The effects of chronic dietary calcium supplementation on bone mineral density in ovariectomized Beagles

1988 ◽  
Vol 43 (2) ◽  
pp. 122-124 ◽  
Author(s):  
M. -S. Shih ◽  
J. Dixon ◽  
C. Anderson
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Mineral Density ◽  
Ovariectomized Beagles

Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction

2009 ◽  
Vol 10 (6) ◽  
pp. 910-920 ◽  
Author(s):  
Hiroyuki Motoie ◽  
Toshitaka Nakamura ◽  
Naoto O'Uchi ◽  
Haruko Nishikawa ◽  
Hiroyuki Kanoh ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Dietary Calcium ◽  
Mineral Density ◽  
Ovariectomized Beagles

scholarly journals Dietary calcium, protein, and phosphorus are related to bone mineral density and content in young women

1998 ◽  
Vol 68 (3) ◽  
pp. 749-754 ◽  
Author(s):  
D Teegarden ◽  
R M Lyle ◽  
G P McCabe ◽  
L D McCabe ◽  
W R Proulx ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Young Women ◽  
Dietary Calcium ◽  
Mineral Density

scholarly journals Effects of vitamin D and calcium supplementation on bone mineral density among Thai youth using daily HIV pre‐exposure prophylaxis

2020 ◽  
Vol 23 (10) ◽  
Author(s):  
Krittaporn Pornpaisalsakul ◽  
Wipaporn Natalie Songtaweesin ◽  
Supatporn Tepmongkol ◽  
Prissana Wongharn ◽  
Surinda Kawichai ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Calcium Supplementation ◽  
Mineral Density ◽  
Exposure Prophylaxis

scholarly journals Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study

BMJ ◽  
2019 ◽  
pp. l4410 ◽  
Author(s):  
Agustin Cerani ◽  
Sirui Zhou ◽  
Vincenzo Forgetta ◽  
John A Morris ◽  
Katerina Trajanoska ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Genetic Predisposition ◽  
Calcium Supplementation ◽  
Meta Analysis ◽  
Mendelian Randomisation ◽  
Uk Biobank ◽  
Mineral Density ◽  
The Uk

Abstract Objective To determine if genetically increased serum calcium levels are associated with improved bone mineral density and a reduction in osteoporotic fractures. Design Mendelian randomisation study. Setting Cohorts used included: the UK Biobank cohort, providing genotypic and estimated bone mineral density data; 25 cohorts from UK, USA, Europe, and China, providing genotypic and fracture data; and 17 cohorts from Europe, providing genotypic and serum calcium data (summary level statistics). Participants A genome-wide association meta-analysis of serum calcium levels in up to 61 079 individuals was used to identify genetic determinants of serum calcium levels. The UK Biobank study was used to assess the association of genetic predisposition to increased serum calcium with estimated bone mineral density derived from heel ultrasound in 426 824 individuals who had, on average, calcium levels in the normal range. A fracture genome-wide association meta-analysis comprising 24 cohorts and the UK Biobank including a total of 76 549 cases and 470 164 controls, who, on average, also had calcium levels in the normal range was then performed. Results A standard deviation increase in genetically derived serum calcium (0.13 mmol/L or 0.51 mg/dL) was not associated with increased estimated bone mineral density (0.003 g/cm 2 , 95% confidence interval −0.059 to 0.066; P=0.92) or a reduced risk of fractures (odds ratio 1.01, 95% confidence interval 0.89 to 1.15; P=0.85) in inverse-variance weighted mendelian randomisation analyses. Sensitivity analyses did not provide evidence of pleiotropic effects. Conclusions Genetic predisposition to increased serum calcium levels in individuals with normal calcium levels is not associated with an increase in estimated bone mineral density and does not provide clinically relevant protection against fracture. Whether such predisposition mimics the effect of short term calcium supplementation is not known. Given that the same genetically derived increase in serum calcium is associated with an increased risk of coronary artery disease, widespread calcium supplementation in the general population could provide more risk than benefit.

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