scholarly journals Clonal rearrangements of T-cell receptor and immunoglobul in genes as sensitive marker for bone marrow involvement in non-Hodgkin's lymphoma

1986 ◽  
Vol 111 (S1) ◽  
pp. S104-S104
Author(s):  
M. Krönke ◽  
G. Krieger ◽  
M. Kneba ◽  
G. A. Nagel ◽  
K. Pfizenmaier
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
T Cell Receptor ◽  
Hodgkin’S Lymphoma ◽  
Bone Marrow Involvement ◽  
Cell Receptor ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Sensitive Marker

scholarly journals Non-Hodgkin's lymphoma containing both B and T cell clones

Blood ◽  
1987 ◽  
Vol 70 (1) ◽  
pp. 287-292 ◽  
Author(s):  
E Hu ◽  
LM Weiss ◽  
R Warnke ◽  
J Sklar
Keyword(s):  
T Cell ◽  
Hodgkin’S Lymphoma ◽  
Cell Clone ◽  
Tumor Development ◽  
Cell Receptor ◽  
Hodgkin's Lymphoma ◽  
T Cell Clones ◽  
Non Hodgkin’S Lymphoma ◽  
Cell Clones ◽  
Non Hodgkin's Lymphoma

Abstract We describe a patient in whom two lymph node biopsies removed 18 months apart disclosed histologic and immunophenotypic evidence of a non- Hodgkin's lymphoma containing neoplastic lymphocytes of both B and T type. Analyses of immunoglobulin and T cell receptor genes confirmed the presence of separate B and T cell clones. In addition, immunogenotyping revealed the possibility of a second B cell clone within the patient's tumor. Development of a multiclonal lymphoma in this patient may relate to the carcinogenic effects of chemotherapy or to a predisposition for neoplastic transformation of lymphocytes due to a previously diagnosed autoimmune condition. Another possible explanation is that the lymphoma implies the existence in this patient of a transformed lymphocyte-committed stem cell that is capable of generating both B and T lineage clones.

T Cell γ Chain Gene Rearrangement without T Cell Receptor β Chain Gene Rearrangement in Two Cases of Non-Hodgkin’s Lymphoma

1987 ◽  
Vol 77 (3) ◽  
pp. 172-176 ◽  
Author(s):  
Masao Matsuoka ◽  
Norio Asou ◽  
Toshio Hattori ◽  
Takashi Matsuo ◽  
Hiromichí Nishimura ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Hodgkin’S Lymphoma ◽  
Gene Rearrangement ◽  
Cell Receptor ◽  
Hodgkin's Lymphoma ◽  
Chain Gene ◽  
Non Hodgkin's Lymphoma ◽  
Chain Gene Rearrangement ◽  
Β Chain
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