Hypotonic lysis of red blood cell contamination from human anterior pituitary adenoma cell preparations

1995 ◽  
Vol 31 (9) ◽  
pp. 657-658 ◽  
Author(s):  
S. L. Atkin ◽  
J. Radcliffe ◽  
L. Hipkin ◽  
M. C. White
Keyword(s):  
Pituitary Adenoma ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Anterior Pituitary ◽  
Adenoma Cell ◽  
Hypotonic Lysis ◽  
Human Anterior Pituitary

Human anterior pituitary adenoma cell attachment in vitro

1997 ◽  
Vol 33 (3) ◽  
pp. 158-160 ◽  
Author(s):  
S. L. Atkin ◽  
L. Hipkin ◽  
R. V. Jeffreys ◽  
P. M. Foy ◽  
M. C. White
Keyword(s):  
Pituitary Adenoma ◽  
Anterior Pituitary ◽  
Cell Attachment ◽  
Adenoma Cell ◽  
Human Anterior Pituitary

scholarly journals The Separate Existence of the Pituitary Erythropoietic Hormone

Blood ◽  
1957 ◽  
Vol 12 (6) ◽  
pp. 539-548 ◽  
Author(s):  
DONALD C. VAN DYKE ◽  
M. E. SIMPSON ◽  
A. N. CONTOPOULOS ◽  
H. M. EVANS
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Anterior Pituitary ◽  
Erythropoietic Activity ◽  
Cell Production ◽  
Number Of Factors ◽  
Satisfactory Method ◽  
Chemical Evidence ◽  
Trophic Hormones

Abstract Although it is recognized that a number of factors are involved in the mechanism controlling red blood cell production, the anterior pituitary furnishes one factor of importance. This pituitary factor is apparently a hormone distinct from other trophic hormones. It is allied chemically only to ACTH and yet both biological and chemical evidence indicates that the pituitary erythropoietic hormone and ACTH are not the same. The major problem in further elucidating the role of the pituitary in the control of erythropoiesis resolves itself into developing a satisfactory method of preparation of erythropoietic hormone which will separate it from ACTH. It is true that no ACTH preparation has been made which does not possess some erythropoietic activity, and no pituitary erythropoietic hormone has been prepared which is entirely devoid of ACTH. Nevertheless, the proportion of these two activities in different preparations has varied so greatly as to assure their separate existence. Autolytic digestion consistently reduces the ACTH activity, while erythropoietic activity is retained. It has been found that oxycellulose is a better adsorbent of ACTH than of erythropoietic hormone. These observations add chemical evidence to the accumulated biological evidence establishing the separate existence of these two pituitary principles.

Identification of proliferating human anterior pituitary adenoma cells in vitro

1997 ◽  
Vol 19 (4) ◽  
pp. 420-425 ◽  
Author(s):  
Stephen Atkin ◽  
Heather Burnett ◽  
Alexander Landolt ◽  
Victoria Green ◽  
Leslie Hipkin ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Anterior Pituitary ◽  
Human Anterior Pituitary

scholarly journals THE EFFECT OF ENDOCRINOPATHIES ON THE BLOOD

Blood ◽  
1948 ◽  
Vol 3 (12) ◽  
pp. 1342-1366 ◽  
Author(s):  
WILLIAM H. DAUGHADAY ◽  
ROBERT H. WILLIAMS ◽  
GENEVA A. DALAND
Keyword(s):  
Bone Marrow ◽  
Blood Cell ◽  
Replacement Therapy ◽  
Adrenal Cortex ◽  
Red Blood Cell ◽  
Anterior Pituitary ◽  
White Blood Cells ◽  
Hormonal Control ◽  
Blood Formation ◽  
Cell Series

Abstract Evidence has been presented that the gonads, thyroid, adrenal cortex and pituitary glands have a definite influence on blood formation. The normal sex difference in erythrocyte levels in animals, and probably in man, can be obliterated by castration and restored by appropriate replacement therapy. Hypothyroidism results in a moderately severe anemia in animals. In the uncomplicated form, the anemia is slightly macrocytic and associated with a hypoplastic bone marrow. In clinical experience the anemia may be complicated by the secondary effects of achylia gastrica leading either to iron deficiency or to a deficiency in the antipernicious anemia factor. Hyperthyroidism causes some alterations in the white blood cells, but has little effect on the red blood cell series. Hyperactive states of the adrenal cortex may be associated with a mild polycythemia. Adrenal steroids also have a marked lymphocytic effect, causing the release of beta and gamma globulins from lymphoid tissue. A mechanism involving the anterior pituitary and adrenal seems to exist, controlling the release of antibodies under certain conditions. It is suggested that other mechanisms also exist which control the number of circulating lymphocytes. Deficiency of the anterior pituitary secretions results in anemia in animals and man. The anemia in animals is usually microcytic and hypochromic and may respond to several types of replacement therapy. In man anemia develops slowly and is rarely severe. Moderate reductions in the red blood cell count occur and the color index varies. There is hypoplasia of the bone marrow. The anemia in man does not respond uniformly well to the therapy now available, but improvement often occurs with the replacement of "end-organ" hormones. The preponderance of evidence indicates that the regulation of blood formation is not primarily under hormonal control. The effects noted in various glandular disorders are due to alterations in metabolism produced in the bone marrow as well as all other body tissues.

Tissue inhibitors of metalloproteinase-expressing cells in human anterior pituitary and pituitary adenoma

2017 ◽  
Vol 50 (3) ◽  
pp. 145-154 ◽  
Author(s):  
Alimuddin Tofrizal ◽  
Ken Fujiwara ◽  
Morio Azuma ◽  
Motoshi Kikuchi ◽  
Depicha Jindatip ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Anterior Pituitary ◽  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteinase ◽  
Human Anterior Pituitary
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