Kupffer cell function in chronic liver injury and after partial hepatectomy

1994 ◽  
Vol 194 (1) ◽  
pp. 237-246 ◽  
Author(s):  
Keisuke Hamazaki ◽  
Shizo Sato ◽  
Masayuki Yunoki ◽  
Taku Noda ◽  
Luis Fernando Moreira ◽  
...  
Keyword(s):  
Liver Injury ◽  
Partial Hepatectomy ◽  
Kupffer Cell ◽  
Cell Function ◽  
Chronic Liver ◽  
Chronic Liver Injury

Attenuation of Kupffer Cell Function in Acute on Chronic Liver Injury Enhanced Engraftment of Transplanted Hepatocytes

2007 ◽  
Vol 31 (6) ◽  
pp. 1272-1279 ◽  
Author(s):  
Ray-Hwang Yuan ◽  
Hui-Ling Chen ◽  
Huey-Ling Chen ◽  
Ming-Kung Hsu ◽  
Po-Huang Lee ◽  
...  
Keyword(s):  
Liver Injury ◽  
Kupffer Cell ◽  
Cell Function ◽  
Chronic Liver ◽  
Chronic Liver Injury

scholarly journals Mechanisms of platelet-mediated liver regeneration

Blood ◽  
2016 ◽  
Vol 128 (5) ◽  
pp. 625-629 ◽  
Author(s):  
Ton Lisman ◽  
Robert J. Porte
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Therapeutic Strategies ◽  
Chronic Liver ◽  
Chronic Liver Injury ◽  
Multiple Functions ◽  
Definitive Evidence

Abstract Platelets have multiple functions beyond their roles in thrombosis and hemostasis. Platelets support liver regeneration, which is required after partial hepatectomy and acute or chronic liver injury. Although it is widely assumed that platelets stimulate liver regeneration by local excretion of mitogens stored within platelet granules, definitive evidence for this is lacking, and alternative mechanisms deserve consideration. In-depth knowledge of mechanisms of platelet-mediated liver regeneration may lead to new therapeutic strategies to treat patients with failing regenerative responses.

scholarly journals Lymphotoxin-β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury

Hepatology ◽  
2008 ◽  
Vol 49 (1) ◽  
pp. 227-239 ◽  
Author(s):  
Richard G. Ruddell ◽  
Belinda Knight ◽  
Janina E. E. Tirnitz-Parker ◽  
Barbara Akhurst ◽  
Lesa Summerville ◽  
...  
Keyword(s):  
Wound Healing ◽  
Liver Injury ◽  
Hepatic Stellate Cell ◽  
Murine Model ◽  
Cell Function ◽  
Stellate Cell ◽  
Chronic Liver ◽  
Receptor Signaling ◽  
Chronic Liver Injury ◽  
Β Receptor

scholarly journals Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

2017 ◽  
Vol 2017 ◽  
pp. 1-22 ◽  
Author(s):  
Ioannis G. Papanikolaou ◽  
Charalambos Katselis ◽  
Konstantinos Apostolou ◽  
Themistoklis Feretis ◽  
Maria Lymperi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Failure ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Chronic Liver ◽  
Review Of The Literature ◽  
Chronic Liver Injury ◽  
Stem Cells Transplantation

Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury. A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database. The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”. All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity. A total of 41 articles were identified for potential inclusion and reviewed in detail. After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review. MSCs transplantation promoted LG and improved liver function. Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms. MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.

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