Pyogenic granulomas, port-wine stains and laser therapy

1988 ◽  
Vol 3 (1-4) ◽  
pp. 7-11 ◽  
Author(s):  
S. W. Lanigan ◽  
J. A. Cotterill
Keyword(s):  
Laser Therapy ◽  
Port Wine ◽  
Port Wine Stains

scholarly journals In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 591
Author(s):  
Mingjuan Li ◽  
M. Ingmar van Raath ◽  
Shervin Khakpour ◽  
Ahmet Seçilir ◽  
Bart C. Sliggers ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Experimental Treatment ◽  
Port Wine ◽  
Site Specific ◽  
Port Wine Stains ◽  
Antifibrinolytic Drugs ◽  
Thermosensitive Liposomes ◽  
Local Release

Antifibrinolytic site-specific pharmaco-laser therapy (SSPLT) is an experimental treatment modality for refractory port wine stains (PWS). Conceptually, antifibrinolytic drugs encapsulated in thermosensitive liposomes are delivered to thrombi that form in semi-photocoagulated PWS blood vessels after conventional laser treatment. Local release of antifibrinolytics is induced by mild hyperthermia, resulting in hyperthrombosis and complete occlusion of the target blood vessel (clinical endpoint). In this study, 20 thermosensitive liposomal formulations containing tranexamic acid (TA) were assayed for physicochemical properties, TA:lipid ratio, encapsulation efficiency, and endovesicular TA concentration. Two candidate formulations (DPPC:DSPE-PEG, DPPC:MPPC:DSPE-PEG) were selected based on optimal properties and analyzed for heat-induced TA release at body temperature (T), phase transition temperature (Tm), and at T > Tm. The effect of plasma on liposomal stability at 37 °C was determined, and the association of liposomes with platelets was examined by flow cytometry. The accumulation of PEGylated phosphocholine liposomes in laser-induced thrombi was investigated in a hamster dorsal skinfold model and intravital fluorescence microscopy. Both formulations did not release TA at 37 °C. Near-complete TA release was achieved at Tm within 2.0–2.5 min of heating, which was accelerated at T > Tm. Plasma exerted a stabilizing effect on both formulations. Liposomes showed mild association with platelets. Despite positive in vitro results, fluorescently labeled liposomes did not sufficiently accumulate in laser-induced thrombi in hamsters to warrant their use in antifibrinolytic SSPLT, which can be solved by coupling thrombus-targeting ligands to the liposomes.

Acquired Port-Wine Stain in a Pediatric Patient

2006 ◽  
Vol 10 (3) ◽  
pp. 151-153 ◽  
Author(s):  
F. Sule Afsar ◽  
Ragıp Ortac
Keyword(s):  
Literature Review ◽  
Laser Therapy ◽  
Pediatric Patient ◽  
Pediatric Patients ◽  
Sun Exposure ◽  
Vascular Lesions ◽  
Port Wine Stain ◽  
Port Wine ◽  
Left Forearm ◽  
Port Wine Stains

Background: Acquired port-wine stains (PWSs) are vascular lesions that are identical to congenital PWSs morphologically and histopathologically. Objective: Because acquired PWSs are rarely seen in adult and pediatric patients, we present a 9-year-old boy with an acquired PWS on his left forearm. Conclusion: None of the proposed etiologies, such as trauma, chronic sun exposure, or hormonal medication, was applicable to our patient, and a literature review showed us that acquired PWSs give a faster and better response to pulsed dye laser therapy than congenital lesions do.

Long-Term Psychological Impact and Perceived Efficacy of Pulsed-Dye Laser Therapy for Patients With Port-Wine Stains

2003 ◽  
Vol 29 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Kristen Hansen ◽  
Clarence D Kreiter ◽  
Marcy Rosenbaum ◽  
Duane C Whitaker ◽  
Christopher J Arpey
Keyword(s):  
Laser Therapy ◽  
Psychological Impact ◽  
Dye Laser ◽  
Pulsed Dye Laser ◽  
Port Wine ◽  
Perceived Efficacy ◽  
Port Wine Stains

Argon Laser Therapy of Port-Wine Stains

1985 ◽  
Vol 75 (4) ◽  
pp. 520-525 ◽  
Author(s):  
Akira Yanai ◽  
Osatnu Fukuda ◽  
Shinichi Soyano ◽  
Osami Takayama ◽  
Tsuyoshi Kataigi
Keyword(s):  
Laser Therapy ◽  
Argon Laser ◽  
Port Wine ◽  
Port Wine Stains
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