Coronary blood flow in chronic insulin-dependent diabetic dogs

1989 ◽  
Vol 26 (4) ◽  
pp. 275-282 ◽  
Author(s):  
Kent W. Small ◽  
Einar Stefansson ◽  
Diane L. Hatchell
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Insulin Dependent ◽  
Diabetic Dogs ◽  
Insulin Dependent Diabetic

Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen
Keyword(s):  
Blood Flow ◽  
Inverse Correlation ◽  
Diabetic Patients ◽  
Resistance Vessels ◽  
Head Up Tilt ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Type 1 Diabetic Patients ◽  
Term Type

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.

scholarly journals Regional variation in skin blood flow response to hypoglycaemia in Type 1 (insulin-dependent) diabetic patients without complications

Diabetologia ◽  
1988 ◽  
Vol 31 (2) ◽  
pp. 98-102 ◽  
Author(s):  
P. G. Wiles ◽  
P. J. Grant ◽  
M. H. Stickland ◽  
H. G. Dean ◽  
J. K. Wales ◽  
...  
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Regional Variation ◽  
Diabetic Patients ◽  
Blood Flow Response ◽  
Flow Response ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 ◽  
Vol 85 (6) ◽  
pp. 687-693 ◽  
Author(s):  
T. G. Elliott ◽  
J. R. Cockcroft ◽  
P.-H. Groop ◽  
G. C. Viberti ◽  
J. M. Ritter
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Relaxing Factor ◽  
Healthy Control ◽  
Insulin Dependent ◽  
Endothelium Derived Relaxing Factor ◽  
Insulin Dependent Diabetic

1. Microalbuminuria is a risk factor for cardiovascular disease in patients with insulin-dependent diabetes mellitus, and may be a marker of microvascular dysfunction including endothelial damage. The purpose of this study was to determine whether vasoconstrictor responses to NG-monomethyl-L-arginine, an inhibitor of endothelium-derived relaxing factor/nitric oxide biosynthesis, differ between healthy subjects and insulin-dependent patients with or without microalbuminuria. 2. Twenty-eight insulin-dependent diabetic patients (14 with normal albumin excretion, 14 with microalbuminuria) were studied under euglycaemic conditions, together with 14 healthy control subjects. Forearm vascular responses to brachial artery infusions of NG-monomethyl-L-arginine, sodium nitroprusside (an endothelium-independent nitrovasodilator) and carbachol (an endothelium-dependent vasodilator) were determined by strain gauge plethysmography. 3. Basal blood flow and vasodilator responses were similar in each group. NG-Monomethyl-L-arginine reduced blood flow by 41.3 + 2.3% (mean + SEM) in healthy control subjects, 34.0 + 3.4% in diabetic patients without microalbuminuria and 29.2 + 2.0% in diabetic patients with microalbuminuria. Diabetic patients differed from healthy subjects (P = 0.005), due to a difference between control subjects and microalbuminuric diabetic patients (P <0.001). NG-Monomethyl-L-arginine did not influence nitroprusside responses but reduced carbachol responses in control subjects and normoalbuminuric diabetic patients but not in microalbuminuric diabetic patients. 4. These results provide evidence of abnormal endothelium-derived relaxing factor/nitric oxide biosynthesis in insulin-dependent diabetic patients with microalbuminuria.

Resting and exercise hyperemic pulsatile arterial blood flow in insulin-dependent diabetic subjects

Diabetes ◽  
1983 ◽  
Vol 32 (7) ◽  
pp. 664-669 ◽  
Author(s):  
L. N. Cunningham ◽  
C. Labrie ◽  
J. S. Soeldner ◽  
R. E. Gleason
Keyword(s):  
Blood Flow ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic
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