The heparin-induced thrombocytopenia and thrombosis syndrome: Treatment with intraarterial urokinase and systemic platelet aggregation inhibitors

1996 ◽  
Vol 19 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Kenneth D. Murphy ◽  
Gerard McCrohan ◽  
Deborah A. DeMarta ◽  
Nitin B. Shirodkar ◽  
Oun J. Kwon ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Platelet Aggregation Inhibitors ◽  
Heparin Induced Thrombocytopenia ◽  
Aggregation Inhibitors

New Platelet Aggregation Inhibitors

1997 ◽  
Vol 17 (01) ◽  
pp. 43-48 ◽  
Author(s):  
R. Verhaeghe ◽  
J. Vermylen
Keyword(s):  
Platelet Aggregation ◽  
Platelet Aggregation Inhibitors ◽  
Aggregation Inhibitors

scholarly journals Platelet Aggregation Inhibitors in a Bhutanese Medicinal Plant, Shug Chher.

1993 ◽  
Vol 41 (9) ◽  
pp. 1604-1607 ◽  
Author(s):  
Kiyomi KAGAWA ◽  
Katsuya TOKURA ◽  
Kiyohisa UCHIDA ◽  
Hisato KAKUSHI ◽  
Tsutomu SHIKE ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Medicinal Plant ◽  
Platelet Aggregation Inhibitors ◽  
Aggregation Inhibitors

scholarly journals ACE and platelet aggregation inhibitors from Tamarix hohenackeri Bunge (host plant of Herba Cistanches) growing in Xinjiang

2014 ◽  
Vol 10 (38) ◽  
pp. 111 ◽  
Author(s):  
Jing Liao ◽  
Yingzhan Tang ◽  
Chengyu Tan ◽  
Hui Ni ◽  
Xueqin Wu ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Host Plant ◽  
Platelet Aggregation Inhibitors ◽  
Aggregation Inhibitors

scholarly journals Comparative Study on the Effect of Carbenicillin, Inhibitors of Platelet Function and Heparin on Experimental Thrombus Formation

1977 ◽  
Author(s):  
R. Zimmermann ◽  
K. Andrassy ◽  
C. Zeltsch ◽  
D. Lange ◽  
F. Hof
Keyword(s):  
Platelet Aggregation ◽  
Bleeding Time ◽  
Thrombus Formation ◽  
Platelet Aggregation Inhibitors ◽  
Venous System ◽  
Arterial System ◽  
Antithrombotic Activity ◽  
Lower Extent ◽  
Aggregation Inhibitors ◽  
Blood Elements

Previous studies documented an impairment of haemostasis by synthetic penicillins (Thromb. Haem. 34: 115, 1976) and penicillin (Lancet II : 1039, 1976). Therefore the antithrombotic activity of synthetic penicillin. (carbenicillin)(C) was compared with that of aspirin (ASA), dipyridamole (DIPY) and heparin in 150 rabbits. Thrombus formation was induced by standardized endothelial lesions. The dose of C was adjusted to a 4.2 fold prolongation of bleeding time, similar to that seen in clinical patients. Analysis and composition of thrombi was done by measurement of incorporation of labeled blood elements (51cr labeled platelets, 125J-fibrinogen and 59Fe labeled red cells). The ‘specific thrombus/blood ratio’ with values of 19.1 and 50.9 (51cr) in venous and arterial thrombi evidenced the significance of platelets in this model. In the venous system C reduced formation of thrombi by 43%, ASA by 34%, ASA and DIPY by 55% and heparin by 90%. In the arterial system C inhibited thrombus formation by 89%, ASA by 15%, ASA and DIPY by 46% and heparin by 60%. It is concluded, that C effectively prevents thrombus formation in the arterial system and to lower extent in the venous system. The results prove the importance of platelets in arterial thrombogenesis and the efficacy of platelet aggregation inhibitors in preventing thrombi in the arterial system. In comparison with other known antiplatelet drugs it seems, that C is the most effective platelet aggregation inhibitor to date.

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