Structural importance of thecis-5 ethylenic bond in the endogenous desaturation product of dietary elaidic acid,cis-5,trans-9 18∶2 acid, for the acylation of rat mitochondria phosphatidylinositol

Lipids ◽  
1995 ◽  
Vol 30 (10) ◽  
pp. 893-898 ◽  
Author(s):  
Robert L. Wolff
Keyword(s):  
Elaidic Acid ◽  
Ethylenic Bond ◽  
Structural Importance

Elaidic Acid and Serum Lipoproteins in Starved and Fed Rats

1973 ◽  
Vol 15 (4-5) ◽  
pp. 281-289 ◽  
Author(s):  
Demetrios Sgoutas ◽  
Rosanne Jones ◽  
Paul Befanis
Keyword(s):  
Elaidic Acid ◽  
Serum Lipoproteins

scholarly journals Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet.

1992 ◽  
Vol 33 (7) ◽  
pp. 1029-1036
Author(s):  
P Nestel ◽  
M Noakes ◽  
B Belling ◽  
R McArthur ◽  
P Clifton ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Elaidic Acid ◽  
Plasma Lipoprotein ◽  
Lipoprotein Lipid

A study of the reaction of 2-pyridyl isothiocyanate with azoimide

1982 ◽  
Vol 47 (3) ◽  
pp. 877-883 ◽  
Author(s):  
Miroslav Marchalín ◽  
František Považanec ◽  
Augustin Martvoň
Keyword(s):  
Elemental Sulfur ◽  
Ethylenic Bond ◽  
Mechanism Of The Reaction

From the reaction mixture of 2-pyridyl isothiocyanate with azoimide in dioxane 5-(2-pyridyl-amino)tetrzole, 2-pyridylthiourea and elemental sulfur were isolated instead of the expected 5-(2-pyridylamino)-1,2,3,4-thiatriazole. The mechanism of the reaction mentioned was studied on the basis of the synthesis of the assumed intermediates and the isolation of the intermediates by means of compounds with an activated acetylenic or ethylenic bond.

scholarly journals Distinct effects of oleic acid and itstrans-isomer elaidic acid on the expression of myokines and adipokines in cell models

2011 ◽  
Vol 105 (8) ◽  
pp. 1226-1234 ◽  
Author(s):  
Nuria Granados ◽  
Jaume Amengual ◽  
Joan Ribot ◽  
Andreu Palou ◽  
M. Luisa Bonet
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Oleic Acid ◽  
Insulin Sensitivity ◽  
Glucose Uptake ◽  
Elaidic Acid ◽  
C2c12 Myotubes ◽  
Cell Models ◽  
Monounsaturated Fat ◽  
Expression Levels

Trans-fatty acids (TFA) andcis-monounsaturated fat appear to exert detrimental and beneficial effects, respectively, on glucose metabolism and insulin sensitivity. Adipose tissue and skeletal muscle are a source of signalling proteins (adipokines and myokines), some of which have been related to the control of insulin sensitivity. Here, we investigated the possible differential effects of elaidic acid (EA;trans-9-18 : 1) – the major component in industrially produced TFA – and oleic acid (OA;cis-9-18 : 1) – itscis-isomer naturally present in food – on cellular glucose uptake and the expression of selected myokines and adipokines using cell models. Differentiated C2C12 myotubes and 3T3-L1 adipocytes were pretreated with the vehicle (control cells) or fatty acids for 24 h, after which basal and insulin-stimulated 2-deoxyglucose uptake and the expression of selected signalling proteins were measured. In C2C12 myotubes, pretreatment with OA, but not with EA, led to increased insulin-stimulated 2-deoxyglucose uptake and IL-6 expression levels, while pretreatment with EA, but not with OA, led to reduced IL-15 mRNA levels and increased TNF-α expression levels. In 3T3-L1 adipocytes, exposure to OA, but not to EA, resulted in reduced resistin gene expression and increased adiponectin gene expression. The results show evidence of distinct, direct effects of OA and EA on muscle glucose uptake and the expression of target myokines and adipokines, thus suggesting novel mechanisms by whichcis- andtrans-monounsaturated fat may differentially affect systemic functions.

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