The effects of dietary protein on the fatty acid composition and Δ6 desaturase activity of rat hepatic microsomes

Lipids ◽  
1991 ◽  
Vol 26 (2) ◽  
pp. 107-110 ◽  
Author(s):  
Marie Lindholm ◽  
Anders Eklúnd
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Dietary Protein ◽  
Desaturase Activity ◽  
Hepatic Microsomes ◽  
Δ6 Desaturase

scholarly journals Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and Δ5-, Δ6-desaturase protein expression in steer muscles

animal ◽  
2012 ◽  
Vol 6 (12) ◽  
pp. 1973-1984 ◽  
Author(s):  
T.D. Turner ◽  
A. Mitchell ◽  
J. Duynisveld ◽  
J. Pickova ◽  
O. Doran ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Protein Expression ◽  
Acid Composition ◽  
Δ6 Desaturase

scholarly journals The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet

1982 ◽  
Vol 206 (3) ◽  
pp. 561-570 ◽  
Author(s):  
M Enser ◽  
J L Roberts
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Food Intake ◽  
Acid Composition ◽  
Desaturase Activity ◽  
Corn Oil ◽  
Saturated Fat ◽  
Obese Mice ◽  
Commercial Diet

1. The effects of food intake and the fatty acid composition of the diet on the hepatic stearoyl-CoA desaturase activity of obese-hyperglycaemic (ob/ob) mice were investigated. 2. Obese mice fed on a commercial mouse diet, ad libitum, had 6.5-fold more activity per liver cell than had lean mice. 3. On a diet containing 14% corn oil the activity was 65% less in obese mice and 62% less in lean mice compared with animals fed on the commercial diet. 4. Feeding with 14% saturated fat in the diet doubled the activity in lean mice compared with those on the commercial diet, but had no effect on the activity in obese mice. 5. Obese mice fed on the corn-oil diet contained a higher proportion of linoleic acid in the liver lipids than did lean mice fed on the commercial diet, but the acyl-CoA desaturase activity was 125% higher than in the lean mice. 6. Limiting the food intake of obese mice by pair-feeding with lean mice decreased their acyl-CoA desaturase activity when the animals were fed on the saturated-fat diet, but the activity remained 75% higher than in lean mice, whereas in obese mice pair-fed on the corn-oil diet the activity was the same as in lean mice. 7. During starvation the acyl-CoA desaturase activity in livers from obese mice decreased more slowly and proportionately less than in livers from lean mice. 8. It is concluded that increased substrate supply as a result of hyperphagia and not low concentration of linoleic acid is the main factor causing high acyl-CoA desaturase activity in obese mice.

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