Insulin-like growth factor-II receptor expression in normal and N-methyl-N′-nitro-nitrosoguanidine exposed cell lines: Assessment by flow cytometry

1993 ◽  
Vol 29 (2) ◽  
pp. 114-116
Author(s):  
William H. Thornton ◽  
Ruth S. MacDonald ◽  
Louise Barnett
Keyword(s):  
Flow Cytometry ◽  
Growth Factor ◽  
Cell Lines ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Exposed Cell

scholarly journals Histamine Suppresses Fibulin-5 and Insulin-like Growth Factor-II Receptor Expression in Melanoma

2008 ◽  
Vol 68 (6) ◽  
pp. 1997-2005 ◽  
Author(s):  
Zoltan Pos ◽  
Zoltan Wiener ◽  
Peter Pocza ◽  
Melinda Racz ◽  
Sara Toth ◽  
...  
Keyword(s):  
Growth Factor ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Factor Ii

Secretion of Noncomplexed ‘Big’ (10–18 kD) Forms of Insulin-Like Growth Factor-II by 12 Soft Tissue Sarcoma Cell Lines

1999 ◽  
Vol 52 (4) ◽  
pp. 178-185 ◽  
Author(s):  
Martin W. Elmlinger ◽  
Uta Rauschnabel ◽  
Ewa Koscielniak ◽  
Karin Weber ◽  
Michael B. Ranke
Keyword(s):  
Growth Factor ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Insulin Like Growth Factor ◽  
Sarcoma Cell ◽  
Factor Ii

Insulin-like growth factor II and androgen receptor expression in the prostate

2001 ◽  
Vol 86 (6) ◽  
pp. 731-735 ◽  
Author(s):  
V.J. Gnanapragasam ◽  
P.J. Mccahy ◽  
D.E. Neal ◽  
C.N. Robson
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Factor Ii

Mannose-6-phosphate/Insulin-like Growth Factor II Receptor Expression and Tumor Development

2006 ◽  
Vol 26 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Eric Hébert
Keyword(s):  
Growth Factor ◽  
Cell Surface ◽  
Receptor Gene ◽  
Tumor Development ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Loss Of Function ◽  
Major Function ◽  
Factor Ii ◽  
Mannose 6 Phosphate

The mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR) is a multi-functional transmembrane glycoprotein whose major function is to bind and transport M6P-bearing glycoproteins from the trans-Golgi network or the cell surface to lysosomes. The cell surface M6P/IGF-IIR also bind and internalizes the insulin-like growth factor II. The receptor gene is considered a « candidate » tumor suppressor gene. The phenotypic consequences of loss of M6P/IGF-IIR through somatic mutation are potentially very complex since M6P/IGF-IIR has a number of roles in cellular physiology. Loss of function mutations in M6P/IGF-IIR gene could contribute to multi-step carcinogenesis. In the light of the multi-functional cellular potential roles of the M6P/IGF-IIR the purpose of this review is to highlight some recent data concerning its normal functions and the potential role of its loss in tumor pathophysiology with the aim to try to clarify the possible underlying mechanisms of its involvement in tumor development.

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