Insulinopenia in impaired glucose tolerance preservation of insulin response to i.v. arginine and tolbutamide

1980 ◽  
Vol 17 (1) ◽  
pp. 1-7 ◽  
Author(s):  
John P. Monson ◽  
Leslie J. Borthwick ◽  
Gerassimos S. Spathis ◽  
Stephen R. Bloom
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Response

scholarly journals Interesting insulin response to oral glucose load in young Japanese subjects with impaired glucose tolerance

Diabetes Care ◽  
2000 ◽  
Vol 23 (5) ◽  
pp. 710-712 ◽  
Author(s):  
Y. Tanaka ◽  
Y. Atsumi ◽  
K. Matsuoka ◽  
T. Onuma ◽  
R. Kawamori
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Japanese Subjects

Reduced gastric inhibitory polypeptide but normal glucagon-like peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance

1997 ◽  
pp. 127-131 ◽  
Author(s):  
B Ahren ◽  
H Larsson ◽  
JJ Holst
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Postmenopausal Women ◽  
Plasma Levels ◽  
Insulin Response ◽  
Gastric Inhibitory Polypeptide ◽  
Oral Glucose ◽  
Glucose Ingestion ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

OBJECTIVE: The gastrointestinal hormones, gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), are both released from the gut after oral glucose ingestion and stimulate insulin secretion. This study examined the release of these hormones in subjects with impaired glucose tolerance (IGT), which precedes the development of non-insulin-dependent diabetes. DESIGN AND METHODS: Six postmenopausal women with IGT, aged 59 years, underwent a 75 g oral glucose tolerance test and plasma levels of GIP and GLP-1 were determined regularly during the following 2 h. The results were compared with those in seven age- and weight-matched women with normal glucose tolerance (NGT). RESULTS: Basal plasma levels of GIP and GLP-1 were not different between the groups. In response to the oral glucose ingestion, plasma levels of both GIP and GLP-1 increased in both groups. The plasma GIP increase after glucose ingestion was, however, reduced in women with IGT. Thus, the GIP response as determined as the area under the curve for the 60 min after oral glucose was 34.8 +/- 3.2 pmol/l per min in women with IGT versus 56.4 +/- 7.8 pmol/l per min in those with NGT (P = 0.021). In contrast, the GLP-1 response to oral glucose was not different between the groups. By definition, the glucose response to oral glucose was markedly increased in women with IGT, and the insulin response during the second hour after glucose ingestion was exaggerated. CONCLUSIONS: The GIP response to oral glucose is impaired in postmenopausal women with IGT, whereas the plasma GLP-1 response is not affected.

scholarly journals Early and late insulin response as predictors of NIDDM in Pima Indians with impaired glucose tolerance

Diabetologia ◽  
1995 ◽  
Vol 38 (2) ◽  
pp. 187-192 ◽  
Author(s):  
D. K. Nagi ◽  
W. C. Knowler ◽  
M. A. Charles ◽  
Q. Z. Liu ◽  
R. L. Hanson ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Response ◽  
Pima Indians

scholarly journals Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose

Diabetologia ◽  
1999 ◽  
Vol 42 (2) ◽  
pp. 177-180 ◽  
Author(s):  
J. B. Ruige ◽  
J. M. Dekker ◽  
G. Nijpels ◽  
C. Popp-Snijders ◽  
C. D. A. Stehouwer ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Response ◽  
Insulin Response To Glucose

scholarly journals Early and late insulin response as predictors of NIDDM in Pima Indians with impaired glucose tolerance

Diabetologia ◽  
1995 ◽  
Vol 38 (2) ◽  
pp. 187-192 ◽  
Author(s):  
D. K. Nagi ◽  
W. C. Knowler ◽  
P. H. Bennett ◽  
M. A. Charles ◽  
Q. Z. Liu ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Response ◽  
Pima Indians

scholarly journals Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance

2011 ◽  
Vol 107 (12) ◽  
pp. 1845-1849 ◽  
Author(s):  
Jennie Wickenberg ◽  
Sandra Lindstedt ◽  
Kerstin Berntorp ◽  
Jan Nilsson ◽  
Joanna Hlebowicz
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Plasma Glucose ◽  
Venous Blood ◽  
Insulin Response ◽  
Postprandial Glucose ◽  
Oral Glucose ◽  
Postprandial Plasma Glucose ◽  
Positive Effects ◽  
Federal Institute

Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanicum on postprandial concentrations of plasma glucose, insulin, glycaemic index (GI) and insulinaemic index (GII) in subjects with impaired glucose tolerance (IGT). A total of ten subjects with IGT were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with placebo or C. zeylanicum capsules. Finger-prick capillary blood samples were taken for glucose measurements and venous blood for insulin measurements, before and at 15, 30, 45, 60, 90, 120, 150 and 180 min after the start of the OGTT. The ingestion of 6 g C. zeylanicum had no significant effect on glucose level, insulin response, GI or GII. Ingestion of C. zeylanicum does not affect postprandial plasma glucose or insulin levels in human subjects. The Federal Institute for Risk Assessment in Europe has suggested the replacement of C. cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost.

HLA ANTIGENS IN A FAMILY WITH MATURITY-ONSET TYPE DIABETES MELLITUS

1978 ◽  
Vol 88 (2) ◽  
pp. 329-338 ◽  
Author(s):  
O. K. Faber ◽  
M. Thomsen ◽  
C. Binder ◽  
P. Platz ◽  
A. Svejgaard
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Plasma Insulin ◽  
Insulin Response ◽  
Hla Antigens ◽  
Oral Glucose ◽  
Onset Type ◽  
Hla Genotypes ◽  
Plasma Insulin Response

ABSTRACT In a family with maturity-onset type of diabetes mellitus inherited as a dominant, autosomal trait (MODY), the HLA genotypes were compared with the glucose tolerance and the plasma insulin response to oral glucose. In the members with impaired glucose tolerance, the plasma insulin response was of the insulino-tardic type, while those with normal or border-line glucose tolerance had a normal plasma insulin response. HLA tissue typing for A, B, C and D series antigens carried out in 19 of the members showed no association between specific HLA antigens and impaired glucose tolerance. Moreover, when analysing the segregation of the disease and the HLA characters, several recombinants between MODY and HLA would have to be postulated if the gene(s) for this form of diabetes mellitus should be closely linked to the HLA locus.

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