Tartrate-resistant acid phosphatase as a marker of bone metastases in patients with breast cancer and prostate cancer

2004 ◽  
Vol 138 (7) ◽  
pp. 77-79 ◽  
Author(s):  
N. V. Lyubimova ◽  
M. V. Pashkov ◽  
S. A. Tyulyandin ◽  
V. E. Gol’dberg ◽  
N. E. Kushlinskii
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Acid Phosphatase ◽  
Bone Metastases ◽  
Tartrate Resistant Acid Phosphatase

scholarly journals Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases

Endocrinology ◽  
2016 ◽  
Vol 157 (12) ◽  
pp. 4526-4533 ◽  
Author(s):  
Alexander Kirschenbaum ◽  
Sudeh Izadmehr ◽  
Shen Yao ◽  
Kieley L. O’Connor-Chapman ◽  
Alan Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Acid Phosphatase ◽  
Bone Metastases ◽  
Cross Talk ◽  
Bone Cells ◽  
Bone Mineralization ◽  
Critical Role ◽  
Prostatic Acid Phosphatase ◽  
Bone Lesions ◽  
Rankl Expression

Prostate cancer (PCa) is unique in its tendency to produce osteoblastic (OB) bone metastases. There are no existing therapies that specifically target the OB phase that affects 90% of men with bone metastatic disease. Prostatic acid phosphatase (PAP) is secreted by PCa cells in OB metastases and increases OB growth, differentiation, and bone mineralization. The purpose of this study was to investigate whether PAP effects on OB bone metastases are mediated by autocrine and/or paracrine alterations in the receptor activator of nuclear factor κ-B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. To investigate whether PAP modulated these factors and altered the bone reaction, we knocked down PAP expression in VCaP cells and stably overexpressed PAP in PC3M cells, both derived from human PCa bone metastases. We show that knockdown of PAP in VCaP cells decreased OPG while increasing RANK/RANKL expression. Forced overexpression of PAP in PC3M cells had the inverse effect, increasing OPG while decreasing RANK/RANKL expression. Coculture of PCa cells with MC3T3 preosteoblasts also revealed a role for secretory PAP in OB-PCa cross talk. Reduced PAP expression in VCaP cells decreased MC3T3 proliferation and differentiation and reduced their OPG expression. PAP overexpression in PC3M cells altered the bone phenotype creating OB rather than osteolytic lesions in vivo using an intratibial model. These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases OPG and plays a critical role in the vicious cross talk between cancer and bone cells. These data suggest that inhibition of secretory PAP may be an effective strategy for PCa OB bone lesions.

scholarly journals Serum tartrate-resistant acid phosphatase 5b activity as a prognostic marker of survival in breast cancer with bone metastasis

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Yi-Ying Wu ◽  
Anthony J Janckila ◽  
Chih-Hung Ku ◽  
Cheng-Ping Yu ◽  
Jyh-Cherng Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Acid Phosphatase ◽  
Bone Metastasis ◽  
Prognostic Marker ◽  
Tartrate Resistant Acid Phosphatase

scholarly journals Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Anja Reithmeier ◽  
Elena Panizza ◽  
Michael Krumpel ◽  
Lukas M. Orre ◽  
Rui M. M. Branca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Acid Phosphatase ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tartrate Resistant Acid Phosphatase
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