Effects of lithium on potassium homeostasis in the guinea pig olfactory cortex slice

1982 ◽  
Vol 394 (S1) ◽  
pp. R47-R47
Author(s):  
P. Grafe ◽  
M. M. Reddy ◽  
G. ten Bruggencate
Keyword(s):  
Guinea Pig ◽  
Olfactory Cortex ◽  
Potassium Homeostasis ◽  
Cortex Slice

scholarly journals Cellular mechanisms of potassium homeostasis in the mammalian nervous system

1987 ◽  
Vol 65 (5) ◽  
pp. 1038-1042 ◽  
Author(s):  
P. Grafe ◽  
K. Ballanyi
Keyword(s):  
Guinea Pig ◽  
Glial Cells ◽  
Sympathetic Ganglia ◽  
Olfactory Cortex ◽  
Lateral Olfactory Tract ◽  
Cellular Mechanisms ◽  
Potassium Homeostasis ◽  
Ion Sensitive Microelectrodes ◽  
Sympathetic Neurones ◽  
Intracellular Activities

Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl− (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex. In sympathetic neurones, carbachol and γ-aminobutyric acid (GABA) produced a reversible decrease of aKi. The decrease of aKi during carbachol was accompanied by a rise of aNai, whereas in the presence of GABA decreases of aKi and aCli were seen. The reuptake of K+ released during the action of carbachol was completely blocked by ouabain, whereas furosemide inhibited the aKi recovery after the action of GABA. In glial cells, in contrast to the observations in the sympathetic neurones, aKi and aCli increased, whereas aNai decreased when neuronal activity was enhanced by repetitive stimulation of the lateral olfactory tract. It was found that barium ions and ouabain strongly reduced the activity-related rise of intraglial aKi in slices of guinea-pig olfactory cortex. These data show that mammalian neurones as well as glial cells possess several K+ uptake mechanisms that contribute to potassium homeostasis. Ouabain, furosemide, and Ba2+ are useful pharmacological tools to separate these mechanisms.

scholarly journals Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice

1982 ◽  
Vol 241 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Martin Galvan ◽  
Peter Grafe ◽  
Gerrit Ten Bruggencate
Keyword(s):  
Guinea Pig ◽  
Olfactory Cortex ◽  
Cortex Slice

Intracellularly-recorded effects of glutamate and aspartate on neurones in the guinea-pig olfactory cortex slice

1980 ◽  
Vol 195 (2) ◽  
pp. 403-420 ◽  
Author(s):  
A. Constanti ◽  
J.D. Connor ◽  
M. Galvan ◽  
A. Nistri
Keyword(s):  
Guinea Pig ◽  
Olfactory Cortex ◽  
Cortex Slice
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