Occurrence of mixtures of geometrical isomers of conjugated octadecatrienoic acids in some seed oils: Analysis by open-tubular gas liquid chromatography and high performance liquid chromatography

Lipids ◽  
1981 ◽  
Vol 16 (7) ◽  
pp. 546-551 ◽  
Author(s):  
Toru Takagi ◽  
Yutaka Itabashi
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Gas Liquid Chromatography ◽  
Seed Oils ◽  
Geometrical Isomers

Measurement of carbamazepine and its epoxide metabolite by high-performance liquid chromatography, and a comparison of assay techniques for the analysis of carbamazepine.

1977 ◽  
Vol 23 (12) ◽  
pp. 2283-2287 ◽  
Author(s):  
G W Mihaly ◽  
J A Phillips ◽  
W J Louis ◽  
F J Vajda
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Plasma Concentrations ◽  
Correlation Coefficients ◽  
High Performance Liquid Chromatographic ◽  
Biologically Active ◽  
Gas Liquid Chromatography ◽  
Carbamazepine Therapy ◽  
Regression Slopes

Abstract We describe a modified high-performance liquid-chromatographic method for the simultaneous analysis of carbamazepine andits biologically active metabolite, carbamazepine-10, 11-epoxide. Concentrations of both these compounds in the plasma of 35 epileptic patients receiving chronic carbamazepine therapy are presented. Concentrations of carbamazepine in plasma were related to those of carbamazepine-10, 11-epoxide (r - 0.495, P less than 0.05). Total daily doses of carbamazepine were better correlated with plasma concentrations of carbamazepine-10, 11-epoxide (r = 0.714, P less than 0.001) than of carbamazepine (r = 0.269, P greater than 0.05). Close correlations were found between results of the three assay procedures we used to measure plasma carbamazepine concentrations: high-performance liquid chromatography, gas-liquid chromatography, and enzyme immunoassay. Correlation coefficients exceeded 0.97 and regression slopes were near unity, indicating that all three procedures were individually specific for the quantification of plasma carbamazepine.

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