was randomized. During the 4 h exposure, volunteers (7 females and 13 males) underwent light intensity exercise to regulate ventilation rate. We measured pulmonary, cardiac, and hematologic end points before exposure, 1 h after exposure, and again 20 h after exposure. Results Low-level PM2.5 resulted in both pulmonary and extra-pulmonary changes characterized by alterations in systematic inflammation markers, cardiac repolarization, and decreased pulmonary function. A mean increase in PM2.5 concentration (37.8 μg/m3) significantly increased serum amyloid A (SAA), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1), 1 h after exposure by 8.7, 9.1, 10.7, and 6.6%, respectively, relative to the filtered air control. SAA remained significantly elevated (34.6%) 20 h after PM2.5 exposure which was accompanied by a 5.7% decrease in percent neutrophils. Decreased pulmonary function was observed 1 h after exposure through a 0.8 and 1.2% decrease in forced expiratory volume in 1 s (FEV1) and FEV1/ forced vital capacity (FEV1/FVC) respectively. Additionally, sex specific changes were observed in repolarization outcomes following PM2.5 exposure. In males, P-wave and QRS complex were increased by 15.4 and 5.4% 1 h after exposure. Conclusions This study is the first controlled human exposure study to demonstrate biological effects in response to exposure to concentrated ambient air PM2.5 particles at levels near the PM2.5 US NAAQS standard. Clinical trial registration information clinicaltrials.gov; Identifier: NCT03232086. The study was registered retrospectively on July 25, 2017, prior to final data collection on October 25, 2017 and data analysis.

Repeated low level formaldehyde exposure produces enhanced fear conditioning to odor in male, but not female, rats

2004 ◽  
Vol 1008 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Barbara A. Sorg ◽  
Samantha Swindell ◽  
Matthew L. Tschirgi
Keyword(s):  
Fear Conditioning ◽  
Female Rats ◽  
Low Level ◽  
Formaldehyde Exposure
Sign in / Sign up

Export Citation Format

Share Document