Vertebral bone resorptionin vitro: Effects of parathyroid hormone, calcitonin, 1,25 dihydroxyvitamin D3, epidermal growth factor, prostaglandin E2, and estrogen

1987 ◽  
Vol 40 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Pamela J. Stewart ◽  
Paula H. Stern
Keyword(s):  
Parathyroid Hormone ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Prostaglandin E2 ◽  
Dihydroxyvitamin D3 ◽  
Vertebral Bone ◽  
1,25 Dihydroxyvitamin D3 ◽  
Epidermal Growth

scholarly journals Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3-E1) by epidermal growth factor.

1986 ◽  
Vol 261 (33) ◽  
pp. 15410-15415
Author(s):  
K Yokota ◽  
M Kusaka ◽  
T Ohshima ◽  
S Yamamoto ◽  
N Kurihara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Prostaglandin E2 ◽  
Osteoblastic Cells ◽  
Epidermal Growth ◽  
Stimulation Of

Renal synthesis of epidermal growth factor is unchanged by vitamin D deficiency

1990 ◽  
Vol 68 (6) ◽  
pp. 733-736 ◽  
Author(s):  
Paul R. Goodyer ◽  
Sharon Langshur ◽  
Jehane Fata
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Vitamin D Deficiency ◽  
Thick Ascending Limb ◽  
Mrna Levels ◽  
Luminal Membrane ◽  
Calcium Reabsorption ◽  
Epidermal Growth

In mammalian kidney, epidermal growth factor (EGF) is produced as a small internal domain of an abundant high molecular weight peptide associated with the luminal membrane of the thick ascending limb of Henle's loop and distal convoluted tubule. At present, there is no evidence to indicate a mitogenic function for the EGF-containing molecule in kidney; consideration of its molecular structure suggests the possibility of a membrane-associated physiologic role. In this study, we examine regulation of renal EGF synthesis during induction of vitamin D deficiency in mice. Despite evidence of marked hyperparathyroidism, urinary excretion of EGF was equivalent in control (2.54 ± 0.72 μg/mg creatinine) and vitamin D deficient (2.13 ± 0.97 μg/mg creatinine) animals. Similarly, EGF mRNA levels in kidney were comparable in the two groups. These data indicate that parathyroid hormone has no effect on renal EGF regulation, although it is known to stimulate calcium reabsorption in distal nephron segments.Key words: epidermal growth factor, vitamin D, calcium, kidney, parathyroid hormone.

Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone

Bone ◽  
2012 ◽  
Vol 50 (1) ◽  
pp. 237-244 ◽  
Author(s):  
Marlon R. Schneider ◽  
Maik Dahlhoff ◽  
Olena Andrukhova ◽  
Jessica Grill ◽  
Martin Glösmann ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Parathyroid Hormone ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Receptor Signaling ◽  
Epidermal Growth ◽  
Growth Factor Receptor Signaling
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