Coxsackievirus B infection in the mouse: Effects associated with the diabetes gene, db

1979 ◽  
Vol 3 (1) ◽  
pp. 15-19 ◽  
Author(s):  
S. R. Webb ◽  
R. M. Loria ◽  
G. E. Madge ◽  
Sidney Kibrick
Keyword(s):  
Coxsackievirus B ◽  
Diabetes Gene

Obesity and Diabetes Gene Discovery Approaches

2003 ◽  
Vol 9 (17) ◽  
pp. 1357-1372 ◽  
Author(s):  
K. Walder ◽  
D. Segal ◽  
J. Jowett ◽  
J. Blangero ◽  
G. Collier
Keyword(s):  
Gene Discovery ◽  
Obesity And Diabetes ◽  
Diabetes Gene

Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas

2020 ◽  
Vol 16 (5) ◽  
pp. 677-688 ◽  
Author(s):  
Sandra Piras ◽  
Paola Corona ◽  
Roberta Ibba ◽  
Federico Riu ◽  
Gabriele Murineddu ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Antiviral Activity ◽  
Wide Spectrum ◽  
Immunocompromised Patients ◽  
Human Pathogen ◽  
Alkyl Aryl ◽  
Dna Viruses ◽  
Coxsackievirus B ◽  
Selective Activity

Background: Coxsackievirus infections are associated with cases of aseptic meningitis, encephalitis, myocarditis, and some chronic disease. Methods: A series of benzo[d][1,2,3]triazol-1(2)-yl derivatives (here named benzotriazol-1(2)-yl) (4a-i, 5a-h, 6a-e, g, i, j and 7a-f, h-j) were designed, synthesized and in vitro evaluated for cytotoxicity and antiviral activity against two important human enteroviruses (HEVs) members of the Picornaviridae family [Coxsackievirus B 5 (CVB-5) and Poliovirus 1 (Sb-1)]. Results: Compounds 4c (CC50 >100 μM; EC50 = 9 μM), 5g (CC50 >100 μM; EC50 = 8 μM), and 6a (CC50 >100 μM; EC50 = 10 μM) were found active against CVB-5. With the aim of evaluating the selectivity of action of this class of compounds, a wide spectrum of RNA (positive- and negativesense), double-stranded (dsRNA) or DNA viruses were also assayed. For none of them, significant antiviral activity was determined. Conclusion: These results point towards a selective activity against CVB-5, an important human pathogen that causes both acute and chronic diseases in infants, young children, and immunocompromised patients.

scholarly journals MiR‐205 is upregulated in islets of diabetes‐susceptible mice and targets the diabetes gene Tcf7l2

2021 ◽  
Author(s):  
Meriem Ouni ◽  
Pascal Gottmann ◽  
Efraim Westholm ◽  
Kristin Schwerbel ◽  
Markus Jähnert ◽  
...  
Keyword(s):  
Diabetes Gene

Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

1996 ◽  
Vol 4 (5) ◽  
pp. 175-179 ◽  
Author(s):  
Steven Tracy ◽  
Nora M. Chapman ◽  
José Romero ◽  
Arlene I. Ramsingh
Keyword(s):  
Heart Muscle ◽  
Muscle Disease ◽  
Coxsackievirus B

Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene

1999 ◽  
Vol 105 (4) ◽  
pp. 354-359 ◽  
Author(s):  
K.R. Bowles ◽  
J. Gibson ◽  
J. Wu ◽  
L.G. Shaffer ◽  
J.A. Towbin ◽  
...  
Keyword(s):  
Genomic Organization ◽  
Chromosomal Localization ◽  
Receptor Gene ◽  
Coxsackievirus B ◽  
Adenovirus Receptor

Coxsackievirus B cardiopathy and angiopathy in the hypercholesterolemic host

1978 ◽  
Vol 31 (3) ◽  
pp. 295-306 ◽  
Author(s):  
Ann E. Campbell ◽  
Roger M. Loria ◽  
Gordon E. Madge
Keyword(s):  
Coxsackievirus B

An Outbreak of Coxsackievirus B Infection Followed by One Case of Diabetes Mellitus

1985 ◽  
Vol 17 (1) ◽  
pp. 15-18 ◽  
Author(s):  
Bo S. Niklasson ◽  
Michael J. Dobersen ◽  
Clarence J. Peters ◽  
Willis H. Ennis ◽  
Erna Möller
Keyword(s):  
Diabetes Mellitus ◽  
Coxsackievirus B

Enteric resistance and coxsackievirus B

1977 ◽  
Vol 30 (11) ◽  
pp. 1871-1875
Author(s):  
S Kibrick ◽  
R M Loria
Keyword(s):  
Coxsackievirus B
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