Value of C-reactive protein in reflecting the magnitude of complement activation in children undergoing open heart surgery

1990 ◽  
Vol 16 (2) ◽  
pp. 128-132 ◽  
Author(s):  
M. Aronen ◽  
M. Leijala ◽  
S. Meri
Keyword(s):  
Complement Activation ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Complement (C3, C4) and C-reactive Protein Responses to Cardiopulmonary Bypass and Protamine Administration

1993 ◽  
Vol 21 (1) ◽  
pp. 50-55 ◽  
Author(s):  
M. Tulunay ◽  
S. Demiralp ◽  
S. Tastan ◽  
H. Akalin ◽  
U. Ozyurda ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Complement System ◽  
Complement Activation ◽  
Heart Surgery ◽  
Tissue Injury ◽  
Open Heart Surgery ◽  
Complement C3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Protamine Administration

Complement activation has been deemed responsible for the damaging effects of cardiopulmonary bypass (CPB) in patients undergoing open heart surgery. We studied C3, C4 and C-reactive protein (CRP) in 22 patients undergoing CPB. In Group 1 (11 patients), protamine was given intravenously and in Group 2 (11 patients), via the aortic root after CPB. Significant decreases were observed in C3 and C4 during CPB in both groups indicating complement activation primarily by the classic pathway. Protamine did not lead to further activation of the complement system. In both groups, C3 levels gradually returned toward baseline within 24 hours but C4 levels were still lower than baseline 24 hours postoperatively. CPB and protamine administration did not cause any significant changes in CRP levels, but CRP increased abruptly 24 hours after operation. Although activation of complement system during CPB is expected to invoke an acute phase response, we conclude that this period is not long enough to induce an increased production of CRP in response to tissue injury or inflammation.

scholarly journals A novel case of impaired C-reactive protein response following open-heart surgery: a case report and review of the literature

2021 ◽  
Author(s):  
Erik Wilhelm Vinnes ◽  
Paul Kjetel Soldal Lillemoen ◽  
Robert Matongo Persson ◽  
Klaus Meyer ◽  
Rune Haaverstad ◽  
...  
Keyword(s):  
Case Report ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Review Of The Literature ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Protein Response

scholarly journals Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Franco Lerzo ◽  
Giuseppe Peri ◽  
Andrea Doni ◽  
Paola Bocca ◽  
Fabio Morandi ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Heart Surgery ◽  
Interleukin 1 ◽  
Open Heart Surgery ◽  
Open Heart ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Inflammatory Parameter ◽  
Improve Clinical Outcome

Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the study. Fourteen received dexamethasone (1st dose 1.5 mg/Kg i.v. or i.m. the evening before surgery; 2nd dose 1.5 mg/kg i.v. before starting bypass) and fifteen children served as control. Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times. PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (−D) subjects, but were significantly higher in +D than −D patients. CRP levels significantly increased both in +D and −D patients in the postoperative days, with values significantly higher in −D than +D patients. Fibrinogen and PTT values were significantly higher in −D than +D patients in the 1st postoperative day. IL-1RII plasma levels increased in the postoperative period in both groups. Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome.

Neutrophil Lactoferrin Release During Open Heart Surgery Is Unrelated to Complement Activation

ASAIO Journal ◽  
1994 ◽  
Vol 40 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Kaushik A. Shastri ◽  
Gerald L. Logue ◽  
Mont P. Stern ◽  
Syed Raza ◽  
Brian M. OʼConnor ◽  
...  
Keyword(s):  
Complement Activation ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

Neutrophil Lactoferrin Release During Open Heart Surgery Is Unrelated to Complement Activation

ASAIO Journal ◽  
1994 ◽  
Vol 40 (1) ◽  
pp. 56-61
Author(s):  
KAUSHIK A. SHASTRI ◽  
GERLAD L. LOGUE ◽  
MONT P. STERN ◽  
SYED RAZA ◽  
BRIAN M. OʼCONNOR ◽  
...  
Keyword(s):  
Complement Activation ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

Comparison of the effects of centrifugal versus roller pump on the immune response in open-heart surgery

Perfusion ◽  
1995 ◽  
Vol 10 (4) ◽  
pp. 249-256 ◽  
Author(s):  
J. Perttilä ◽  
M. Salo ◽  
O. Peltola
Keyword(s):  
Immune Responses ◽  
Centrifugal Pump ◽  
Coronary Artery Bypass Surgery ◽  
Heart Surgery ◽  
Artery Bypass ◽  
Open Heart Surgery ◽  
Pokeweed Mitogen ◽  
C Reactive Protein ◽  
Roller Pump ◽  
Reactive Protein

We compared the effects of a centrifugal pump with those of a roller pump on immune responses in 26 coronary artery bypass surgery patients during cardiopulmonary bypass (CPB). The patients were randomly allocated into a (Biomedicus) centrifugal pump group and a (Stöckert) twin roller pump group. Leucocyte and differential counts; percentages of lymphocyte subpopulations (CD3-, CD4-, CD8-, CD16-, CD20- and CD25-positive lymphocytes) and monocytes (CD14); phytohaemagglutinin-, concanavalin A-, and pokeweed mitogen-induced and unstimulated proliferation of separated lymphocytes; unstimulated and pokeweed mitogen-stimulated production of IgG, IgM, or IgA; and plasma fibronectin, C-reactive protein and serum albumin concentrations were measured preoperatively, immediately before CPB, immediately before aortic declamping and on the first postoperative morning. Significant changes were seen in these variables, but no differences occurred between the groups.

scholarly journals Neutrophil Lactoferrin Release During Open Heart Surgery Is Unrelated to Complement Activation

ASAIO Journal ◽  
1994 ◽  
Vol 40 (SUPPLEMENT 1) ◽  
pp. 56???61
Author(s):  
KAUSHIK A. SHASTRI ◽  
GERALD L. LOGUE ◽  
MONT P. STERN ◽  
SYED RAZA ◽  
BRIAN M. O??CONNOR ◽  
...  
Keyword(s):  
Complement Activation ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart
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