Platelet-activating factor (PAF) induces contraction of saponin-skinned smooth muscle of coronary artery

Lipids ◽  
1991 ◽  
Vol 26 (12) ◽  
pp. 1274-1276 ◽  
Author(s):  
A. I. Soloviev ◽  
P. Braquet
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Platelet Activating Factor ◽  
Skinned Smooth Muscle

Properties of the sarcoplasmic reticulum Ca2+-pump in coronary artery skinned smooth muscle

1995 ◽  
Vol 151 (2) ◽  
pp. 149-155 ◽  
Author(s):  
A. B. Elmoselhi ◽  
M. Blennerhassett ◽  
S. E. Samson ◽  
A. K. Grover
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Sarcoplasmic Reticulum ◽  
Skinned Smooth Muscle

scholarly journals Myorelaxant Effect of the Dysphania ambrosioides Essential Oil on Sus scrofa domesticus Coronary Artery and Its Toxicity in the Drosophila melanogaster Model

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2041
Author(s):  
Luiz Jardelino de Lacerda Neto ◽  
Andreza Guedes Barbosa Ramos ◽  
Renata Evaristo Rodrigues da Silva ◽  
Luís Pereira-de-Morais ◽  
Fernanda Maria Silva ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Essential Oil ◽  
Coronary Arteries ◽  
Sus Scrofa ◽  
Ex Vivo ◽  
Alternative Methods ◽  
Major Constituent ◽  
Sus Scrofa Domesticus

Purpose: Alternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R’s (replacement, reduction and refinement) has been an important reference, such that in vitro, ex vivo and cord replacement methods have achieved a prominent place in research. Methods: Therefore, due to successful results from studies developed with these methods, the present study aimed to evaluate the myorelaxant effect of the Dysphania ambrosioides essential oil (EODa) using a Sus scrofa domesticus coronary artery model, and the toxicity of both the Dysphania ambrosioides essential oil and its major constituent, α-terpinene, against Drosophila melanogaster in toxicity and negative geotaxis assays. Results: The EODa relaxed the smooth muscle of swine coronary arteries precontracted with K+ and 5-HT in assays using Sus scrofa domesticus coronary arteries. The toxicity results presented LC50 values of 1.546 mg/mL and 2.282 mg/mL for the EODa and α-terpinene, respectively, thus showing the EODa and α-terpinene presented toxicity to these dipterans, with the EODa being more toxic. Conclusions: Moreover, the results reveal the possibility of using the EODa in vascular disease studies since it promoted the relaxation of the Sus scrofa domesticus coronary smooth muscle.

Regulation of Ca2+ sensitivity in alpha-toxin skinned smooth muscle

1992 ◽  
Vol 24 ◽  
pp. 36
Author(s):  
Cornelis van Breemen ◽  
Junji Nishimura ◽  
Suzanne Moreland ◽  
Robert S. Moreland
Keyword(s):  
Smooth Muscle ◽  
Alpha Toxin ◽  
Skinned Smooth Muscle
Sign in / Sign up

Export Citation Format

Share Document