Messung der Knochendurchblutung mit der „tracer microspheres“-Methode

1978 ◽  
Vol 4 (4) ◽  
pp. 253-255 ◽  
Author(s):  
K. -G. Kunze ◽  
J. Kraus ◽  
B. Winkler ◽  
B. Wüsten
Keyword(s):  
Tracer Microspheres

The Effect Of Streptokinase On Regional Myocardial Perfusion After Coronary Ligation In Dog

1981 ◽  
Author(s):  
K Genth ◽  
M Hofmann ◽  
W Schaper
Keyword(s):  
Heart Rate ◽  
Myocardial Perfusion ◽  
Coronary Arteries ◽  
Ischemic Myocardium ◽  
Collateral Flow ◽  
Dilution Technique ◽  
Regional Myocardial Perfusion ◽  
Coronary Ligation ◽  
Tracer Microspheres ◽  
Ischemic Muscle

The Influence of streptokinase(SK) on myocardial perfusion in ischemic and non-ischemic muscle was studied in 10 open-chest dogs, on each animal a sequential occlusion of 2 medium-sized coronary arteries was performed (90 min.), followed by reperfusion. Each dog served as its own control. After occlusion and reperfusion of the control artery (CA), the inital dose of SK was given (1,5 mega IU/20 min.). Thereafter test artery (TA) was occluded, followed by a maintenance dose of SK (500.000 IU/h). LVP, AOP, LVdp/dt and heart rate were recorded, MV02 was calculated by the computer (Bretschneider’s equation). Myocardial perfusion was measured after 90 min. of occlusion (tracer microspheres). M VO2 was comparable during both occlusion periods. CO (dye dilution technique) was 1,38±0,2 during CA-occlusion and 1,71±0,3 1/min. during TA-occlusion (p<0,01). In the non ischemic myocardium subepicardial and subendocardial perfusion was of equal value in both perfusion areas. Coronary ligation reduced flow drastically in the CA-region collateral flow (CF) in subendocardium was 11,8 ± 8 and 31,4 ± 12 ml/min.x100 g in the subepicardium. In The TA-region CF in the subendocardjum was 12,6 ± 5 and in the subepicardium 27,8 ± 14 ml/min.x100 g. CF was in the subendocardium significantly lower than in subepicardium in both perfusion areas (p<0,01). The present results show that CF in the ischemic myocardium cannot be modified by fibrinolysis. SK did not redistribute flow from subepicardium to subendocardium.

Effects of histamine receptor stimulation on regional myocardial blood flow

1983 ◽  
Vol 245 (3) ◽  
pp. H461-H467 ◽  
Author(s):  
C. W. Christensen ◽  
G. J. Gross ◽  
H. F. Hardman ◽  
H. L. Brooks ◽  
D. C. Warltier
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Histamine Receptor ◽  
Regional Myocardial Blood Flow ◽  
Intracoronary Infusion ◽  
H2 Antagonist ◽  
Tracer Microspheres ◽  
Anesthetized Dogs ◽  
H1 Antagonist ◽  
Regional Myocardial Blood

The effect of histamine (H) and specific H1 and H2 agonists and antagonists on regional myocardial blood flow was studied in anesthetized dogs by use of tracer microspheres. Intracoronary infusion of histamine (15 and 34 micrograms/min) produced a dose-related increase in transmural myocardial blood flow (from 0.82 to 1.36 and 2.25 ml X min-1 X g-1) without alteration of heart rate or blood pressure. Infusion of the H1 agonist 2-(2-thiazolyl)ethylamine (135 and 442 micrograms/min) produced an increase in transmural perfusion (from 0.69 to 1.22 and 1.65 ml X min-1 X g-1) and a significant (P less than 0.05) increase in the ratio of flow between subendocardium and subepicardium (endo/epi from 0.97 to 1.31 and 1.54). Infusion of the H2 agonist dimaprit (195 and 390 micrograms/min) produced an increase in transmural myocardial blood flow (from 0.97 to 1.49 and 2.00 ml X min-1 X g-1) without a change in endo/epi. The H1-mediated increase in regional myocardial perfusion and endo/epi was blocked by the H1 antagonist diphenhydramine but not by the H2 antagonist cimetidine. These results suggest that stimulation of H1 coronary receptors preferentially distributes flow to the subendocardium, whereas H2 receptors mediate vasodilation in subepicardium as well as subendocardium.

Durchblutungsmessungen an frei transplantierten Rippen-und Beckenkammspänen mit der Tracer-microspheres-Methode

1985 ◽  
Vol 11 (2) ◽  
pp. 55-57 ◽  
Author(s):  
L. Faupel ◽  
K. Kunze ◽  
H. Kafurke ◽  
B. Winkler
Keyword(s):  
Tracer Microspheres

Tissue edema and loss of tracer microspheres in infarcted myocardium

1983 ◽  
Vol 78 (2) ◽  
pp. 124-130 ◽  
Author(s):  
H. Tomoike ◽  
H. Ootsubo ◽  
K. Sakai ◽  
M. Nakamura
Keyword(s):  
Infarcted Myocardium ◽  
Tissue Edema ◽  
Tracer Microspheres

Tracer microspheres as compliance markers in clinical research

1984 ◽  
Vol 5 (4) ◽  
pp. 540-543 ◽  
Author(s):  
Robert L. Wolen ◽  
Ross E. Crabtree ◽  
Ralph H. Carmichael
Keyword(s):  
Clinical Research ◽  
Tracer Microspheres

scholarly journals Heterogeneities in regional volumes of distribution and flows in rabbit heart

1990 ◽  
Vol 258 (4) ◽  
pp. H1012-H1024 ◽  
Author(s):  
F. Gonzalez ◽  
J. B. Bassingthwaighte
Keyword(s):  
Rabbit Heart ◽  
Left Ventricular ◽  
Left Ventricular Cavity ◽  
Closed Chest ◽  
Vascular Space ◽  
Gamma Counting ◽  
Tracer Microspheres ◽  
Water Space ◽  
Volumes Of Distribution

The heterogeneity of volumes of distribution in the heart influences the rates of uptake and washout of substrates and metabolites; thus it is important to evaluate their variability in the normal heart. Several tracers were injected intravenously into anesthetized adult closed-chest rabbits, and time was allowed for equilibration in the heart. Tracer microspheres were injected into the left ventricular cavity at the apex for the measurement of regional flows, the chest was opened, another set of microspheres was injected, and the heart was frozen rapidly in situ with liquid nitrogen-cooled Freon-22. Each heart was divided into 72 pieces of less than 0.1 g weight, and the tracer content of each was determined by multichannel gamma-counting and the water content by desiccation. The regional myocardial flows were (closed chest) 0.62 +/- 0.16 ml.g-1.min-1 and (open chest) 0.63 +/- 0.37 ml.g-1.min-1. The volumes of distribution (ml/g) for the 432 pieces for six rabbits, given as mean +/- SD (% coefficient of variation), were as follows: for plasma, VP = 0.11 +/- 0.03 (26%); erythrocytes, VRBC = 0.041 +/- 0.015 (37%); vascular space, VV = 0.15 +/- 0.04 (26%); extracellular space, VECF = 0.33 +/- 0.05 (15%); interstitial space, VISF = 0.21 +/- 0.03 (15%); and water space, VW -0.79 +/- 0.022 (2.8%). Regional hematocrits were 77% +/- 9% of the large-vessel hematocrits.

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