Lipid peroxidation: A mechanism involved in acute ethanol toxicity as demonstrated by in vivo pentane production in the rat

Lipids ◽  
1978 ◽  
Vol 13 (4) ◽  
pp. 305-307 ◽  
Author(s):  
Richard E. Litov ◽  
Dennis H. Irving ◽  
Jeanne E. Downey ◽  
Al L. Tappel
Keyword(s):  
Lipid Peroxidation ◽  
Ethanol Toxicity ◽  
Acute Ethanol ◽  
Pentane Production

Antioxidative Effects of Tetramethylpyrazine on Acute Ethanol-Induced Lipid Peroxidation

2005 ◽  
Vol 33 (06) ◽  
pp. 981-988 ◽  
Author(s):  
Chi-Feng Liu ◽  
Chia-Hsien Lin ◽  
Chin-Fa Chen ◽  
Tian-Chyuan Huang ◽  
Song-Chow Lin
Keyword(s):  
Lipid Peroxidation ◽  
Malonic Dialdehyde ◽  
Protective Mechanism ◽  
Scavenging Activity ◽  
Antioxidative Effect ◽  
Heart Homogenate ◽  
Acute Ethanol ◽  
Antioxidative Effects ◽  
Free Radical Formation

Acute p.o. administration of 99.5% ethanol (0.1 ml) to fasted mice produced heart toxicity. Pretreatment with p.o. administration of tetramethylpyrazine (TMP) could prevent such toxicity effectively and dose-dependently. The maximal antioxidative effect against 99.5% ethanol-induced heart toxicity could be observed at 1 hour after TMP administration. In order to further investigate the heart protective mechanism of TMP, both lipid peroxidation level in vivo and superoxide scavenging activity were conducted. TMP exhibited a dose-dependently anti-lipid peroxidation effect in mice heart homogenate, and results indicated that 99.5% ethanol-induced intoxicated mice hearts have higher malonic dialdehyde (MDA) levels compared with those in TMP administrated mice hearts. These results suggest that the potentially heart protective mechanism of TMP could be contributed, at least in part, to its prominent anti-lipid peroxidation and anti-free radical formation effects, hence it could protect the heart from lipid peroxidation-induced heart toxicity.

scholarly journals In Vivo Lipid Peroxidation in Chickens as Measured by Pentane Production Rate

1989 ◽  
Vol 6 (3) ◽  
pp. 167-174 ◽  
Author(s):  
Herbert FUHRMANN ◽  
Hans-Peter SALLMANN ◽  
Sandor MOLNAR
Keyword(s):  
Lipid Peroxidation ◽  
Production Rate ◽  
Pentane Production

Effects of dietary antioxidants on in vivo lipid peroxidation in the rat as measured by pentane production

Lipids ◽  
1978 ◽  
Vol 13 (6) ◽  
pp. 403-407 ◽  
Author(s):  
Jeanne E. Downey ◽  
Dennis H. Irving ◽  
Al L. Tappel
Keyword(s):  
Lipid Peroxidation ◽  
Dietary Antioxidants ◽  
Pentane Production

Synthesis of Ventricular Mitochondrial Proteins In Vivo: Effect of Acute Ethanol Toxicity

1993 ◽  
Vol 17 (4) ◽  
pp. 894-899 ◽  
Author(s):  
Tahir Siddiq ◽  
Jonathan R. Salisbury ◽  
Peter J. Richardson ◽  
Victor R. Preedy
Keyword(s):  
Mitochondrial Proteins ◽  
Ethanol Toxicity ◽  
Acute Ethanol

In vivo lipid peroxidation and platelet activation in Helicobacter pylori infection

2001 ◽  
Vol 120 (5) ◽  
pp. A670-A670
Author(s):  
M NERI ◽  
G DAVI ◽  
D FESTI ◽  
F LATERZA ◽  
A FALCO ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Helicobacter Pylori ◽  
Platelet Activation ◽  
Helicobacter Pylori Infection

Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia

2018 ◽  
Vol 18 (4) ◽  
pp. 365-371 ◽  
Author(s):  
Denis V. Mishchenko ◽  
Margarita E. Neganova ◽  
Elena N. Klimanova ◽  
Tatyana E. Sashenkova ◽  
Sergey G. Klochkov ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Acute Toxicity ◽  
Histone Deacetylases ◽  
Hydroxamic Acids ◽  
Water Soluble ◽  
Male Rat ◽  
Hybrid Male ◽  
Cyclic Hydroxamic Acids

Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in carcinogenesis. Objective: The work was aimed to (i) determine the anti-tumor and chemosensitizing activity of the novel racemic spirocyclic hydroxamic acids using experimental drug sensitive leukemia P388 of mice, and (ii) determine the structure-activity relationships as metal chelating and HDAC inhibitory agents. Method: Outbreed male rat of 200-220 g weights were used in biochemical experiments. In vivo experiments were performed using the BDF1 hybrid male mice of 22-24 g weight. Lipid peroxidation, Fe (II) -chelating activity, HDAC fluorescent activity, anti-tumor and anti-metastatic activity, acute toxicity techniques were used in this study. Results: Chemosensitizing properties of water soluble cyclic hydroxamic acids (CHA) are evaluated using in vitro activities and in vivo methods and found significant results. These compounds possess iron (II) chelating properties, and slightly inhibit lipid peroxidation. CHA prepared from triacetonamine (1a-e) are more effective Fe (II) ions cheaters, as compared to CHA prepared from 1- methylpiperidone (2a-e). The histone deacetylase (HDAC) inhibitory activity, lipophilicity and acute toxicity were influenced by the length amino acids (size) (Glycine < Alanine < Valine < Leucine < Phenylalanine). All compounds bearing spiro-N-methylpiperidine ring (2a-e) are non-toxic up to 1250 mg/kg dose, while compounds bearing spiro-tetramethylpiperidine ring (1a-e) exhibit moderate toxicity which increases with increasing lipophility, but not excite at 400 mg/kg. Conclusion: It was shown that the use of combination of non-toxic doses of cisplatin (cPt) or cyclophosphamide with CHA in most cases result in the appearance of a considerable anti-tumor effect of cytostatics. The highest chemosensitizing activity with respect to leukemia Р388 is demonstrated by the CHA derivatives of Valine 1c or 2c.

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