Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician’s point of view

2003 ◽  
Vol 62 (1-2) ◽  
pp. 101-109 ◽  
Author(s):  
Aidnag Z. Diaz
Keyword(s):  
Phase I ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
National Laboratory ◽  
Brookhaven National Laboratory ◽  
Point Of View ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Boron Neutron Capture Therapy of Glioblastoma Multiforme at Brook haven National Laboratory: Results of the Phase I/II Trial

Neurosurgery ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 677-677
Author(s):  
Eric H. Elowitz ◽  
Jacek Capala ◽  
Manjeet Chadha ◽  
Douglas S. Cohen ◽  
Jeffrey A. Coderre ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Phase I ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
National Laboratory ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Laboratory Results

Boron Neutron Capture Therapy for Glioblastoma Multiforme: Interim Results from the Phase I/II Dose-Escalation Studies

Neurosurgery ◽  
1999 ◽  
Vol 44 (6) ◽  
pp. 1182-1193 ◽  
Author(s):  
Arjun D. Chanana ◽  
Jacek Capala, ◽  
Manjeet Chadha ◽  
Jeffrey A. Coderre ◽  
Aidnag Z. Diaz ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Phase I ◽  
Dose Escalation ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Implications of radiation microdosimetry for accelerator-based boron neutron capture therapy: a radiobiological perspective

2020 ◽  
Vol 93 (1111) ◽  
pp. 20200311
Author(s):  
Hisanori Fukunaga ◽  
Yusuke Matsuya ◽  
Koichi Tokuuye ◽  
Motoko Omura
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Potential ◽  
Biological Effects ◽  
Point Of View ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Medical Institutions ◽  
Biological Effectiveness ◽  
Underlying Mechanisms

Boron neutron capture therapy (BNCT) has great potential to selectively destroy cancer cells while sparing surrounding normal cells. The basic concept of BNCT was developed in the 1930s, but it has not yet been commonly used in clinical practice, even though there is now a large number of experimental and translational studies demonstrating its marked therapeutic potential. With the development of neutron accelerators that can be installed in medical institutions, accelerator-based BNCT is expected to become available at several medical institutes around the world in the near future. In this commentary, from the point of view of radiation microdosimetry, we discuss the biological effects of BNCT, especially the underlying mechanisms of compound biological effectiveness. Radiobiological perspectives provide insight into the effectiveness of BNCT in creating a synergy effect in the field of clinical oncology.

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