Specific inhibition of hepatic fatty acid synthesis exerted by dietary linoleate and linolenate in essential fatty acid adequate rats

Lipids ◽  
1976 ◽  
Vol 11 (6) ◽  
pp. 485-490 ◽  
Author(s):  
S. D. Clarke ◽  
D. R. Romsos ◽  
G. A. Leveille
Keyword(s):  
Fatty Acid ◽  
Essential Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Specific Inhibition ◽  
Hepatic Fatty Acid ◽  
Dietary Linoleate

scholarly journals The role of dietary protein in hepatic lipogenesis in the young rat

1981 ◽  
Vol 45 (3) ◽  
pp. 529-538 ◽  
Author(s):  
G. R. Herzberg ◽  
Minda Rogerson
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Dietary Protein ◽  
Fatty Acid Synthetase ◽  
Acid Synthesis ◽  
Hepatic Lipogenesis ◽  
Hepatic Fatty Acid ◽  
Cleavage Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase

1. The effect of varying dietary levels of casein (40–140 g/kg) on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1.1.1.49; G6PD), malic enzyme (EC 1.1.1.40; ME), citrate cleavage enzyme (EC 4.1.3.8;CCE), acetyl CoA carboxylase (EC 6.4.1.2; AcCx), glucokinase (EC 2.7.1.2; GK), and pyruvate dehydrogenase (PDH) was examined in young, growing rats.2. The activities of AcCx, FAS, G6PD and in vivo fatty acid synthesis were generally found to increase with increased dietary protein.3. The levels of GK and PDH were not related to dietary protein.4. ME decreased with increasing dietary protein.5. The results demonstrate a dissociation between hepatic fatty acid synthesis and ME and suggest that when rats consume low-protein diets the NADPH needed for fatty acid synthesis is generated primarily by ME but that as the level of dietary protein is increased the contribution of ME is reduced while that of the phosphogluconate pathway becomes more important.

Acute stimulatory effect of insulin on hepatic fatty acid synthesis

1980 ◽  
Vol 5 (2) ◽  
pp. XII-XIII
Author(s):  
Anton C. Beynen ◽  
Willem J. Vaartjes ◽  
Math J.H. Geelen
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Hepatic Fatty Acid

scholarly journals Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults

Diabetes ◽  
2016 ◽  
Vol 65 (7) ◽  
pp. 1858-1867 ◽  
Author(s):  
Camilla Pramfalk ◽  
Michael Pavlides ◽  
Rajarshi Banerjee ◽  
Catriona A. McNeil ◽  
Stefan Neubauer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Plasma Insulin ◽  
Acid Synthesis ◽  
Fat Content ◽  
Healthy Adults ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Hepatic Fatty Acid ◽  
Fasting Plasma Insulin

Cis-2-octenoic acid administration and essential fatty acid synthesis

Lipids ◽  
1966 ◽  
Vol 1 (3) ◽  
pp. 233-234 ◽  
Author(s):  
Robert E. Anderson ◽  
Raymond Reiser
Keyword(s):  
Fatty Acid ◽  
Essential Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Acid Administration

Fatty Acid Synthesis by Rat Liver after Chronic Ethanol Feeding with a Low-Fat Diet

1994 ◽  
Vol 87 (4) ◽  
pp. 441-446 ◽  
Author(s):  
K. J. Simpson ◽  
S. Venkatesan ◽  
T. J. Peters
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Fatty Acid Synthase ◽  
Plasma Lipids ◽  
Fold Increase ◽  
Acid Synthesis ◽  
Low Fat ◽  
Hepatic Fatty Acid ◽  
Low Fat Diet

1. Chronic alcohol feeding with a low-fat diet (4.4% total calories) produced a two- to three-fold increase in hepatic triacylglycerol and esterified cholesterol compared with pair-fed low-fat diet controls. Plasma lipids were similar in both groups. 2. Hepatic fatty acid synthesis rates measured in vivo with 3H2O were significantly lower in the alcohol-fed animals than in controls. Activities of hepatic fatty acid synthase (EC 2.3.1.85) and acetyl-CoA carboxylase (EC 6.4.1.2) were reduced in the alcohol-fed rats. 3. These results indicate that enhanced hepatic fatty acid synthesis does not occur in rats fed alcohol and a low-fat diet for 4 weeks, and is thus not implicated in the pathogenesis of alcohol-induced fatty liver.

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