The Effects of dietary n−3/n−6 ratio on brain development in the mouse: a dose response study with long-chain n−3 fatty acids

Lipids ◽  
1992 ◽  
Vol 27 (2) ◽  
pp. 98-103 ◽  
Author(s):  
P. E. Wainwright ◽  
Y. S. Huang ◽  
B. Bulman-Fleming ◽  
D. Dalby ◽  
D. E. Mills ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Brain Development ◽  
Dose Response ◽  
Dose Response Study ◽  
Long Chain

Ethanol-induced decreases in membrane long-chain unsaturated fatty acids correlate with impaired chick brain development

1996 ◽  
Vol 115 (4) ◽  
pp. 465-474 ◽  
Author(s):  
Robert R. Miller ◽  
Christina L. Taylor ◽  
Deborah L. Spidle ◽  
Angela M. Ugolini ◽  
Randall A. Nothdorf
Keyword(s):  
Fatty Acids ◽  
Brain Development ◽  
Unsaturated Fatty Acids ◽  
Chick Brain ◽  
Long Chain

scholarly journals Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1185
Author(s):  
Maud Martinat ◽  
Moïra Rossitto ◽  
Mathieu Di Miceli ◽  
Sophie Layé
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Brain Development ◽  
Essential Fatty Acids ◽  
Developing Brain ◽  
Hyperactivity Disorder ◽  
Brain Functions ◽  
Dietary Polyunsaturated Fatty Acids ◽  
Long Chain

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for brain functions. They constitute crucial elements of cellular membranes, especially in the brain. They are the precursors of several metabolites with different effects on inflammation and neuron outgrowth. Overall, long-chain PUFAs accumulate in the offspring brain during the embryonic and post-natal periods. In this review, we discuss how they accumulate in the developing brain, considering the maternal dietary supply, the polymorphisms of genes involved in their metabolism, and the differences linked to gender. We also report the mechanisms linking their bioavailability in the developing brain, their transfer from the mother to the embryo through the placenta, and their role in brain development. In addition, data on the potential role of altered bioavailability of long-chain n-3 PUFAs in the etiologies of neurodevelopmental diseases, such as autism, attention deficit and hyperactivity disorder, and schizophrenia, are reviewed.

scholarly journals Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n−3 fatty acids

1999 ◽  
Vol 70 (3) ◽  
pp. 331-337 ◽  
Author(s):  
Jeppe Hagstrup Christensen ◽  
Merete Stubkjœr Christensen ◽  
Jørn Dyerberg ◽  
Erik Berg Schmidt
Keyword(s):  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Fatty Acid ◽  
Blood Cell ◽  
Dose Response ◽  
Acid Content ◽  
Cell Membranes ◽  
Fatty Acid Content ◽  
Dose Response Study

Resistance to very-long-chain fatty-acid (VLCFA)-inhibiting herbicides in multiple field-selected rigid ryegrass (Lolium rigidum) populations

Weed Science ◽  
2019 ◽  
Vol 67 (3) ◽  
pp. 267-272 ◽  
Author(s):  
David J. Brunton ◽  
Peter Boutsalis ◽  
Gurjeet Gill ◽  
Christopher Preston
Keyword(s):  
Fatty Acid ◽  
Dose Response ◽  
Chain Fatty Acid ◽  
Lolium Rigidum ◽  
Long Chain Fatty Acid ◽  
First Case ◽  
Rigid Ryegrass ◽  
Multiple Field ◽  
Dose Response Study ◽  
Long Chain

AbstractFive populations of rigid ryegrass (Lolium rigidumGaudin) from fields across cropping regions in southern Australia were suspected of having resistance to thiocarbamates, chloroacetamides, and sulfonylisoxazoline herbicides. Resistant (R) populations 375-14, 198-15, 16.2, EP162, RAC1, and A18 and two susceptible (S) populations (SLR4 and VLR1) were included in a dose–response study. All suspected R populations expressed resistance to one or all herbicides (thiocarbamates, chloroacetamides, and pyroxasulfone). Population 198-15 exhibited the highest LD50to triallate (44.7-fold), prosulfocarb (45.7-fold),S-metolachlor (31.5-fold), and metazachlor (27.2-fold) compared with the S populations. Populations 198-15 and 375-14 were also resistant to pyroxasulfone (13.5- and 14.9-fold) compared with the S populations, as was population EP162. This study documents the first case of field-evolved resistance to thiocarbamate, chloroacetamide, and sulfonylisoxazoline herbicides inL. rigidum.

scholarly journals Original Research: Effect of various dietary fats on fatty acid profile in duck liver: Efficient conversion of short-chain to long-chain omega-3 fatty acids

2016 ◽  
Vol 242 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Xi Chen ◽  
Xue Du ◽  
Jianliang Shen ◽  
Lizhi Lu ◽  
Weiqun Wang
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Dose Response ◽  
Flaxseed Oil ◽  
Dietary Fats ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 6 ◽  
Long Chain

Omega-3 fatty acids, especially long-chain omega-3 fatty acids, have been associated with potential health benefits for chronic disease prevention. Our previous studies found that dietary omega-3 fatty acids could accumulate in the meat and eggs in a duck model. This study was to reveal the effects of various dietary fats on fatty acid profile and conversion of omega-3 fatty acids in duck liver. Female Shan Partridge Ducks were randomly assigned to five dietary treatments, each consisting of 6 replicates of 30 birds. The experimental diets substituted the basal diet by 2% of flaxseed oil, rapeseed oil, beef tallow, or fish oil, respectively. In addition, a dose response study was further conducted for flaxseed and fish oil diets at 0.5%, 1%, and 2%, respectively. At the end of the five-week treatment, fatty acids were extracted from the liver samples and analyzed by GC-FID. As expected, the total omega-3 fatty acids and the ratio of total omega-3/omega-6 significantly increased in both flaxseed and fish oil groups when compared with the control diet. No significant change of total saturated fatty acids or omega-3 fatty acids was found in both rapeseed and beef tallow groups. The dose response study further indicated that 59–81% of the short-chain omega-3 ALA in flaxseed oil-fed group was efficiently converted to long-chain DHA in the duck liver, whereas 1% of dietary flaxseed oil could produce an equivalent level of DHA as 0.5% of dietary fish oil. The more omega-3 fatty acids, the less omega-6 fatty acids in the duck liver. Taken together, this study showed the fatty acid profiling in the duck liver after various dietary fat consumption, provided insight into a dose response change of omega-3 fatty acids, indicated an efficient conversion of short- to long-chain omega-3 fatty acid, and suggested alternative long-chain omega-3 fatty acid-enriched duck products for human health benefits.

scholarly journals Effects of Marine-Derived Omega-3 Fatty Acids on Systemic Hemodynamics at Rest and During Stress: a Dose–Response Study

2012 ◽  
Vol 44 (3) ◽  
pp. 301-308 ◽  
Author(s):  
Ann C. Skulas-Ray ◽  
Penny M. Kris-Etherton ◽  
William S. Harris ◽  
Sheila G. West
Keyword(s):  
Fatty Acids ◽  
Dose Response ◽  
Systemic Hemodynamics ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Dose Response Study
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