Variation in the electrical properties of cultured human proximal tubule cells

1993 ◽  
Vol 29 (5) ◽  
pp. 371-378 ◽  
Author(s):  
John H. Todd ◽  
Mary Ann Sens ◽  
Debra J. Hazen-Martin ◽  
John E. Bylander ◽  
Brendan J. Smyth ◽  
...  
Keyword(s):  
Electrical Properties ◽  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule

scholarly journals Electrophysiology and ultrastructure of cultured human proximal tubule cells

1988 ◽  
Vol 33 (2) ◽  
pp. 508-516 ◽  
Author(s):  
John G. Blackburn ◽  
Debra J. Hazen-Martin ◽  
Carol J. Detrisac ◽  
Donald A. Sens
Keyword(s):  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule

scholarly journals Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently

Cells ◽  
2015 ◽  
Vol 4 (3) ◽  
pp. 234-252 ◽  
Author(s):  
Carolien Schophuizen ◽  
Joost Hoenderop ◽  
Rosalinde Masereeuw ◽  
Lambert Heuvel
Keyword(s):  
Proximal Tubule ◽  
Organic Cation ◽  
Uremic Toxins ◽  
Proximal Tubule Cells ◽  
Cation Uptake ◽  
Tubule Cells ◽  
Human Proximal Tubule

scholarly journals EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells

2020 ◽  
Vol 11 ◽  
Author(s):  
Lauren G. Douma ◽  
Kristen Solocinski ◽  
Sarah H. Masten ◽  
Dominique H. Barral ◽  
Sarah J. Barilovits ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Endothelin 1 ◽  
Non Coding Rna ◽  
Tubule Cells ◽  
Long Non Coding Rna ◽  
Human Proximal Tubule

scholarly journals Proinflammatory Cytokines and Potassium Channels in the Kidney

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Kazuyoshi Nakamura ◽  
Hikaru Hayashi ◽  
Manabu Kubokawa
Keyword(s):  
Proximal Tubule ◽  
Proinflammatory Cytokines ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Transepithelial Transport ◽  
Channel Activity ◽  
Proximal Tubule Cells ◽  
Cell Functions ◽  
Tubule Cells ◽  
Human Proximal Tubule

Proinflammatory cytokines affect several cell functions via receptor-mediated processes. In the kidney, functions of transporters and ion channels along the nephron are also affected by some cytokines. Among these, alteration of activity of potassium ion (K+) channels induces changes in transepithelial transport of solutes and water in the kidney, since K+channels in tubule cells are indispensable for formation of membrane potential which serves as a driving force for the transepithelial transport. Altered K+channel activity may be involved in renal cell dysfunction during inflammation. Although little information was available regarding the effects of proinflammatory cytokines on renal K+channels, reports have emerged during the last decade. In human proximal tubule cells, interferon-γshowed a time-dependent biphasic effect on a 40 pS K+channel, that is, delayed suppression and acute stimulation, and interleukin-1βacutely suppressed the channel activity. Transforming growth factor-β1 activated KCa3.1 K+channel in immortalized human proximal tubule cells, which would be involved in the pathogenesis of renal fibrosis. This review discusses the effects of proinflammatory cytokines on renal K+channels and the causal relationship between the cytokine-induced changes in K+channel activity and renal dysfunction.

The Functional Implications of Common Genetic Variation in CYP3A5 and ABCB1 in Human Proximal Tubule Cells

2015 ◽  
Vol 12 (3) ◽  
pp. 758-768 ◽  
Author(s):  
Noël Knops ◽  
Lambertus P. van den Heuvel ◽  
Rosalinde Masereeuw ◽  
Inge Bongaers ◽  
Henriëtte de Loor ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Proximal Tubule ◽  
Common Genetic Variation ◽  
Proximal Tubule Cells ◽  
Functional Implications ◽  
Tubule Cells ◽  
Human Proximal Tubule
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