Sexual function and perineal wound healing after intersphincteric excision of the rectum for inflammatory bowel disease

1984 ◽  
Vol 27 (4) ◽  
pp. 244-248 ◽  
Author(s):  
R. J. Leicester ◽  
Jean K. Ritchie ◽  
Jane Wadsworth ◽  
J. P. S. Thomson ◽  
P. R. Hawley
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Sexual Function ◽  
Bowel Disease ◽  
Perineal Wound ◽  
Perineal Wound Healing ◽  
Inflammatory Bowel

Perineal wound healing after proctectomy for inflammatory bowel disease

1978 ◽  
Vol 21 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Marvin L. Corman ◽  
Malcolm C. Veidenheimer ◽  
John A. Coller ◽  
Virginia H. Ross
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Perineal Wound ◽  
Perineal Wound Healing ◽  
Inflammatory Bowel

Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

2018 ◽  
Vol 13 (5) ◽  
pp. 659-668 ◽  
Author(s):  
Sara Lovisa ◽  
Giannicola Genovese ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Molecular Mechanisms ◽  
Epithelial To Mesenchymal Transition ◽  
Clinical Manifestations ◽  
Mesenchymal Transition ◽  
Intestinal Fibrosis ◽  
Inflammatory Bowel

Abstract Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn’s disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.

Sa1859 SEXUAL FUNCTION AND CONTRACEPTION USE IN WOMEN WITH INFLAMMATORY BOWEL DISEASE

2020 ◽  
Vol 158 (6) ◽  
pp. S-454
Author(s):  
Nichola R. Haddad ◽  
Farnoosh Feiz ◽  
Kristen Petagna ◽  
Christy Dibble
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sexual Function ◽  
Bowel Disease ◽  
Contraception Use ◽  
Inflammatory Bowel

scholarly journals Sexual Health in Women with Inflammatory Bowel Disease in the Danish National Birth Cohort

2020 ◽  
Vol 14 (8) ◽  
pp. 1082-1089
Author(s):  
Ellen A Nøhr ◽  
Jan Nielsen ◽  
Bente M Nørgård ◽  
Sonia Friedman
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sexual Dysfunction ◽  
Sexual Health ◽  
Sexual Function ◽  
Birth Cohort ◽  
Bowel Disease ◽  
Large Population ◽  
Danish National Birth Cohort ◽  
Increased Risk ◽  
Inflammatory Bowel

Abstract Background and Aims Previous studies indicate an increased risk of sexual dysfunction in women with inflammatory bowel disease [IBD] but none have examined sexual function in a large population-based cohort. Methods To investigate the risk of sexual dysfunction in women with IBD, we used data from the Danish National Birth Cohort, a nationwide study of 92 274 pregnant women recruited during 1996–2002. We performed a cross-sectional study based on mothers who participated in the Maternal Follow-up in 2013–14. The outcome was self-reported sexual health. Information regarding demographics and IBD characteristics was retrieved from the Danish National Patient Register. Using regression models and adjusting for important confounders, we compared sexual function in women with and without IBD. Results The study population consisted of 38 011 women including 196 [0.5%] with Crohn’s disease [CD] and 409 [1.1%] with ulcerative colitis [UC]. Median age was 44 years. Compared to women without IBD, women with UC did not have significantly decreased sexual function, while women with CD had more difficulty achieving orgasm (adjusted odds ratio [aOR] 1.53; 95% confidence interval [CI] 1.02–2.30], increased dyspareunia [aOR 1.71; 95% CI 1.11–2.63] and deep dyspareunia [aOR 2.00; 95% CI 1.24–3.22]. The risk for difficulty achieving orgasm and deep dyspareunia was further increased within 2 years of an IBD-related contact/visit [aOR 1.81; 95% CI 1.11–2.95; and aOR 2.37; 95% CI 1.34–4.19]. Conclusions Women with CD have significantly increased difficulty achieving orgasm and increased dyspareunia. Physicians should be cognizant of and screen for sexual dysfunction in this group of patients.

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