Approximations for optimal stopping of a piecewise-deterministic process

1988 ◽  
Vol 1 (2) ◽  
pp. 123-146 ◽  
Author(s):  
O. L. V. Costa ◽  
M. H. A. Davis
2020 ◽  
Vol 81 (7) ◽  
pp. 1192-1210
Author(s):  
O.V. Zverev ◽  
V.M. Khametov ◽  
E.A. Shelemekh

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 284
Author(s):  
Yu-Hao Liu ◽  
Chien-Chang Chen ◽  
Yi-Jen Hsueh ◽  
Li-Man Hung ◽  
David Hui-Kang Ma ◽  
...  

Although several modes of reprogramming have been reported in different cell types during iPSC induction, the molecular mechanism regarding the selection of different modes of action is still mostly unknown. The present study examined the molecular events that participate in the selection of such processes at the onset of somatic reprogramming. The activity of STAT3 versus that of Erk1/2 reversibly determines the reprogramming mode entered; a lower activity ratio favors the deterministic process and vice versa. Additionally, extraneous E-cadherin facilitates the early events of somatic reprogramming, potentially by stabilizing the LIF/gp130 and EGFR/ErbB2 complexes to promote entry into the deterministic process. Our current findings demonstrated that manipulating the pSTAT3/pErk1/2 activity ratio in the surrounding milieu can drive different modes of action toward either the deterministic or the stochastic process in the context of OSKM-mediated somatic reprogramming.


Mathematics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 534
Author(s):  
F. Thomas Bruss

This paper presents two-person games involving optimal stopping. As far as we are aware, the type of problems we study are new. We confine our interest to such games in discrete time. Two players are to chose, with randomised choice-priority, between two games G1 and G2. Each game consists of two parts with well-defined targets. Each part consists of a sequence of random variables which determines when the decisive part of the game will begin. In each game, the horizon is bounded, and if the two parts are not finished within the horizon, the game is lost by definition. Otherwise the decisive part begins, on which each player is entitled to apply their or her strategy to reach the second target. If only one player achieves the two targets, this player is the winner. If both win or both lose, the outcome is seen as “deuce”. We motivate the interest of such problems in the context of real-world problems. A few representative problems are solved in detail. The main objective of this article is to serve as a preliminary manual to guide through possible approaches and to discuss under which circumstances we can obtain solutions, or approximate solutions.


2021 ◽  
Vol 136 ◽  
pp. 125-144
Author(s):  
Damian Jelito ◽  
Marcin Pitera ◽  
Łukasz Stettner

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