Serum markers of bone formation in parenteral nutrition patients

1990 ◽  
Vol 47 (2) ◽  
pp. 75-81 ◽  
Author(s):  
Edward W. Lipkin ◽  
Susan M. Ott ◽  
Gordon L. Klein ◽  
Leonard J. Deftos
Keyword(s):  
Bone Formation ◽  
Parenteral Nutrition ◽  
Serum Markers ◽  
Markers Of Bone Formation

Markers of Bone Formation and Resorption Identify Subgroups of Patients with Clinical Knee Osteoarthritis Who Have Reduced Rates of Cartilage Loss

2010 ◽  
Vol 37 (6) ◽  
pp. 1252-1259 ◽  
Author(s):  
PATRICIA A. BERRY ◽  
ROSE A. MACIEWICZ ◽  
FLAVIA M. CICUTTINI ◽  
MARK D. JONES ◽  
CAROLINE J. HELLAWELL ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Type I Collagen ◽  
Serum Markers ◽  
Cartilage Volume ◽  
Cartilage Loss ◽  
Type I ◽  
Bone Formation Markers ◽  
Markers Of Bone Formation ◽  
Markers Of Bone Resorption

Objective.To determine whether serum markers of bone formation and resorption, used individually or in combination, can be used to identify subgroups who lose cartilage volume at different rates over 2 years within a knee osteoarthritis (OA) population.Methods.Changes in cartilage volume over 2 years were measured in 117 subjects with knee OA using magnetic resonance imaging. We examined relationships between change in cartilage volume and baseline serum markers of bone formation [intact N-terminal propeptide of type I procollagen (PINP) and osteocalcin] and resorption [N-telopeptide of type I collagen (NTX-I), C-telopeptide of type I collagen (CTX-I), and C-telopeptide of type I collagen (ICTP).Results.The baseline markers of bone formation, PINP and osteocalcin (p = 0.02, p = 0.01, respectively), and the baseline markers of bone resorption, CTX-I and NTX-I (p = 0.02 for both), were significantly associated with reduced cartilage loss. There were no significant associations between baseline ratios of bone formation to resorption markers and cartilage loss. However, when subjects were divided into subgroups with high or low bone formation markers (based on levels of marker ≥ mean or < mean for the population, respectively), in the subgroup with high PINP there was a significant association between increasing bone resorption markers CTX-I and NTX-I and reduced cartilage loss (p = 0.02, p = 0.001, respectively). Similarly, in the subgroup with high osteocalcin, there was a significant association between increasing CTX-I and NTX-I and reduced cartilage loss (p = 0.02, p = 0.003, respectively). In contrast, in subgroups with low bone formation markers, no significant associations were obtained between markers of bone resorption and cartilage loss.Conclusion.Overall, the results suggest that higher bone remodeling (i.e., higher serum levels of bone formation and resorption) is associated with reduced cartilage loss. Considering markers of bone formation and resorption together, it is possible to identify subgroups within the OA population who have reduced rates of cartilage loss.

scholarly journals Impact of occupational health hazards on serum markers of bone formation in spray painters of Chennai region in Tamil Nadu

2012 ◽  
Vol 16 (2) ◽  
pp. 84
Author(s):  
VijayaPrakash Krishnan Muthaiah ◽  
AbelArul Nathan ◽  
Anandan Balakrishnan ◽  
Rajiv Rose ◽  
Jayaraman Gopalsamy
Keyword(s):  
Occupational Health ◽  
Bone Formation ◽  
Tamil Nadu ◽  
Serum Markers ◽  
Health Hazards ◽  
Markers Of Bone Formation

Short-term stall housing of horses results in changes of markers of bone metabolism

2019 ◽  
Vol 15 (4) ◽  
pp. 283-290
Author(s):  
A.A. Logan ◽  
B.D. Nielsen ◽  
R. Sehl ◽  
E. Jones ◽  
C.I. Robison ◽  
...  
Keyword(s):  
Bone Formation ◽  
Mineral Content ◽  
Serum Markers ◽  
Short Term ◽  
Age And Gender ◽  
Treatment Groups ◽  
The Third ◽  
Medial Cortex ◽  
And Gender ◽  
Markers Of Bone Formation

In previous research, stall-housing growing horses resulted in decreased bone mineral content (BMC) of the third metacarpal (MCIII) compared to pasture-housing. To determine whether stall confinement negatively impacts bone, regardless of age, and whether the effects could be reversed upon return to pasture, 12 mature horses (5-15 years) and 12 yearlings were pair-matched by age and gender and randomly assigned to one of two treatment groups: pasture (PT) or stall (ST). Horses on PT remained there for the 84-d study, while horses on ST spent the first 28 d in stalls and the remaining 56 d on pasture. Radiographs and blood samples were taken on d 0 for baseline determinants. Radiographs and blood were taken every 7 d for radiographic photodensitometry estimates of BMC and analysis of osteocalcin (OC) and C-telopeptide (CTX-1)-markers of bone formation and degradation. There were no differences in BMC between treatments at the medial cortex of MCIII in mature horses. There were treatment (P=0.05) and day (P<0.01) differences in BMC at the lateral cortex of MCIII. In yearling horses, the BMC of the medial cortex of MCIII had a day difference with the lowest overall average at d 21 and highest at d 70 (P=0.04). There were day by treatment differences (P<0.05) for both OC and CTX-1 with the mature and yearling horses on ST having lower OC on d 14 than PT horses (P<0.05) indicative of reduced bone formation. In mature and yearling ST horses, CTX-1 was greater on d 14 and 28 compared to horses on PT (P≤0.05) suggesting greater bone resorption. Results from serum markers of bone formation and deformation confirm that stalling negatively impacts bone formation in horses regardless of age.

Changes in bone metabolism associated with exposure to industrial vibration

2020 ◽  
pp. 766-766
Author(s):  
A. V. Sukhova ◽  
E. N. Kryuchkova
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Local Vibration ◽  
Markers Of Bone Formation

The influence of general and local vibration on bone remodeling processes is investigated. The interrelations between the long - term exposure of industrial vibration and indicators of bone mineral density (T-and Z-criteria), biochemical markers of bone formation (osteocalcin, alkaline phosphatase) and bone resorption (ionized calcium, calcium/creatinine) were established.

Biochemical markers of bone formation in hypopituitary adults

1992 ◽  
Vol 17 ◽  
pp. 222
Author(s):  
S.A. Beshyah ◽  
P.A. Kyd ◽  
P. Sharp ◽  
D.G. Johnston ◽  
A. Fairney
Keyword(s):  
Bone Formation ◽  
Biochemical Markers ◽  
Markers Of Bone Formation
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