n-3 fatty acids and the risk of sudden cardiac death assessed by 24-hour heart rate variability

Lipids ◽  
1999 ◽  
Vol 34 (S1) ◽  
pp. S197-S197 ◽  
Author(s):  
J. H. Christensen ◽  
J. Dyerberg ◽  
E. B. Schmidt
Keyword(s):  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Sudden Cardiac Death ◽  
Cardiac Death

scholarly journals Effects of Marine n-3 Polyunsaturated Fatty Acids on Heart Rate Variability and Heart Rate in Patients on Chronic Dialysis: A Randomized Controlled Trial

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1313 ◽  
Author(s):  
Jesper Rantanen ◽  
Sam Riahi ◽  
Martin Johansen ◽  
Erik Schmidt ◽  
Jeppe Christensen
Keyword(s):  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Sudden Cardiac Death ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Death ◽  
Controlled Trial ◽  
Chronic Dialysis ◽  
Dialysis Vintage ◽  
The Mean

Marine n-3 polyunsaturated fatty acids (PUFA) may improve autonomic dysfunction, as indicated by an increase in heart rate variability (HRV) and reduce the risk of sudden cardiac death. Hence, the aim of this study was to investigate the effects of marine n-3 PUFA on 24-h HRV in patients on chronic dialysis, who have a high risk of sudden cardiac death. Between June 2014 and March 2016, 112 patients on chronic dialysis from Denmark were allocated to a daily supplement of 2 g marine n-3 PUFA or control for three months in a randomized, double-blinded, controlled trial. A 48-h Holter monitoring was performed and mean 24-h HRV indices for the two days were available in 85 patients. The mean age was 62.3 years (SD: 14.3) and median dialysis vintage was 1.7 years (IQR: 0.5, 6.4). Within-group and between-group changes in outcome were evaluated by a paired and two sample t-test, respectively. Marine n-3 PUFA did not change the primary endpoint SDNN (SD of all RR-intervals) reflecting overall HRV, but other HRV indices increased and the mean RR-interval increased significantly, corresponding to a decrease in heart rate by 2.5 beats per minute (p = 0.04). In conclusion, marine n-3 PUFA did not change SDNN, but the mean heart rate was significantly reduced and changes in other HRV-indices were also observed, indicating an increase in vagal modulation that might be protective against malignant ventricular arrhythmias.

n−3 fatty acids, heart rate variability, and sudden cardiac death

Lipids ◽  
2001 ◽  
Vol 36 (S1) ◽  
pp. S115-S118 ◽  
Author(s):  
Jeppe Hagstrup Christensen ◽  
Erik Berg Schmidt
Keyword(s):  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Sudden Cardiac Death ◽  
Cardiac Death

scholarly journals Heart Rate Variability and Long Chain n-3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2453
Author(s):  
Ana M Pinto ◽  
Helen L MacLaughlin ◽  
Wendy L Hall
Keyword(s):  
Chronic Kidney Disease ◽  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Kidney Disease ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Death ◽  
Cross Sectional ◽  
Ckd Stage ◽  
Long Chain

Low heart rate variability (HRV) is independently associated with increased risk of sudden cardiac death (SCD) and all cardiac death in haemodialysis patients. Long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) may exert anti-arrhythmic effects. This study aimed to investigate relationships between dialysis, sleep and 24 h HRV and LC n-3 PUFA status in patients who have recently commenced haemodialysis. A cross-sectional study was conducted in adults aged 40–80 with chronic kidney disease (CKD) stage 5 (n = 45, mean age 58, SD 9, 20 females and 25 males, 39% with type 2 diabetes). Pre-dialysis blood samples were taken to measure erythrocyte and plasma fatty acid composition (wt % fatty acids). Mean erythrocyte omega-3 index was not associated with HRV following adjustment for age, BMI and use of β-blocker medication. Higher ratios of erythrocyte eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) were associated with lower 24 h vagally-mediated beat-to-beat HRV parameters. Higher plasma EPA and docosapentaenoic acid (DPAn-3) were also associated with lower sleep-time and 24 h beat-to-beat variability. In contrast, higher plasma EPA was significantly related to higher overall and longer phase components of 24 h HRV. Further investigation is required to investigate whether patients commencing haemodialysis may have compromised conversion of EPA to DHA, which may impair vagally-mediated regulation of cardiac autonomic function, increasing risk of SCD.

scholarly journals Prediction of Sudden Cardiac Death Risk with a Support Vector Machine Based on Heart Rate Variability and Heartprint Indices

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5483
Author(s):  
Marisol Martinez-Alanis ◽  
Erik Bojorges-Valdez ◽  
Niels Wessel ◽  
Claudia Lerma
Keyword(s):  
Heart Rate ◽  
Support Vector Machine ◽  
Heart Rate Variability ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Area Under The Curve ◽  
Premature Ventricular Complex ◽  
Support Vector ◽  
Auc Value ◽  
Sudden Cardiac Death Risk

Most methods for sudden cardiac death (SCD) prediction require long-term (24 h) electrocardiogram recordings to measure heart rate variability (HRV) indices or premature ventricular complex indices (with the heartprint method). This work aimed to identify the best combinations of HRV and heartprint indices for predicting SCD based on short-term recordings (1000 heartbeats) through a support vector machine (SVM). Eleven HRV indices and five heartprint indices were measured in 135 pairs of recordings (one before an SCD episode and another without SCD as control). SVMs (defined with a radial basis function kernel with hyperparameter optimization) were trained with this dataset to identify the 13 best combinations of indices systematically. Through 10-fold cross-validation, the best area under the curve (AUC) value as a function of γ (gamma) and cost was identified. The predictive value of the identified combinations had AUCs between 0.80 and 0.86 and accuracies between 80 and 86%. Further SVM performance tests on a different dataset of 68 recordings (33 before SCD and 35 as control) showed AUC = 0.68 and accuracy = 67% for the best combination. The developed SVM may be useful for preventing imminent SCD through early warning based on electrocardiogram (ECG) or heart rate monitoring.

Novel spectral indexes of heart rate variability as predictors of sudden and non‐sudden cardiac death after an acute myocardial infarction

2007 ◽  
Vol 39 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Antti M. Kiviniemi ◽  
Mikko P. Tulppo ◽  
Dan Wichterle ◽  
Arto J. Hautala ◽  
Suvi Tiinanen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Sudden Cardiac Death ◽  
Cardiac Death
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