International society for rheumatic therapy guest society symposium: Recent therapeutic experiences with new generation drugs for inflammatory diseases

2002 ◽  
Vol 51 (2) ◽  
pp. 73-75 ◽  
Author(s):  
B. White
Keyword(s):  
International Society ◽  
Inflammatory Diseases ◽  
Society Symposium ◽  
Therapeutic Experiences ◽  
New Generation

scholarly journals Antibiotic-associated diarrhea in children: how to identify, what to do and how to treat?

2016 ◽  
Vol 1 (1) ◽  
pp. 78-89
Author(s):  
I. N. Zakharova ◽  
I. V. Berezhnaya ◽  
E. B. Mumladze
Keyword(s):  
High Risk ◽  
Antibiotic Therapy ◽  
Intestinal Microbiota ◽  
High Probability ◽  
Pseudomembranous Colitis ◽  
Inflammatory Diseases ◽  
Pediatric Practice ◽  
Antibiotic Associated Diarrhea ◽  
New Generation ◽  
Very High

Rational antibiotic therapy is one of the most important components in the treatment of children with various infectious and inflammatory diseases. However, wide and sometimes unjustified use of AB in pediatric practice often leads to the development of a variety of complications. Children receiveing AB, especially during the first 5 years of life, are at a very high risk of developing antibiotic-associated diarrhea (AAD) which manifests itself in three or more episodes of unformed stools for two or more consecutive days or for 8 weeks after withdrawal. The most relevant pathogen of AAD is C. difficile which, according to various data, causes from 10 to 25% of AAD cases and 90 to 100% of all cases of pseudomembranous colitis (PMC). Given the high probability of developing dangerous complications such as PMC, special attention should be paid to the prevention of the infection associated with C. difficile by reducing the frequency of uncontrolled and unjustified use of AB. A new generation of eco-antibiotics can be recommended which allow to maintain diversity of the intestinal microbiota and are less likely to cause complications.

scholarly journals Non-specific chronic vaginites in women of the industrial center and ways of their correction

2019 ◽  
pp. 17-21
Author(s):  
Наталья Резниченко ◽  
Галина Резниченко ◽  
Анатолий Дюдюн
Keyword(s):  
Inflammatory Diseases ◽  
Antibacterial Properties ◽  
Pathological Process ◽  
Reproductive Age ◽  
Cervical Canal ◽  
Industrial City ◽  
Vaginal Microflora ◽  
Propionic Acid Bacteria ◽  
Study Evaluation ◽  
New Generation

Insufficient effectiveness of antibacterial and anti­inflammatory therapy dictates the need to find new ways of prevention and treatment of chronic recurrent inflammatory diseases of the vagina and cervix in women with the use of new generation multiprobiotics. Objective of the study: evaluation of the effectiveness of the use of a multipropiotic drug with propolis in the treatment of recurrent bacterial vaginitis in women of reproductive age - residents of a large industrial city. Materials and methods of the study: 69 patients aged 18 - 45 years with bacterial vaginitis living in the large industrial city of Zaporizhzhya were observed. The main group consisted of 14 women with inflammatory diseases of the vagina and cervix, who received in the complex treatment of multiprobiotics with propolis 1 dose 1 time a day in the vagina for 5 days. To determine the presence of an infec­tious agent, microscopic and bacteriological examination of vaginal and cervical canal secretions was performed, the species composition of pathogens was determined by PCR. Results of the study and their discussion. In patients with chronic vaginitis of reproductive age living in the conditions of a large industrial city there are pro­found disorders of the relationship between obligate and pathogenic microorganisms, which contributes to the re­currence of the pathological process. Conclusions. The use of a multiprobiotic drug with propolis, which has a broad antiviral and antibacterial properties, containing bifido, lacto, propionic acid bacteria and propolis can ef­fectively normalize the vaginal microflora in chronic vagi­nitis, shorten the development time and treatment. The results of the study give us grounds to recommend the widespread use of a propolis-based multipropiotic drug for women suffering from chronic vaginitis who are not amenable to standard anti-inflammatory therapy.

scholarly journals The Dark Matter of Human Microbiota: Virobiota and Virome

2021 ◽  
Author(s):  
Gülendam Bozdayı ◽  
Işıl Fidan
Keyword(s):  
High Throughput Sequencing ◽  
Inflammatory Diseases ◽  
Human Microbiome ◽  
Endogenous Retroviruses ◽  
Therapeutic Approaches ◽  
Sequencing Technologies ◽  
Health And Disease ◽  
New Generation Sequencing ◽  
New Generation ◽  
Generation Sequencing

The viral component of the human microbiome is referred as ‘virobiota’. The virobiota is the sum of all viruses found in or on humans. The set of all genes of virobiota is referred as ‘virome’. The human virome consists of virus-derived genetic elements found in human genome constituted of viruses that infect eukaryotic cells, bacteriophages, prokaryotic cells, and, endogenous retroviruses. The development of new sequencing technologies, such as high-throughput sequencing techniques allowed the analysis of the human virome. Many new viruses have been discovered lately, using new generation sequencing technology. In recent years, there has been an increase in the studies of the human virome as changes in virome have been observed in diseases. The alterations in the human virome may be associated with infectious, inflammatory diseases, cancer and autoimmunity. The understanding of how the virome affects human health and disease can provide the development of potential therapeutic approaches that target the members of the virome.

scholarly journals Global network of computational biology communities: ISCB's Regional Student Groups breaking barriers

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1574 ◽  
Author(s):  
Sayane Shome ◽  
R. Gonzalo Parra ◽  
Nazeefa Fatima ◽  
Alexander Miguel Monzon ◽  
Bart Cuypers ◽  
...  
Keyword(s):  
Computational Biology ◽  
International Society ◽  
Global Network ◽  
Future Directions ◽  
Student Groups ◽  
Biology Student ◽  
Student Council ◽  
Bioinformatics Education ◽  
New Generation ◽  
Bioinformatics Community

Regional Student Groups (RSGs) of the International Society for Computational Biology Student Council (ISCB-SC) have been instrumental to connect computational biologists globally and to create more awareness about bioinformatics education. This article highlights the initiatives carried out by the RSGs both nationally and internationally to strengthen the present and future of the bioinformatics community. Moreover, we discuss the future directions the organization will take and the challenges to advance further in the ISCB-SC main mission: “Nurture the new generation of computational biologists”.

Interintestinal Anastomoses With New Generation Of Circular - Stapling Instrument Supporting At Surgical Treatment Of Inflammatory-Ulcer Diseases Of The Colon.

2010 ◽  
Vol 1 ◽  
Author(s):  
B Navruzov ◽  
S Abdujabbarov ◽  
S Rahmonov
Keyword(s):  
Surgical Treatment ◽  
Postoperative Complications ◽  
Conservative Therapy ◽  
Ileorectal Anastomosis ◽  
Inflammatory Diseases ◽  
Operation Time ◽  
Actual Problem ◽  
New Generation

Surgical treatment of inflammatory diseases of intestine remains actual problem, despite the progress of conservative therapy. In our research it was etablished,  applying low and ultralow ileorectal anastomosis with circular - stapling apparatus allows to reach reliability of the generated anastomoses, it is essential reduce operation time, reduce number of postoperative complications and reduce duration of patients stay in hospital.

scholarly journals Nanoparticles and Inflammation

2011 ◽  
Vol 11 ◽  
pp. 1300-1312 ◽  
Author(s):  
Ross Stevenson ◽  
Axel J. Hueber ◽  
Alan Hutton ◽  
Iain B. McInnes ◽  
Duncan Graham
Keyword(s):  
Inflammatory Diseases ◽  
Molecular Probes ◽  
Disease States ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Cellular Recruitment ◽  
Enhanced Raman Scattering ◽  
New Methodologies ◽  
Magnetic Resonance Imaging Mri ◽  
New Generation

The development of nanoscale molecular probes capable of diagnosis, characterization, and clinical treatment of disease is leading to a new generation of imaging technologies. Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. This suggests that nanoparticle techniques may provide excellent biomarkers for the diagnosis and progression of inflammatory diseases with magnetic resonance imaging (MRI), fluorescent quantum dots (QDs), and surface enhanced Raman scattering (SERS) probes being just some of the new methodologies employed. Development of these techniques could lead to a range of sensitive probes capable of ultrasensitive, localized detection of inflammation. This article will discuss the merits of each approach, with a general overview to their applicability in inflammatory diseases.

scholarly journals Whole-body MRI: comprehensive evaluation on a 48-channel 3T MRI system in less than 40 minutes. Preliminary results

2012 ◽  
Vol 45 (6) ◽  
pp. 319-325 ◽  
Author(s):  
Mateus de Andrade Hernandes ◽  
Richard C. Semelka ◽  
Jorge Elias Júnior ◽  
Saraporn Bamrungchart ◽  
Brian M. Dale ◽  
...  
Keyword(s):  
Image Quality ◽  
Comprehensive Evaluation ◽  
Inflammatory Diseases ◽  
Pulmonary Arteries ◽  
Vena Cava ◽  
Observer Agreement ◽  
Whole Body ◽  
Hepatic Veins ◽  
Single Shot ◽  
New Generation

OBJECTIVE: To evaluate a comprehensive MRI protocol that investigates for cancer, vascular disease, and degenerative/inflammatory disease from the head to the pelvis in less than 40 minutes on a new generation 48-channel 3T system. MATERIALS AND METHODS: All MR studies were performed on a 48-channel 3T MR scanner. A 20-channel head/neck coil, two 18-channel body arrays, and a 32-channel spine array were employed. A total of 4 healthy individuals were studied. The designed protocol included a combination of single-shot T2-weighted sequences, T1-weighted 3D gradient-echo pre- and post-gadolinium. All images were retrospectively evaluated by two radiologists independently for overall image quality. RESULTS: The image quality for cancer was rated as excellent in the liver, pancreas, kidneys, lungs, pelvic organs, and brain, and rated as fair in the colon and breast. For vascular diseases ratings were excellent in the aorta, major branch vessel origins, inferior vena cava, portal and hepatic veins, rated as good in pulmonary arteries, and as poor in the coronary arteries. For degenerative/inflammatory diseases ratings were excellent in the brain, liver and pancreas. The inter-observer agreement was excellent. CONCLUSION: A comprehensive and time efficient screening for important categories of disease processes may be achieved with high quality imaging in a new generation 48-channel 3T system.

Immunotherapeutic Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities

2018 ◽  
Vol 25 (36) ◽  
pp. 4785-4806 ◽  
Author(s):  
Nirmala Chandralega Kampan ◽  
Sue D. Xiang ◽  
Orla M. McNally ◽  
Andrew N. Stephens ◽  
Michael A. Quinn ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Large Scale ◽  
Inflammatory Cytokine ◽  
Inflammatory Diseases ◽  
Disease Stabilisation ◽  
Conventional Chemotherapy ◽  
Challenges And Opportunities ◽  
Interleukin 6 Receptor ◽  
New Generation ◽  
Soluble Gp130

Interleukin 6 (IL-6), a well-known pro-inflammatory cytokine with pleiotropic activity is a central player in chronic inflammatory diseases including cancers. Therefore, blockade of the IL-6 signalling pathway has become a target for the therapy of diverse cancers such as multicentric Castleman’s disease (CD), multiple myeloma and solid tumours including renal, prostate, lung, colorectal and ovarian cancers. Monoclonal antibodies against IL-6 (Siltuximab) and the IL-6 receptor (IL-6R) (Tocilizumab) have emerged as potential immunotherapies, alone or in combination with conventional chemotherapy. Human trials have demonstrated the ability to block IL-6 activity and in multicentric CD lead to durable clinical response and longer disease stabilisation. However, the efficacy of these treatments is still debatable for other cancers. New generation therapeutics in development such as Clazakizumab, Sarilumab, and soluble gp130-Fc have the additional features of improved binding affinity, better specificity with reduced adverse effects. A deeper understanding of the immunological basis of these agents, as well as of the challenges that are faced by immunotherapy-based products in clinical trials, will help select the most promising anti-IL-6/IL-6R therapies for large scale use. Concurrently, current research efforts to personalize treatments may help in the treatment of patients that would greatly benefit from IL-6 blocking therapies.

scholarly journals Trichomonal vaginitis: what should be done?

2019 ◽  
pp. 5-10
Author(s):  
Галина Резниченко ◽  
Наталья Резниченко ◽  
Анатолий Дюдюн
Keyword(s):  
Quality Of Life ◽  
Trichomonas Vaginalis ◽  
Treatment Time ◽  
Inflammatory Diseases ◽  
Antibacterial Properties ◽  
Pathological Process ◽  
Vaginal Microflora ◽  
New Generation ◽  
Trichomonas Vaginitis

The lack of effectiveness of antibacterial and anti-in­flammatory therapy dictates the need to find new ways of treating mixed inflammatory diseases of the vagina in women with the use of new generation antibiotics. Mate­rials and methods of research. There were 72 patients aged 17 - 36 years with trichomonas vaginitis living in the city of Zaporizhzhya under observation. All women un­derwent a general clinical examination, three times (up to, 2 weeks and 3 months after the start of treatment) microscopic and bacteriological examination of vaginal discharge. The effectiveness of therapy was evaluated 3 months after the start of treatment. Results of the study and their discussion. Patients with trichomonas vagini­tis have profound disorders of the relationship between obligate and pathogenic microorganisms, which contrib­utes to the recurrence of the pathological process and deterioration of quality of life. Conclusions: in the treat­ment of trichomonas vaginitis, the effectiveness of a drug containing ornidazole is better than that of metronidazole. Combined use of antibacterial drugs with ornidazole and ornidazole, neomycin sulfate, nystatin, prednisolone, with broad antibacterial properties and activity against Trichomonas vaginalis, Entamoeba histolytica, Giardia lacbia intestisis, Fardi intubisides (Fardium intestisis, fid- ium intestisis) and anaerobic cocci, effectively normalize the vaginal microflora indices in bacterial - fungal - tricho­monas vaginitis, shorten the treatment time, prevent the development of relapses in the future, thereby improving the quality of life of patients.

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