Surface active N-acylglutamate: II. Physicochemical properties of long chain N-acylglutamic acids and their sodium salts

1972 ◽  
Vol 49 (3) ◽  
pp. 143-150 ◽  
Author(s):  
Masahiro Takehara ◽  
Hirofumi Moriyuki ◽  
Ippei Yoshimura ◽  
Ryonosuke Yoshida
Keyword(s):  
Physicochemical Properties ◽  
Sodium Salts ◽  
Surface Active ◽  
Long Chain

Surface active N-acylglutamate: III. Physicochemical properties of sodium long chain N-acylglutamates

1973 ◽  
Vol 50 (7) ◽  
pp. 227-229 ◽  
Author(s):  
M. Takehara ◽  
H. Moriyuki ◽  
A. Arakawa ◽  
I. Yoshimura ◽  
R. Yoshida
Keyword(s):  
Physicochemical Properties ◽  
Surface Active ◽  
Long Chain

Long-chain alkyltriazoles as antitumor agents: synthesis, physicochemical properties, and biological and computational evaluation

2014 ◽  
Vol 24 (1) ◽  
pp. 430-441 ◽  
Author(s):  
Vanessa Silva Gontijo ◽  
Michael Éder Oliveira ◽  
Rafael José Resende ◽  
Amanda Luisa Fonseca ◽  
Renata Rachide Nunes ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Antitumor Agents ◽  
Computational Evaluation ◽  
Long Chain

scholarly journals Mining of Gram-Negative Surface-Active Enzybiotic Candidates by Sequence-Based Calculation of Physicochemical Properties

2021 ◽  
Vol 12 ◽  
Author(s):  
Roberto Vázquez ◽  
Sofía Blanco-Gañán ◽  
Susana Ruiz ◽  
Pedro García
Keyword(s):  
Physicochemical Properties ◽  
Nearest Neighbors ◽  
Regulatory Agencies ◽  
Gram Negative Bacteria ◽  
Wild Type ◽  
Gram Negative ◽  
Bacterial Surface ◽  
Negative Surface ◽  
Surface Active ◽  
Phage Lysins

Phage (endo)lysins are nowadays one of the most promising ways out of the current antibiotic resistance crisis. Either as sole therapeutics or as a complement to common antibiotic chemotherapy, lysins are already entering late clinical phases to get regulatory agencies’ authorization. Even the old paradigm of the inability of lysins to attack Gram-negative bacteria from without has already been overcome in a variety of ways: either by engineering approaches or investigating the natural mechanisms by which some wild-type lysins are able to interact with the bacterial surface. Such inherent ability of some lysins has been linked to antimicrobial peptide (AMP)-like regions, which are, on their own, a significant source for novel antimicrobials. Currently, though, many of the efforts for searching novel lysin-based antimicrobial candidates rely on experimental screenings. In this work, we have bioinformatically analyzed the C-terminal end of a collection of lysins from phages infecting the Gram-negative genus Pseudomonas. Through the computation of physicochemical properties, the probability of such regions to be an AMP was estimated by means of a predictive k-nearest neighbors (kNN) model. This way, a subset of putatively membrane-interacting lysins was obtained from the original database. Two of such candidates (named Pae87 and Ppl65) were prospectively tested in terms of muralytic, bacteriolytic, and bactericidal activity. Both of them were found to possess an activity against Pseudomonas aeruginosa and other Gram-negative bacterial pathogens, implying that the prediction of AMP-like regions could be a useful approach toward the mining of phage lysins to design and develop antimicrobials or antimicrobial parts for further engineering.

Estimation of the effective number of — CH2 - groups in long-chain surface active agents

1974 ◽  
Vol 252 (5) ◽  
pp. 407-414 ◽  
Author(s):  
I. J. Lin ◽  
B. M. Moudgil ◽  
P. Somasundaran
Keyword(s):  
Effective Number ◽  
Surface Active Agents ◽  
Surface Active ◽  
Long Chain

A new type of surface-active organotransition metal complex: (long-chain alkyl substituted benzene)(cyclopentadienyl) iron(1+) cationic complexes

1988 ◽  
pp. 663 ◽  
Author(s):  
Shizuyoshi Sakai ◽  
Hidetoshi Kozawa ◽  
Yuichiro Yoshinaga ◽  
Kuniuo Kosugi ◽  
Shinichi Fukuzawa ◽  
...  
Keyword(s):  
Metal Complex ◽  
New Type ◽  
Surface Active ◽  
Long Chain

Lysis of Echinococcus granulosus by surface-active agents in bile and the role of this phenomenon in determining host specificity in helminths

1962 ◽  
Vol 156 (965) ◽  
pp. 553-572 ◽  
Keyword(s):  
Bile Acids ◽  
Host Specificity ◽  
Echinococcus Granulosus ◽  
Definitive Host ◽  
Deoxycholic Acid ◽  
Life Cycles ◽  
Sodium Salts ◽  
Lytic Effect ◽  
Surface Active Agents ◽  
Surface Active

An extract of ox bile was found to lyse protoscolices of Echinococcus granulosus and induce abnormal accumulations of cytoplasmic fat. This observation led to a study of the in vitro action of bile and bile salts on this organism. Bile from the following herbivores caused lysis and fat accumulations: hare, rabbit, ox, sheep, man; lysis did not occur with bile from the following carnivores: fox, dog, cat. Sodium salts of cholic, taurocholic and glycocholic had no observable effect. Sodium salts of deoxycholic, glycodeoxycholic and taurodeoxycholic (in order of effectiveness) had a lytic effect. As a rule, herbivore biles producing lysis were those described as being rich in deoxycholic acid, largely conjugated with glycine. Bile from the dog (the natural definitive host) is reported as being relatively poor in deoxycholic acid which in carnivores is largely linked with taurine. It is suggested that the nature, type of conjugation and concentration of bile acids may play (amongst other factors) a major role in determining host specificity for E . granulosus . This hypothesis may prove to be capable of further extension to include intestinal parasites in general and may represent a fundamental controlling factor in many helminth and protozoan life cycles. It follows that the molecular configuration of the exposed surfaces of a successfully established intestinal parasite must be such that it is not susceptible to attack by the lytic agents present in the bile of its definitive host. It is suggested that the mechanism of lysis may be related to the presence of mitochondria in the cestode cuticle since these structures are known to be readily fragmented by deoxycholate and surface active substances. Sodium oleate had a lytic effect similar to, but less rapid than, sodium deoxycholate. There is evidence that the deoxycholic acid content of carnivore bile which is related to the microflora of the gut may be increased by change to a herbivorous diet; if this result is confirmed, it may indicate a nutritional method for controlling E. granulosus in dogs and possibly other helminth infections. It is speculated that a survey of bile acids and bile soaps throughout the animal kingdom may reveal the existence of other surface-active agents with a more pronounced lytic effect on E. granulosus or other helminths, than the limited group of bile compounds examined here.

Physicochemical Properties of Long Chain Alkylated Imidazolium Based Chloride and Bis(trifluoromethanesulfonyl)imide Ionic Liquids

2017 ◽  
Vol 62 (10) ◽  
pp. 3084-3094 ◽  
Author(s):  
Nastaran Hazrati ◽  
Majid Abdouss ◽  
Ali Akbar Miran Beigi ◽  
Ali Asghar Pasban ◽  
Mahmoud Rezaei
Keyword(s):  
Ionic Liquids ◽  
Physicochemical Properties ◽  
Long Chain

scholarly journals Physicochemical Properties and Sensory Attributes of Medium- and Long-Chain Triacylglycerols (MLCT)-Enriched Bakery Shortening

2009 ◽  
Vol 4 (4) ◽  
pp. 587-596 ◽  
Author(s):  
Norlelawati Arifin ◽  
Ling-Zhi Cheong ◽  
Soo-Peng Koh ◽  
Kamariah Long ◽  
Chin-Ping Tan ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Sensory Attributes ◽  
Long Chain
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