scholarly journals EGF binding sites are present in non-small cell lung cancer cell lines and the urinary bladder carcinoma cell line 5637

1986 ◽  
Vol 111 (S1) ◽  
pp. S64-S64
Author(s):  
M. Häder ◽  
M. Rotsch ◽  
G. Bepler ◽  
P. Kiefer ◽  
K. Havemann
Keyword(s):  
Lung Cancer ◽  
Urinary Bladder ◽  
Bladder Carcinoma ◽  
Binding Sites ◽  
Carcinoma Cell ◽  
Small Cell ◽  
Urinary Bladder Carcinoma ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Bladder Carcinoma Cell Line

Establishment and characterization of a human urinary bladder carcinoma cell line (TSGH-8301)

1988 ◽  
Vol 37 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Ming-Yang Yeh ◽  
Dah-Shyong Yü ◽  
Shan-Chun Chen ◽  
Ming-Shan Lin ◽  
Sun-Yran Chang ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Line ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Urinary Bladder Carcinoma ◽  
Human Urinary Bladder ◽  
Bladder Carcinoma Cell Line

Are BCG Effects against Urinary Bladder Carcinoma Cell Line T24 Correlated with Apoptosis in vitro?

1997 ◽  
Vol 59 (3) ◽  
pp. 142-148 ◽  
Author(s):  
Atsushi Sasaki ◽  
Seiji Kudoh ◽  
Kazuyuki Mori ◽  
Nobuyoshi Takahashi ◽  
Tadashi Suzuki
Keyword(s):  
Urinary Bladder ◽  
Cell Line ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Urinary Bladder Carcinoma ◽  
Bladder Carcinoma Cell Line

scholarly journals Staphylococcus saprophyticusATCC 15305 is internalized into human urinary bladder carcinoma cell line 5637

2008 ◽  
Vol 285 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Florian Szabados ◽  
Britta Kleine ◽  
Agnes Anders ◽  
Martin Kaase ◽  
Türkân Sakınç ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Line ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Urinary Bladder Carcinoma ◽  
Human Urinary Bladder ◽  
Bladder Carcinoma Cell Line

Establishment and Characterization of a Human Urinary Bladder Carcinoma Cell Line (TSGH-8301)

1988 ◽  
Vol 140 (5 Part 1) ◽  
pp. 1075-1075
Author(s):  
M.-Y. Yeh ◽  
D.-S. Yü ◽  
S.-C. Chen ◽  
M.-S. Lin ◽  
S.-Y. Chang ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Line ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Urinary Bladder Carcinoma ◽  
Human Urinary Bladder ◽  
Bladder Carcinoma Cell Line

scholarly journals Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70S6K signaling pathway

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sutthaorn Pothongsrisit ◽  
Kuntarat Arunrungvichian ◽  
Yoshihiro Hayakawa ◽  
Boonchoo Sritularak ◽  
Supachoke Mangmool ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Migration ◽  
Protein Kinase ◽  
Small Cell Lung Cancer ◽  
Cancer Metastasis ◽  
Small Cell ◽  
Migration And Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Cell Metastasis

AbstractCancer metastasis is a major cause of the high mortality rate in lung cancer patients. The cytoskeletal rearrangement and degradation of extracellular matrix are required to facilitate cell migration and invasion and the suppression of these behaviors is an intriguing approach to minimize cancer metastasis. Even though Erianthridin (ETD), a phenolic compound isolated from the Thai orchid Dendrobium formosum exhibits various biological activities, the molecular mechanism of ETD for anti-cancer activity is unclear. In this study, we found that noncytotoxic concentrations of ETD (≤ 50 μM) were able to significantly inhibit cell migration and invasion via disruption of actin stress fibers and lamellipodia formation. The expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 was markedly downregulated in a dose-dependent manner after ETD treatment. Mechanistic studies revealed that protein kinase B (Akt) and its downstream effectors mammalian target of rapamycin (mTOR) and p70 S6 kinase (p70S6K) were strongly attenuated. An in silico study further demonstrated that ETD binds to the protein kinase domain of Akt with both hydrogen bonding and van der Waals interactions. In addition, an in vivo tail vein injection metastasis study demonstrated a significant effect of ETD on the suppression of lung cancer cell metastasis. This study provides preclinical information regarding ETD, which exhibits promising antimetastatic activity against non-small-cell lung cancer through Akt/mTOR/p70S6K-induced actin reorganization and MMPs expression.

Sign in / Sign up

Export Citation Format

Share Document