Artificial organs and devices track: Prosthetic Heart Valves — New Directions

1996 ◽  
Vol 24 (1) ◽  
pp. S1-S9 ◽  
Keyword(s):  
Heart Valves ◽  
Artificial Organs ◽  
Prosthetic Heart Valves ◽  
New Directions

scholarly journals Elongational Stresses and Cells

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2352
Author(s):  
Kylie M. Foster ◽  
Dimitrios V. Papavassiliou ◽  
Edgar A. O’Rear
Keyword(s):  
Heart Valves ◽  
Cell Injury ◽  
Extensional Flow ◽  
Cross Flow ◽  
Food Product ◽  
Artificial Organs ◽  
Microfluidic Channels ◽  
Prosthetic Heart Valves ◽  
Shear Stresses ◽  
Cell Deformability

Fluid forces and their effects on cells have been researched for quite some time, especially in the realm of biology and medicine. Shear forces have been the primary emphasis, often attributed as being the main source of cell deformation/damage in devices like prosthetic heart valves and artificial organs. Less well understood and studied are extensional stresses which are often found in such devices, in bioreactors, and in normal blood circulation. Several microfluidic channels utilizing hyperbolic, abrupt, or tapered constrictions and cross-flow geometries, have been used to isolate the effects of extensional flow. Under such flow cell deformations, erythrocytes, leukocytes, and a variety of other cell types have been examined. Results suggest that extensional stresses cause larger deformation than shear stresses of the same magnitude. This has further implications in assessing cell injury from mechanical forces in artificial organs and bioreactors. The cells’ greater sensitivity to extensional stress has found utility in mechanophenotyping devices, which have been successfully used to identify pathologies that affect cell deformability. Further application outside of biology includes disrupting cells for increased food product stability and harvesting macromolecules for biofuel. The effects of extensional stresses on cells remains an area meriting further study.

The Effect of Dipyridamole and RA 233 on Human Platelet Function in Vitro

1973 ◽  
Vol 29 (03) ◽  
pp. 694-700 ◽  
Author(s):  
Paul L. Rifkin ◽  
Marjorie B. Zucker
Keyword(s):  
Mechanism Of Action ◽  
Human Blood ◽  
Glass Bead ◽  
Heart Valves ◽  
Human Platelet ◽  
Drug Effects ◽  
Simple Relation ◽  
Prosthetic Heart Valves ◽  
Induced Aggregation

SummaryDipyridamole (Persantin) is reported to prolong platelet survival and inhibit embolism in patients with prosthetic heart valves, but its mechanism of action is unknown. Fifty jxM dipyridamole failed to reduce the high percentage of platelets retained when heparinized human blood was passed through a glass bead column, but prolonged the inhibition of retention caused by disturbing blood in vitro. Possibly the prostheses act like disturbance. Although RA 233 was as effective as dipyridamole in inhibiting the return of retention, it was less effective in preventing the uptake of adenosine into erythrocytes, and more active in inhibiting ADP-induced aggregation and release. Thus there is no simple relation between these drug effects.

Erythrocyte Destruction by Prosthetic Heart Valves

Circulation ◽  
1968 ◽  
Vol 37 (4s2) ◽  
Author(s):  
ROBERT A. INDEGLIA ◽  
MICHAEL A. SHEA ◽  
RICHARD L. VARCO ◽  
EUGENE F. BERNSTEIN
Keyword(s):  
Heart Valves ◽  
Prosthetic Heart Valves ◽  
Erythrocyte Destruction

Local Anticoagulation of Prosthetic Heart Valves

Circulation ◽  
1973 ◽  
Vol 48 (1s3) ◽  
Author(s):  
MICHAEL L. SCHWARTZ ◽  
DEAN SHELDON ◽  
FRANK DORMAN ◽  
PERRY L. BLACKSHEAR ◽  
RICHARD L. VARCO ◽  
...  
Keyword(s):  
Heart Valves ◽  
Prosthetic Heart Valves

scholarly journals Ultra slow thrombolysis in dysfunctional prosthetic heart valves, a controversial technique in critically ill patients not candidates for surgery

2019 ◽  
Vol 25 ◽  
pp. 100421
Author(s):  
Noel Alberto Flórez ◽  
German Camilo Giraldo ◽  
Julian David Yara ◽  
Stephania Galindo-Coral ◽  
Juan David López ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Heart Valves ◽  
Prosthetic Heart Valves

scholarly journals Warfarin poisoning in patients with prosthetic heart valves.

BMJ ◽  
1981 ◽  
Vol 283 (6291) ◽  
pp. 581-582 ◽  
Author(s):  
F Toolis ◽  
R H Robson ◽  
J A Critchley
Keyword(s):  
Heart Valves ◽  
Prosthetic Heart Valves
Sign in / Sign up

Export Citation Format

Share Document