Introduction: One of the chronic progressive diseases of the elderly is Osteoarthritis. There is a wide spectrum of Nutraceuticals, for Osteoarthritis,
but there does not exist, a convincing literature based evidence, in support of their denitive and specic rationale of utility. We here in, aim to
evaluate the evidence in literature hither to available, for establishing the potency and efcaciousness of the indigenous type II collagen variant.
Methods: st st A schematic search was performed of Pub Med, Scopus and the Google Scholar, from dates (1 December 2009 to 1 December 2020),
with the search terms: 'Osteoarthritis', 'Nutraceuticals', 'Oral Collagen', 'Glucosamine', 'Chondroitin Sulfate', 'Acetaminophen' and 'Native
Collagen'. Articles containing the following were included in the study: Randomized Control Trial and Clinical Trial, Primary data, OA and Oral
Collagen studies related to joint disease. Total number of patients studied, the number of patients who were treated by Native Collagen Type II
variant, Denatured Collagen Type II variant, Glucosamine, Chondroitin Sulfate and Acetaminophen.A number of studies using various scoring
systems were incorporated in our study. Finally, all the functional outcomes, according to the VAS and WOMAC scores, were cumulatively
tabulated, and analyzed schematically and their results deduced.
Results: Multiple researches have been executed, to elucidate upon the efcacy and the safety, of Oral Collagen of the type II variant, in the
medicaments prescribed for OA, especially relating to the Knee joint. Oral Collagen is administered, either in a Denatured or an Undenatured form
.The results indicate , that out of all the Nutraceuticals, Undenatured/Native collagen of the type II variant, proved to be by far the most safe and
signicantly more efcacious, compared to other Nutraceuticals. Although all the suggested treatments reduced the WOMAC and the VAS scores,
here in UC II, showed more efciency and sustenance of the pain reduction, in both the assessment scores, in comparison with other orally
administrated Nutraceuticals.
Conclusion: Our Meta-Analysis concludes that, Type II Undenatured Collagen, is a relatively safe and also signicantly more efcient, in
improving the joint function, ROM and for the alleviation of bone joint pain, in OA knee (Genu OA) patients.
Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix