Cardiac membrane vitamin E and malondialdehyde levels in heart muscle of normotensive and spontaneously-hypertensive rats

Lipids ◽  
1989 ◽  
Vol 24 (1) ◽  
pp. 33-38 ◽  
Author(s):  
David R. Janero ◽  
Barbara Burghardt
Keyword(s):  
Vitamin E ◽  
Heart Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cardiac Membrane

Vitamin E prevents the decrease of cellular immune function with aging in spontaneously hypertensive rats

1995 ◽  
Vol 15 (3) ◽  
pp. 401-414 ◽  
Author(s):  
Satoru Moriguchi ◽  
Keisei Maekawa ◽  
Mariko Okamura ◽  
Keiko Oonishi ◽  
Yasuo Kishino
Keyword(s):  
Vitamin E ◽  
Immune Function ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cellular Immune Function ◽  
Cellular Immune

Kinetic Study of Thrombogenesis on Stroke-Prone Spontaneously Hypertensive Rats (SHRSP). The Effect of Platelet-Inhibiting Drug and Vitamin E.

1979 ◽  
Author(s):  
A. Kuramoto ◽  
H. Okita ◽  
S. Koganemaru
Keyword(s):  
Blood Pressure ◽  
Vitamin E ◽  
Survival Time ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Salt Loading ◽  
Spontaneously Hypertensive ◽  
Platelet Production ◽  
Platelet Survival ◽  
Deficient Group

The increase of platelet production was demonstrated in stroke-prone SHR(SHRSP) after 10 weeks of age, probably due to increased platelet consumption compared with those in stroke-resistant SHR(SHRSR)(Koganemaru, S., et al. Thrombus. Haemostas.(Stuttgart)38:139, 1977). We extended our study to see the effect of aging, blood pressure, platelet-inhibiting drug and vitamin E(Vit.E) on this kinetic change. SHRSP(A1-sbF37-39) and SHRSR (BlF36-38) with matched age (5 weeks, 10 weeks and 9-12 months) and sex were used. The maximum uptake of 75se-methionine(75SeM) into platelets was not affected in both salt loading group and Clonidine group in SHRSP. A significant decrease was observed in dipyridamole group (0.096 ± 0.020, p<0.05). The platelet survival time was shortened in Vit. E deficient group of SHRSR; 3.0 days at 9-10 weeks. In Vit.E sufficient group of SHRSP. the platelet survival time was corrected to normal. The maximum uptake of 75SeM increased in both Vit.E deficient group of SHRSP (0.119 ± 0.010 vs 0.192 ± 0.030, p<0.01) and SHRSR (0.071 ± 0.016 vs 0.119 ± 0.018, p<0.01). The increased platelet production was not affected by blood pressure but it can be suppressed by treating with dipyridamole or giving Vit.E before 10 weeks of age.

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