Tumor necrosis factor-α alters protein metabolism and cell-cycle kinetics in malignant tumor

1996 ◽  
Vol 8 (1) ◽  
pp. 19-22
Author(s):  
Ye Shenglong ◽  
Tang Zhaoyou ◽  
Bruce R Bistrian
Keyword(s):  
Cell Cycle ◽  
Tumor Necrosis Factor ◽  
Malignant Tumor ◽  
Protein Metabolism ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cell Cycle Kinetics ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

2014 ◽  
Vol 62 ◽  
pp. 273-285 ◽  
Author(s):  
Kiran Bhaskar ◽  
Nicole Maphis ◽  
Guixiang Xu ◽  
Nicholas H. Varvel ◽  
Olga N. Kokiko-Cochran ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Cycle ◽  
Alzheimer's Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Neuronal Cell ◽  
Factor Α ◽  
Necrosis Factor

Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor α

1996 ◽  
Vol 39 (7) ◽  
pp. 1115-1124 ◽  
Author(s):  
Laura C. Rall ◽  
Clifford J. Rosen ◽  
Gregory Dolnikowski ◽  
Wilburta J. Hartman ◽  
Nancy Lundgren ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Muscle Strength ◽  
Strength Training ◽  
Protein Metabolism ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Aging Effects ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Antiproliferative Effect of Tumor Necrosis Factor-α on Human Glioblastoma Cells Linked with Cell Cycle Arrest in G1 Phase

1994 ◽  
Vol 34 (5) ◽  
pp. 274-278 ◽  
Author(s):  
Kang CHENG ◽  
Yutaka SAWAMURA ◽  
Shirou SAKUMA ◽  
Mitsuhiro TADA ◽  
Masako SUDO ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Necrosis Factor ◽  
Cell Cycle Arrest ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Antiproliferative Effect ◽  
G1 Phase ◽  
Cycle Arrest ◽  
Factor Α ◽  
Necrosis Factor

Evaluation of antitumor effect of tumor necrosis factor in terms of protein metabolism and cell cycle kinetics

1993 ◽  
Vol 265 (2) ◽  
pp. C365-C374 ◽  
Author(s):  
J. M. Wan ◽  
F. Fogt ◽  
B. R. Bistrian ◽  
N. W. Istfan
Keyword(s):  
Cell Cycle ◽  
Tumor Necrosis Factor ◽  
Tumor Growth ◽  
Protein Metabolism ◽  
Tumor Necrosis ◽  
Compensatory Mechanism ◽  
Protein Breakdown ◽  
Cell Cycle Kinetics ◽  
Necrosis Factor

To determine the significance of protein breakdown in regulating tumor growth and to better understand the antitumor mechanism of tumor necrosis factor in vivo, we measured the effects of a 6-h constant intravenous infusion of human recombinant tumor necrosis factor-alpha (rHuTNF) on tumor protein metabolism and cell cycle kinetics in rats bearing the Walker-256 carcinosarcoma. Protein metabolism was investigated with the use of [14C]leucine infusion; estimates of tumor cell cycle kinetics were obtained in vivo by use of 5-bromo-2'-deoxyuridine (BrdUrd) pulse labeling and bivariate BrdUrd/DNA analysis by flow cytometry. Reduction in tumor growth by rHuTNF was associated with a dose-dependent increase in tumor proteolysis but no change in tumor protein synthesis. At the cellular level, rHuTNF had a significant cytostatic effect on G2/M cells and caused a marked decrease in the fraction of cells capable of BrdUrd uptake. Release of BrdUrd, an indicator of cell death, was noted in only 7.5% of tumor cells labeled at the beginning of rHuTNF infusion. These results suggest that either tumor protein breakdown may influence cell cycle activity by regulating cytoplasmic protein mass or that tumor proteolysis may be a compensatory mechanism for limiting cytoplasmic size when cellular division is interrupted suddenly.

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