Hyperglycemia inhibits liver fatty acid oxidation and increases triacylglycerol secretion in humans

Lipids ◽  
1999 ◽  
Vol 34 (S1) ◽  
pp. S95-S95
Author(s):  
S. Sidossis ◽  
B. Mittendorfer ◽  
E. Walser ◽  
D. Chinkes ◽  
R. Wolfe
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Liver Fatty Acid

scholarly journals ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

Cell Reports ◽  
2017 ◽  
Vol 19 (9) ◽  
pp. 1794-1806 ◽  
Author(s):  
Diane DeZwaan-McCabe ◽  
Ryan D. Sheldon ◽  
Michelle C. Gorecki ◽  
Deng-Fu Guo ◽  
Erica R. Gansemer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Er Stress ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Liver Fatty Acid ◽  
Liver And Kidney

Hormonal and nutritional control of liver fatty acid oxidation and ketogenesis during development

1995 ◽  
Vol 23 (3) ◽  
pp. 500-506 ◽  
Author(s):  
C. Prip-Buus ◽  
S. Thumelin ◽  
F. Chatelain ◽  
J.-P. Pegorier ◽  
J. Girard
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Liver Fatty Acid

Evaluation of Liver Fatty Acid Oxidation in the Leptin-Deficient Obese Mouse

2002 ◽  
Vol 75 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Amy E. Brix ◽  
Ada Elgavish ◽  
Tim R. Nagy ◽  
Barbara A. Gower ◽  
William J. Rhead ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Obese Mouse ◽  
Acid Oxidation ◽  
Liver Fatty Acid

scholarly journals Vitamin A deficiency modifies lipid metabolism in rat liver

2007 ◽  
Vol 97 (2) ◽  
pp. 263-272 ◽  
Author(s):  
Liliana B. Oliveros ◽  
María A. Domeniconi ◽  
Verónica A. Vega ◽  
Laura V. Gatica ◽  
Ana M. Brigada ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Vitamin A ◽  
Mrna Expression ◽  
Fatty Acid Oxidation ◽  
Vitamin A Deficiency ◽  
Total Phospholipid ◽  
Male Rats ◽  
Acid Oxidation ◽  
Liver Fatty Acid ◽  
Cpt I

Liver fatty acid metabolism of male rats fed on a vitamin A-deficient diet for 3 months from 21 d of age was evaluated. Vitamin A restriction produced subclinical plasma and negligible liver retinol concentrations, compared with the control group receiving the same diet with 4000 IU vitamin A (8 mg retinol as retinyl palmitate)/kg diet. Vitamin A deficiency induced a hypolipidaemic effect by decreasing serum triacylglycerol, cholesterol and HDL-cholesterol levels. The decrease of liver total phospholipid was associated with low phosphatidylcholine synthesis observed by lower [14C]choline incorporation into phosphatidylcholine, compared with control. Also, liver fatty acid synthesis decreased, as was indicated by activity and mRNA expression of acetyl-CoA carboxylase (ACC), and incorporation of [14C]acetate into saponified lipids. A decrease of the PPARα mRNA expression was observed. Liver mitochondria of vitamin A-deficient rats showed a lower total phospholipid concentration coinciding with a decrease of the cardiolipin proportion, without changes in the other phospholipid fractions determined. The mitochondria fatty acid oxidation increased by 30 % of the control value and it was attributed to a high activity and mRNA expression of carnitine palmitoyltransferase-I (CPT-I). An increase in serum β-hydroxybutyrate levels was observed in vitamin A-deficient rats. Vitamin A deficiency alters the mitochondria lipid composition and also enhances fatty acid oxidation by modifiying the production of malonyl-CoA, the endogenous inhibitor of CPT-I, due to decreased activity of liver ACC. The incorporation of vitamin A into the diet of vitamin A-deficient rats reverted all the changes observed.

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