Role of matrix metalloprotease-2 in oxidant activation of Ca2+ATPase by hydrogen peroxide in pulmonary vascular smooth muscle plasma membrane

2003 ◽  
Vol 28 (2) ◽  
pp. 205-213 ◽  
Author(s):  
Malay ManDal ◽  
Sudip Das ◽  
Tapati Chakraborti ◽  
Amritlal ManDal ◽  
Sajal Chakraborti
Keyword(s):  
Hydrogen Peroxide ◽  
Smooth Muscle ◽  
Plasma Membrane ◽  
Vascular Smooth Muscle ◽  
Matrix Metalloprotease ◽  
Muscle Plasma Membrane

scholarly journals Mechanism of vascular smooth muscle cells activation by hydrogen peroxide: role of phospholipase C gamma

2002 ◽  
Vol 17 (3) ◽  
pp. 392-398 ◽  
Author(s):  
Francisco R. González‐Pacheco ◽  
Carlos Caramelo ◽  
Maria Ángeles Castilla ◽  
Juan J. P. Deudero ◽  
Javier Arias ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Phospholipase C ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Phospholipase C Gamma

scholarly journals Role of arginine residues in the stimulation of the smooth-muscle plasma-membrane Ca2+ pump by negatively charged phospholipids

1989 ◽  
Vol 264 (2) ◽  
pp. 609-612 ◽  
Author(s):  
L Missiaen ◽  
L Raeymaekers ◽  
G Droogmans ◽  
F Wuytack ◽  
R Casteels
Keyword(s):  
Smooth Muscle ◽  
Plasma Membrane ◽  
Phosphatidic Acid ◽  
Muscle Plasma Membrane ◽  
Low Concentrations ◽  
Important Interaction ◽  
Arginine Residues ◽  
Acidic Phospholipids ◽  
Stimulation Of

Negatively charged phospholipids strongly stimulate the purified plasma membrane Ca2+ pump of erythrocytes [Enyedi, Flura, Sarkadi, Gardos & Carafoli (1987) J. Biol. Chem. 262, 6425-6430] and of smooth muscle [Missiaen, Raeymaekers, Wuytack, Vrolix, De Smedt & Casteels, (1989) Biochem. J. 263, 687-694]. We have investigated the role of arginine residues in the interaction of these acidic phospholipids with the smooth-muscle Ca2+ transport ATPase. The arginine-modifying reagent phenylglyoxal inhiibited the ATPase activity in a time-dependent fashion by decreasing the Vmax. of the Ca2(+)-activation curve. Low concentrations of PtdIns, PtdIns4P, PtdIns(4,5) P2, phosphatidylserine and phosphatidic acid partially prevented this inactivation. This protective effect was however not apparent at higher concentrations of PtdIns4P, PtdIns(4,5) P2 and phosphatidic acid, which may be related to the previously observed inhibition of the enzyme at higher concentrations of these phospholipids. These findings indicate that the functionally important interaction of the acidic lipids with the protein occurs at least partially via arginine residue(s).

scholarly journals TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential‐dependent coupling with PTEN

2019 ◽  
Vol 33 (9) ◽  
pp. 9785-9796 ◽  
Author(s):  
Takuro Numaga‐Tomita ◽  
Tsukasa Shimauchi ◽  
Sayaka Oda ◽  
Tomohiro Tanaka ◽  
Kazuhiro Nishiyama ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Plasma Membrane ◽  
Membrane Potential ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Phenotypic Switching ◽  
Plasma Membrane Potential
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