Measurement of bile acid synthesis in man by release of14CO2 from [26-14C]cholesterol: Comparison to isotope dilution and assessment of optimum reference cholesterol specific activity

Lipids ◽  
1992 ◽  
Vol 27 (1) ◽  
pp. 68-71 ◽  
Author(s):  
John C. Mitchell ◽  
Bradford G. Stone ◽  
William C. Duane
Keyword(s):  
Bile Acid ◽  
Isotope Dilution ◽  
Specific Activity ◽  
Acid Synthesis ◽  
Bile Acid Synthesis

Comparison of bile acid synthesis determined by isotope dilution versus fecal acidic sterol output in human subjects

Lipids ◽  
1982 ◽  
Vol 17 (5) ◽  
pp. 345-348 ◽  
Author(s):  
William C. Duane ◽  
David E. Holloway ◽  
Scot W. Hutton ◽  
Patricia J. Corcoran ◽  
Nancy A. Haas
Keyword(s):  
Bile Acid ◽  
Isotope Dilution ◽  
Human Subjects ◽  
Acid Synthesis ◽  
Bile Acid Synthesis

scholarly journals Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis

1991 ◽  
Vol 276 (1) ◽  
pp. 73-77 ◽  
Author(s):  
B Ugele ◽  
H J M Kempen ◽  
R Gebhardt ◽  
P Meijer ◽  
H J Burger ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Rat Liver ◽  
Mass Production ◽  
Enterohepatic Circulation ◽  
Specific Activity ◽  
Liver Parenchyma ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Feedback Suppression

Periportal and perivenous hepatocytes were isolated from rat liver by digitonin/collagenase perfusion for investigating the acinar distribution of bile acid synthesis. The specific activity of cholesterol 7 alpha-hydroxylase (EC 1.14.13.17) was 7.9-fold higher in perivenous cells than in periportal hepatocytes. Mass production of bile acids differed 4.4-fold between cultured perivenous and periportal hepatocytes. In contrast, the levels of free cholesterol in homogenates and microsomes derived from both subfractions were similar. Feeding of rats with the bile-acid-sequestering anion-exchange resin colestid resulted in a pronounced stimulation of cholesterol 7 alpha-hydroxylase activity and bile acid mass production, but decreased the perivenous/periportal ratio of both parameters. These results demonstrate that bile acid mass production, but decreased the perivenous hepatocytes, possibly owing to feedback suppression by bile acids from the enterohepatic circulation. Furthermore, the opposite acinar localization of cholesterol and bile acid biosynthesis provides an interesting alternative to current views of the regulation of their metabolic pathways.

scholarly journals Endogenous Estrogens Lower Plasma PCSK9 and LDL Cholesterol But Not Lp(a) or Bile Acid Synthesis in Women

2012 ◽  
Vol 32 (3) ◽  
pp. 810-814 ◽  
Author(s):  
Lena Persson ◽  
Peter Henriksson ◽  
Eli Westerlund ◽  
Outi Hovatta ◽  
Bo Angelin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ldl Cholesterol ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Lower Plasma

scholarly journals Bile Acid Synthesis Disorders in Japan: Long-Term Outcome and Chenodeoxycholic Acid Treatment

2021 ◽  
Author(s):  
Akihiko Kimura ◽  
Tatsuki Mizuochi ◽  
Hajime Takei ◽  
Akira Ohtake ◽  
Jun Mori ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chenodeoxycholic Acid ◽  
Acid Treatment ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Manipulating the Microbiome: An Alternative Treatment for Bile Acid Diarrhoea

2021 ◽  
Vol 12 (2) ◽  
pp. 335-353
Author(s):  
Evette B. M. Hillman ◽  
Sjoerd Rijpkema ◽  
Danielle Carson ◽  
Ramesh P. Arasaradnam ◽  
Elizabeth M. H. Wellington ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Gastrointestinal Disease ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Metabolism ◽  
The United Kingdom ◽  
The 1960S ◽  
Irritable Bowel ◽  
The Uk

Bile acid diarrhoea (BAD) is a widespread gastrointestinal disease that is often misdiagnosed as irritable bowel syndrome and is estimated to affect 1% of the United Kingdom (UK) population alone. BAD is associated with excessive bile acid synthesis secondary to a gastrointestinal or idiopathic disorder (also known as primary BAD). Current licensed treatment in the UK has undesirable effects and has been the same since BAD was first discovered in the 1960s. Bacteria are essential in transforming primary bile acids into secondary bile acids. The profile of an individual’s bile acid pool is central in bile acid homeostasis as bile acids regulate their own synthesis. Therefore, microbiome dysbiosis incurred through changes in diet, stress levels and the introduction of antibiotics may contribute to or be the cause of primary BAD. This literature review focuses on primary BAD, providing an overview of bile acid metabolism, the role of the human gut microbiome in BAD and the potential options for therapeutic intervention in primary BAD through manipulation of the microbiome.

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