A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events

1997 ◽  
Vol 23 (2) ◽  
pp. 111-121 ◽  
Author(s):  
Kimberly A. Walker ◽  
C. Darrell Jennings ◽  
Joseph Pulliam ◽  
Charles Ogburn ◽  
George M. Martin ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cell Line ◽  
Loss Of Heterozygosity ◽  
Cross Resistance ◽  
Mutator Phenotype ◽  
Genotoxic Agents ◽  
A Cell ◽  
Resistance To Ionizing Radiation

Cross-Resistance to Ionizing Radiation in a Murine Leukemic Cell Line Resistant tocis-Dichlorodiammineplatinum(II): Role of Ku Autoantigen

1999 ◽  
Vol 56 (1) ◽  
pp. 141-146 ◽  
Author(s):  
Philippe Frit ◽  
Yvan Canitrot ◽  
Catherine Muller ◽  
Nicolas Foray ◽  
Patrick Calsou ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cell Line ◽  
Leukemic Cell ◽  
Cross Resistance ◽  
Leukemic Cell Line ◽  
Ku Autoantigen ◽  
Resistance To Ionizing Radiation

Aberrant Type C Virus Production in a Cell Line Derived from Balb/3T3

1972 ◽  
Vol 30 ◽  
pp. 286-287
Author(s):  
N. Savage ◽  
A. Hackett
Keyword(s):  
Electron Microscopy ◽  
Cell Line ◽  
Leukemia Virus ◽  
Morphological Characteristics ◽  
Virus Production ◽  
Oncogenic Viruses ◽  
Endogenous Virus ◽  
Virus Particles ◽  
Moloney Leukemia Virus ◽  
A Cell

A cell line, UC1-B, which was derived from Balb/3T3 cells, maintains the same morphological characteristics of the non-transformed parental culture, and shows no evidence of spontaneous virus production. Survey by electron microscopy shows that the cell line consists of spindle-shaped cells with no unusual features and no endogenous virus particles.UC1-B cells respond to Moloney leukemia virus (MLV) infection by a change in morphology and growth pattern which is typical of cells transformed by sarcoma virus. Electron microscopy shows that the cells are now variable in shape (rounded, rhomboid, and spindle), and each cell type has some microvilli. Virtually all (90%) of the cells show virus particles developing at the cell surface and within the cytoplasm. Maturing viruses, typical of the oncogenic viruses, are found along with atypical tubular forms in the same cell.

Establishment of a cell line (HCC-M) from a human hepatocellular carcinoma

1983 ◽  
Vol 32 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Tetsu Watanabe ◽  
Toshio Morizane ◽  
Kanji Tsuchimoto ◽  
Yasutaka Inagaki ◽  
Yoshio Munakata ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Line ◽  
Human Hepatocellular Carcinoma ◽  
A Cell

scholarly journals Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics

Blood ◽  
1985 ◽  
Vol 65 (1) ◽  
pp. 21-31 ◽  
Author(s):  
RC Stong ◽  
SJ Korsmeyer ◽  
JL Parkin ◽  
DC Arthur ◽  
JH Kersey
Keyword(s):  
Acute Leukemia ◽  
Cell Line ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cell ◽  
Leukemic Cells ◽  
Leukemia Cell Line ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Immunoglobulin Gene ◽  
A Cell ◽  
B Lineage

Abstract A cell line, designated RS4;11, was established from the bone marrow of a patient in relapse with an acute leukemia that was characterized by the t(4;11) chromosomal abnormality. The cell line and the patient's fresh leukemic cells both had the t(4;11)(q21;q23) and an isochromosome for the long arm of No. 7. Morphologically, all cells were lymphoid in appearance. Ultrastructurally and cytochemically, approximately 30% of the cells possessed myeloid features. The cells were strongly positive for terminal deoxynucleotidyl transferase. They were HLA-DR positive and expressed surface antigens characteristic for B lineage cells, including those detected by anti-B4, BA-1, BA-2, and PI153/3. Immunoglobulin gene analysis revealed rearrangements of the heavy chain and kappa chain genes. The cells lacked the common acute lymphoblastic leukemia antigen and antigenic markers characteristic of T lineage cells. The cells reacted with the myeloid antibody 1G10 but not with other myeloid monoclonal antibodies. Treatment with 12-O-tetradecanoyl- phorbol-13-acetate induced a monocyte-like phenotype demonstrated by cytochemical, functional, immunologic, and electron microscopic studies. The expression of markers of both early lymphoid and early myeloid cells represents an unusual phenotype and suggests that RS4;11 represents a cell with dual lineage capabilities. To our knowledge, RS4;11 is the first cell line established from t(4;11)-associated acute leukemia.

Understanding the functions of tumor stroma in resistance to ionizing radiation: Emerging targets for pharmacological modulation

2013 ◽  
Vol 16 (1-2) ◽  
pp. 10-21 ◽  
Author(s):  
Cyrus Chargari ◽  
Céline Clemenson ◽  
Isabelle Martins ◽  
Jean-Luc Perfettini ◽  
Eric Deutsch
Keyword(s):  
Ionizing Radiation ◽  
Tumor Stroma ◽  
Pharmacological Modulation ◽  
Resistance To Ionizing Radiation

Characterization of a Cell Line Derived From a Human Giant Cell Tumor That Stimulates Osteoclastic Bone Resorption

1993 ◽  
Vol &NA; (296) ◽  
pp. 229???241 ◽  
Author(s):  
RICHARD O. C. OREFFO ◽  
G. JUNE MARSHALL ◽  
MARY KIRCHEN ◽  
CARLOS GARCIA ◽  
WOLF E. GALLWITZ ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Giant Cell Tumor ◽  
Cell Line ◽  
Giant Cell ◽  
Cell Tumor ◽  
Osteoclastic Bone Resorption ◽  
A Cell

Secretory Activity and Oncogenicity of a Cell Line (MDCK) Derived from Canine Kidneyand

Science ◽  
1969 ◽  
Vol 163 (3866) ◽  
pp. 472-473 ◽  
Author(s):  
J. Leighton ◽  
Z. Brada ◽  
L. W. Estes ◽  
G. Justh
Keyword(s):  
Cell Line ◽  
Secretory Activity ◽  
A Cell

Cellfile: A cell line databank for specialized catalogs

1993 ◽  
Vol 11 (S1) ◽  
pp. S134-S136
Author(s):  
E. Motti ◽  
L. Ventrella ◽  
V. Pistotti ◽  
T. Dasdia ◽  
A. Ghiozzi ◽  
...  
Keyword(s):  
Cell Line ◽  
A Cell
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