Octacalcium phosphate formationin vitro: Implications for bone formation

1985 ◽  
Vol 37 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Pei-Tak Cheng
Keyword(s):  
Bone Formation ◽  
Octacalcium Phosphate

scholarly journals Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4391
Author(s):  
Yoona Jung ◽  
Won-Hyeon Kim ◽  
Sung-Ho Lee ◽  
Kyung Won Ju ◽  
Eun-Hee Jang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Octacalcium Phosphate ◽  
Autogenous Bone ◽  
Graft Material ◽  
Calvarial Defect ◽  
Bone Area ◽  
Defect Model ◽  
Bone Graft Material ◽  
Experimental Group

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

Alginate/octacalcium phosphate composites enhance bone formation in critical-sized mouse calvaria defects

2010 ◽  
pp. 308-310
Author(s):  
Takeshi Fuji ◽  
Takahisa Anada ◽  
Yoshitomo Honda ◽  
Yukari Shiwaku ◽  
Keiichi Sasaki ◽  
...  
Keyword(s):  
Bone Formation ◽  
Octacalcium Phosphate ◽  
Mouse Calvaria ◽  
Enhance Bone Formation

Bioactivity and effect of bone formation for octacalcium phosphate ceramics

2020 ◽  
pp. 85-119
Author(s):  
Vladimir S. Komlev ◽  
Ilya I. Bozo ◽  
Roman V. Deev ◽  
Alex N. Gurin
Keyword(s):  
Bone Formation ◽  
Octacalcium Phosphate

Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite

Biomaterials ◽  
2006 ◽  
Vol 27 (13) ◽  
pp. 2671-2681 ◽  
Author(s):  
O SUZUKI ◽  
S KAMAKURA ◽  
T KATAGIRI ◽  
M NAKAMURA ◽  
B ZHAO ◽  
...  
Keyword(s):  
Bone Formation ◽  
Octacalcium Phosphate

scholarly journals Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone

2021 ◽  
Author(s):  
Jooseong Kim ◽  
Sukyoung Kim ◽  
In-Hwan Song
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Mass Production ◽  
Bone Substitutes ◽  
Octacalcium Phosphate ◽  
Regeneration Ability ◽  
Bovine Bone ◽  
New Bone Formation ◽  
Apatite Crystals ◽  
Biological Apatite

Octacalcium phosphate (OCP) is a precursor of biological apatite crystals that has attracted attention as a possible bone substitute. On the other hand, few studies have examined this material at the experimental level due to the limitations of OCP mass production. Recently, mass production technology of OCP was developed, and the launch of OCP bone substitutes is occurring. In this study, the bone regeneration capacity of OCP products was compared with two of the most clinically used materials: heat-treated bovine bone (BHA) and sintered biphasic calcium phosphate (BCP). Twelve rabbits were used, and defects in each tibia were filled with OCP, BHA, BCP, and left unfilled as control (CON). The tibias were harvested at 4 and 12 weeks, and 15 μm slides were prepared using the diamond grinding method after being embedded in resin. Histological and histomorphometric analyses were performed to evaluate the bone regeneration ability and mechanism. The OCP showed significantly higher resorption and new bone formation in both periods analysed (p<0.05). Overall, OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralisation), as well as providing additional space for new bone formation by rapid resorption.

scholarly journals Histological Assessment of Bone Regeneration by Octacalcium Phosphate and Bone Matrix Gelatin Composites in a Rat Mandibular Defect Model

2018 ◽  
Author(s):  
Fereydoon Sargolzaei Aval ◽  
Eshaghali Saberi ◽  
Mohammad Reza Arab ◽  
Narjes Sargolzaei ◽  
Esmaeel Zare ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Matrix ◽  
Octacalcium Phosphate ◽  
Bone Defects ◽  
Osteogenic Potential ◽  
Control Group ◽  
New Bone Formation ◽  
Mandibular Bone

Objective: Regeneration of bone defects remains a challenge for maxillofacial and reparative surgeons. The purpose of this histological study was to assess the osteogenic potential of octacalcium phosphate (OCP) and bone matrix gelatin (BMG) alone and in combination in artificially created mandibular bone defects in rats. The quality of the newly formed bone was also evaluated. Methods: Thirty-six male Sprague Dawley rats (6-8 weeks old with 120-150 g weight) were randomly divided into four groups. Defects (3 mm in diameter and 2 mm in depth) were created in the mandible of rats and filled with 6 mg of OCP, BMG or a combination of both (1/4 ratio), respectively. Defects were left unfilled in the control group. To assess osteoinduction and bone regeneration and determine the quality of the newly formed bone, tissue specimens were harvested at seven, 14, and 21 days post-implantation. The specimens were processed, stained with hematoxylin and eosin (H&E) and histologically analyzed under light microscopy. Results: In the experimental groups, new bone formation was initiated at the margins of defects from seventh day after implantation. At the end of the study period, the amount of the newly formed bone increased and the bone was relatively mature. Osteoinduction and new bone formation were greater in OCP/BMG group. In the control group, slight amount of new bone had been formed at the defect margins (next to host bone) on day 21. Conclusion: Combination of OCP/BMG may serve as an optimal biomaterial for treatment of mandibular bone defects.

Bone Regenerative Property of Octacalcium Phosphate in Mouse Critical Sized Calvarial Defects

2007 ◽  
Vol 361-363 ◽  
pp. 1253-1256
Author(s):  
Yoshitomo Honda ◽  
Shinji Kamakura ◽  
Takashi Kumagai ◽  
Osamu Suzuki
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Calcium Phosphates ◽  
Octacalcium Phosphate ◽  
Regeneration Ability ◽  
Synthesis Methods ◽  
Tartrate Resistant Acid Phosphatase ◽  
Calvarial Bone ◽  
Calvarial Defects ◽  
Wet Synthesis

Bone regeneration by calcium phosphates has been known to be intricately dependent on material properties or implanted milieu of host animals, such as site and species. Critical sized calvarial defects of mouse were recently used as the model for investigating bone regeneration ability and the mechanisms. The purpose of the present study is to investigate whether the critical sized mouse calvarial defects can be utilized to examine bone regeneration with synthetic octacalcium phosphate (OCP). OCP , prepared by wet synthesis methods, was sieved 0.3 ~ 0.5 mm in diameter and used for the animal experiment. At 14 days after surgery, histological examination showed that implantation of OCP grafted defects significantly enhanced bone formation compared with the control defect. OCP tended to convert to hydroxyapatite with time. The tartrate-resistant acid phosphatase (TRAP) positive osteoclastic cells were observed around the OCP particles. The results suggest that the mouse critical sized calvarial bone defects are useful model to investigate the bone formation by the OCP implantation.

Appositional Bone Formation by OCP-Collagen Composite

2009 ◽  
Vol 88 (12) ◽  
pp. 1107-1112 ◽  
Author(s):  
Y. Suzuki ◽  
S. Kamakura ◽  
Y. Honda ◽  
T. Anada ◽  
K. Hatori ◽  
...  
Keyword(s):  
Bone Formation ◽  
Wistar Rats ◽  
Mechanical Load ◽  
Octacalcium Phosphate ◽  
Bone Defects ◽  
Dependent Manner ◽  
X Ray Diffraction ◽  
X Ray ◽  
Appositional Bone ◽  
Induce Bone Formation

Synthetic octacalcium phosphate (OCP) has been shown to enhance bone formation and to biodegrade if implanted into bone defects. Here, we hypothesized that an OCP-atelocollagen complex (OCP/Col) is biodegradable and can induce bone formation in a thickness-dependent manner when implanted into the calvaria. OCP/Col disks (diameter, 9 mm; thickness, 1 or 3 mm) were implanted into a subperiosteal pocket in the calvaria of 12-week-old Wistar rats for 4, 8, and 12 weeks and subsequent bone formation was monitored. X-ray diffraction analysis and Fourier transform infrared spectroscopy showed that OCP in the OCP/Col implants was converted into a carbonate-rich apatite after 4 weeks. Although thinner disks tended to be replaced by new bone, thicker disks were progressively resorbed by osteoclast-like cells until 12 weeks, possibly via the increased mechanical load in the subperiosteal pocket. Therefore, OCP/Col can increase appositional intra-membranous bone formation if the appropriate size of the implant is applied.

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