Oral contraceptive and platelet lipid biosynthesis in female rats: Dose-response relationship

Lipids ◽  
1982 ◽  
Vol 17 (2) ◽  
pp. 111-114 ◽  
Author(s):  
M. Ciavatti ◽  
E. Davenas ◽  
G. Michel ◽  
S. Renaud
Keyword(s):  
Oral Contraceptive ◽  
Dose Response ◽  
Lipid Biosynthesis ◽  
Female Rats ◽  
Response Relationship ◽  
Dose Response Relationship

CAFFEINE-INDUCED ULCEROGENESIS IN THE RAT

1962 ◽  
Vol 40 (11) ◽  
pp. 1473-1476 ◽  
Author(s):  
C. J. Pfeiffer ◽  
G. H. Gass
Keyword(s):  
Dose Response ◽  
Statistical Evaluation ◽  
Female Rats ◽  
Gastric Ulcers ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Stomach Tube ◽  
Male And Female ◽  
Male And Female Rats ◽  
Ulcerogenic Effect

The present investigation has demonstrated that administration of caffeine alkaloid (6.25 mg/kg, 25 mg/kg, and 100 mg/kg) by stomach tube induces acute gastric ulcers in the fundus, pylorus, and antrum of fasting male and female rats. The ulcers are histologically characterized as superficial erosions of the glandular mucosa. Statistical evaluation of ulcer indices indicated a linear, log dose–response relationship for caffeine alkaloid, and a similar ulcerogenic effect in both male and female rats.

CAFFEINE-INDUCED ULCEROGENESIS IN THE RAT

1962 ◽  
Vol 40 (1) ◽  
pp. 1473-1476 ◽  
Author(s):  
C. J. Pfeiffer ◽  
G. H. Gass
Keyword(s):  
Dose Response ◽  
Statistical Evaluation ◽  
Female Rats ◽  
Gastric Ulcers ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Stomach Tube ◽  
Male And Female ◽  
Male And Female Rats ◽  
Ulcerogenic Effect

The present investigation has demonstrated that administration of caffeine alkaloid (6.25 mg/kg, 25 mg/kg, and 100 mg/kg) by stomach tube induces acute gastric ulcers in the fundus, pylorus, and antrum of fasting male and female rats. The ulcers are histologically characterized as superficial erosions of the glandular mucosa. Statistical evaluation of ulcer indices indicated a linear, log dose–response relationship for caffeine alkaloid, and a similar ulcerogenic effect in both male and female rats.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

Mathematical Interpretation of the Pharmacodynamics of Homoeopathic Medicines

2021 ◽  
Vol 34 (01) ◽  
pp. 003-016
Author(s):  
John Michel Warner
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Dose Response ◽  
Oral Route ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Force Line ◽  
Administration Routes ◽  
Medicinal Substances ◽  
Medicine Administration

AbstractAccording to Hahnemann, homoeopathic medicines must be great immune responses inducers. In crude states, these medicines pose severe threats to the immune system. So, the immune-system of an organism backfires against the molecules of the medicinal substances. The complex immune response mechanism activated by the medicinal molecules can handle any threats which are similar to the threats posed by the medicinal molecules. The intersectional operation of the two sets, medicine-induced immune responses and immune responses necessary to cure diseases, shows that any effective homoeopathic medicine, which is effective against any disease, can induce immune responses which are necessary to cure the specific disease. In this article, this mechanism has been exemplified by the action of Silicea in human body. Also, a neuroimmunological assessment of the route of medicine administration shows that the oral cavity and the nasal cavity are two administration-routes where the smallest doses (sometimes even few molecules) of a particular homoeopathic medicine induce the most effective and sufficient (in amount) purgatory immune responses. Administering the smallest unitary doses of Silicea in the oral route can make significant changes in the vital force line on the dose–response relationship graph. The dose–response relationship graph further implicates that the most effective dose of a medicine must be below the lethality threshold. If multiple doses of any medicine are administered at same intervals, the immune-system primarily engages with the medicinal molecules; but along the passage of time, the engagement line splits into two: one engages with the medicinal molecules and another engages with diseases. The immune system's engagement with the diseases increases along the passage of time, though the engagement with the medicinal molecules gradually falls with the administration of descending doses. Necessarily, I have shown through mathematical logic that the descending doses, though they seem to be funny, can effectively induce the most effective immune responses.

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