Total and ganglioside-bound sialic acid content of lymphocytes from non-insulin-dependent diabetic patients

1990 ◽  
Vol 27 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Mirjana Gavella ◽  
Vaskresenija Lipovac ◽  
Stjepan Crnek
Keyword(s):  
Sialic Acid ◽  
Acid Content ◽  
Diabetic Patients ◽  
Sialic Acid Content ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

LDL sialic acid content in type 2 diabetic patients

1997 ◽  
Vol 259 (1-2) ◽  
pp. 191-193 ◽  
Author(s):  
A. Ruelland ◽  
M.R. Durou ◽  
C. Letellier ◽  
E. Guehenneux ◽  
B. Legras ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Acid Content ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Sialic Acid Content ◽  
Type 2 Diabetic

Plasma and Urine Sialic Acid in Non-Insulin Dependent Diabetes Mellitus

1995 ◽  
Vol 32 (3) ◽  
pp. 303-306 ◽  
Author(s):  
Tomris Ozben ◽  
Sabahat Nacitarhan ◽  
Nese Tuncer
Keyword(s):  
Sialic Acid ◽  
Urinary Albumin Excretion ◽  
Albumin Excretion Rate ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Total Sialic Acid ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Urinary excretions of albumin, glycosaminoglycans (GAGS), total sialic acid (TSA), and lipid associated sialic acid (LASA) were measured in 78 non-insulin dependent diabetic patients (NIDDM) and 28 healthy subjects. TSA excretion was significantly higher in normoalbuminuric and microalbuminuric diabetic subjects than the control subjects and TSA excretion was correlated with urinary albumin excretion rate (AER). In normoalbuminuric diabetics, the duration of diabetes correlated significantly with both sialicaciduria and albuminuria. Although serum TSA levels were significantly higher in both diabetic groups than the control subjects, there was no correlation between serum and urinary TSA levels.

Decrease in erythrocyte glycophorin sialic acid content is associated with increased erythrocyte aggregation in human diabetes

1992 ◽  
Vol 82 (3) ◽  
pp. 309-313 ◽  
Author(s):  
Mark E. Rogers ◽  
Dean T. Williams ◽  
Ratnam Niththyananthan ◽  
Michael W. Rampling ◽  
Kirsten E. Heslop ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Erythrocyte Membrane ◽  
Normal Control ◽  
Acid Content ◽  
Erythrocyte Aggregation ◽  
Diabetic Patients ◽  
Membrane Glycoproteins ◽  
Sialic Acid Content ◽  
Control Subjects ◽  
Suspension Viscosity

1. Sialic acid moieties of erythrocyte membrane glycoproteins are the principal determinants of the negative charge on the cell surface. The resultant electrostatic repulsion between the cells reduces erythrocyte aggregation and hence the low shear rate viscosity and yield stress of blood. 2. Using g.c.–m.s., a decrease in sialic acid content has been observed in the major erythrocyte membrane glycoprotein, glycophorin A, obtained from nine diabetic patients compared with that from seven normal control subjects [median (range): 3.30 (0.01–11.90) versus 18.60 (3.20–32.60) μg/100 μg of protein, P<0.02]. 3. Erythrocyte aggregation, measured by viscometry as the ratio of suspension viscosity to supernatant viscosity (Ls/S) in fibrinogen solution, was increased in ten diabetic patients compared with ten normal control subjects (mean ± sem, 37.6 ± 1.3 versus 33.8 ± 0.6, P<0.02). 4. In the patients in whom both viscometry and carbohydrate analysis were performed, the decrease in erythrocyte glycophorin sialylation and the increase in erythrocyte aggregation in fibrinogen solution were related statistically(LS/S correlated negatively with glycophorin sialic acid content, r = 0.73, P <0.05). 5. Decreased glycophorin sialylation provides an explanation at the molecular level for increased erythrocyte aggregation and it may be important in the pathogenesis of vascular disease in diabetes.

scholarly journals The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia

2019 ◽  
Vol 11 (1) ◽  
pp. 19-26
Author(s):  
Sedigheh Shahvali ◽  
Armita Shahesmaeili ◽  
Mojgan Sanjari ◽  
Somayyeh Karami-Mohajeri
Keyword(s):  
Oxidative Stress ◽  
Sialic Acid ◽  
Acid Content ◽  
Diabetic Patients ◽  
Sialic Acid Content

129: Sialic Acid Content of Urinary TAMM-Horsfall Protein is Reduced in Interstitial Cystitis Patients

2007 ◽  
Vol 177 (4S) ◽  
pp. 44-45
Author(s):  
C. Lowell Parsons ◽  
Mahadevan Rajasekaran ◽  
Marianne Chenoweth ◽  
Paul Stein
Keyword(s):  
Sialic Acid ◽  
Interstitial Cystitis ◽  
Acid Content ◽  
Sialic Acid Content

Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients

Diabetes ◽  
1985 ◽  
Vol 34 (11) ◽  
pp. 1127-1133 ◽  
Author(s):  
R. K. Mayfield ◽  
P. V. Halushka ◽  
H. J. Wohltmann ◽  
M. Lopes-Virella ◽  
J. K. Chambers ◽  
...  
Keyword(s):  
Platelet Function ◽  
Insulin Infusion ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Continuous Insulin Infusion
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