Vertebral bone mineral content in osteogenesis imperfecta

1985 ◽  
Vol 37 (1) ◽  
pp. 14-18 ◽  
Author(s):  
David Kurtz ◽  
Kathleen Morrish ◽  
Jay Shapiro
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vertebral Bone

scholarly journals Serum Calcitonin and Bone Mineral Content in Patients with Osteogenesis Imperfecta

1979 ◽  
Vol 50 (6) ◽  
pp. 639-643 ◽  
Author(s):  
H. E. Nielsen ◽  
U. Pedersen ◽  
H. Hvid Hansen ◽  
O. Elbrønd
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Serum Calcitonin

Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta

Blood ◽  
2001 ◽  
Vol 97 (5) ◽  
pp. 1227-1231 ◽  
Author(s):  
Edwin M. Horwitz ◽  
Darwin J. Prockop ◽  
Patricia L. Gordon ◽  
Winston W. K. Koo ◽  
Lorraine A. Fitzpatrick ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Osteogenesis Imperfecta ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Growth Rates ◽  
Marrow Transplantation ◽  
Mineral Content ◽  
Type I ◽  
Clinical Responses

Preclinical models have shown that transplantation of marrow mesenchymal cells has the potential to correct inherited disorders of bone, cartilage, and muscle. The report describes clinical responses of the first children to undergo allogeneic bone marrow transplantation (BMT) for severe osteogenesis imperfecta (OI), a genetic disorder characterized by defective type I collagen, osteopenia, bone fragility, severe bony deformities, and growth retardation. Five children with severe OI were enrolled in a study of BMT from human leukocyte antigen (HLA)–compatible sibling donors. Linear growth, bone mineralization, and fracture rate were taken as measures of treatment response. The 3 children with documented donor osteoblast engraftment had a median 7.5-cm increase in body length (range, 6.5-8.0 cm) 6 months after transplantation compared with 1.25 cm (range, 1.0-1.5 cm) for age-matched control patients. These patients gained 21.0 to 65.3 g total body bone mineral content by 3 months after treatment or 45% to 77% of their baseline values. With extended follow-up, the patients' growth rates either slowed or reached a plateau phase. Bone mineral content continued to increase at a rate similar to that for weight-matched healthy children, even as growth rates declined. These results suggest that BMT from HLA-compatible donors may benefit children with severe OI. Further studies are needed to determine the full potential of this strategy.

The Ultimate Flexural Strength of the Lumbar Spine and Vertebral Bone Mineral Content

1993 ◽  
Vol 6 (4) ◽  
pp. 314-323 ◽  
Author(s):  
Pavel Neumann ◽  
Anna-Lisa Osvalder ◽  
Anders Nordwall ◽  
Per Lövsund ◽  
Tommy Hansson
Keyword(s):  
Lumbar Spine ◽  
Flexural Strength ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vertebral Bone

Normative Curves for Vertebral Bone Mineral Content Harry J. Griffiths, M.D

1983 ◽  
Vol 18 (4) ◽  
pp. S26
Author(s):  
Daniel Baran ◽  
Grigorios Arsenis ◽  
Daniel Prosser
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vertebral Bone

Differential effects of glucocorticoids on cortical appendicular and cortical vertebral bone mineral content

1993 ◽  
Vol 52 (1) ◽  
pp. 5-9 ◽  
Author(s):  
R. F. J. M. Laan ◽  
W. C. A. M. Buijs ◽  
L. J. Th. O. van Erning ◽  
J. A. M. Lemmens ◽  
F. H. M. Corstens ◽  
...  
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vertebral Bone ◽  
Differential Effects

Vertebral Bone Loss: An Unheeded Side Effect of Therapeutic Bed Rest

1983 ◽  
Vol 64 (5) ◽  
pp. 537-540 ◽  
Author(s):  
Bjørn Krølner ◽  
Birte Toft
Keyword(s):  
Lumbar Spine ◽  
Bone Loss ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Lumbar Vertebrae ◽  
Bed Rest ◽  
Consecutive Series ◽  
Lumbar Intervertebral Disc ◽  
Vertebral Bone

1. The skeletal effects of simple bed rest and re-ambulation were studied in a consecutive series of 34 patients (aged 18–60 years) hospitalized with low backache due to protrusion of a lumbar intervertebral disc. The bone mineral content of the second, third and fourth lumbar vertebrae was determined by dual-photon (153Gd) absorptiometry immediately after admission to the hospital, at the end of the bed-rest period (mean 27 days, range 11–61 days) and approximately 15 weeks later (range 11–24 weeks). 2. During recumbency a mean decrease in lumbar spine bone mineral content of 0.9% per week was observed. 3. Re-ambulation resulted in bone mineral gain, and restoration of lumbar spine bone mineral content was nearly complete after 4 months. 4. The findings suggest that the simple therapeutic bed-rest regimen leads to excessive vertebral bone loss. Recurrent bed-rest periods may predispose to spinal osteoporosis.

Evaluation of a prototype dual-energy computed tomographic apparatus. II. Determination of vertebral bone mineral content

1986 ◽  
Vol 13 (3) ◽  
pp. 340-343 ◽  
Author(s):  
J. R. Vetter ◽  
W. H. Perman ◽  
W. A. Kalender ◽  
R. B. Mazess ◽  
J. E. Holden
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Dual Energy ◽  
Vertebral Bone ◽  
Computed Tomographic
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